pharmgen
commented
6 years ago Latest GPML for pathwayPA165292163 is obsolete. Use this instead: PA165292163-new.gpml
Note that even the updated GPML has errors that must be fixed:
- 'DNA damage' [id:adf19]: Missing PharmGKB Accession ID.
- 'DNA damage' [id:adf19]: Cellular location is 'Intracellular' but it's in a Nucleus.
- 'DNA damage' [id:adf19]: BlackBox should be converted to Phenotype or Process.
- 'TP53' [id:b860b]: Cellular location is 'Intracellular' but it's in a Nucleus.
- 'cell death' [id:bf8c5]: Missing PharmGKB Accession ID.
- 'cell death' [id:bf8c5]: BlackBox should be converted to Phenotype or Process.
- 'ERCC2' [id:c6203]: Cellular location is 'Intracellular' but it's in a Nucleus.
- 'DNA repair' [id:cc1ff]: Missing PharmGKB Accession ID.
- 'DNA repair' [id:cc1ff]: Cellular location is 'Intracellular' but it's in a Nucleus.
- 'DNA repair' [id:cc1ff]: BlackBox should be converted to Phenotype or Process.
- 'MSH2' [id:ce33b]: Cellular location is 'Intracellular' but it's in a Nucleus.
- 'lipid peroxidation and membrane damage' [id:e132f]: Missing PharmGKB Accession ID.
- 'lipid peroxidation and membrane damage' [id:e132f]: BlackBox should be converted to Phenotype or Process.
- 'oxidative stress' [id:e7cfd]: Missing PharmGKB Accession ID.
- 'oxidative stress' [id:e7cfd]: BlackBox should be converted to Phenotype or Process.
- 'reactive oxygen species' [id:f17ee]: Missing PharmGKB Accession ID.
- 'MLH1' [id:a41b3]: Cellular location is 'Intracellular' but it's in a Nucleus.
- 'TOP2A' [id:b56ad]: Cellular location is 'Intracellular' but it's in a Nucleus.
- 'doxorubicin' [id:dc25f]: Cellular location is 'Intracellular' but it's in a Nucleus.
- Activation line [id:ba45b] (from 'reactive oxygen species' [id:f17ee] to 'lipid peroxidation and membrane damage' [id:e132f]): Missing evidence.
- 'proteasome' [id:d85ba]: Drawing only elements cannot be used as interaction target.
- Activation line [id:bff40] (from 'reactive oxygen species' [id:f17ee] to 'oxidative stress' [id:e7cfd]): Missing evidence.
- Activation line [id:c124a] (from 'oxidative stress' [id:e7cfd] to 'cell death' [id:bf8c5]): Missing evidence.
- Activation line [id:e2869] (from 'DNA damage' [id:adf19] to 'cell death' [id:bf8c5]): Missing evidence.
- Activation line [id:efc87] (from 'DNA damage' [id:adf19] to 'DNA repair' [id:cc1ff]): Missing evidence.
- Biochemical Reaction line [id:f528d] (from 'doxorubicin' [id:ded73] to 'PK pathway' [id:a958c]): Missing evidence.
- Degradation line [id:f5312] (from 'doxorubicin semiquinone' [id:f72ee] to 'reactive oxygen species' [id:f17ee]): Degradation interactions cannot end on anything.
- Degradation line [id:f5312] (from 'doxorubicin semiquinone' [id:f72ee] to 'reactive oxygen species' [id:f17ee]): Missing evidence.
- Degradation line [id:f6e8f] (from 'doxorubicin semiquinone' [id:f72ee] to 'doxorubicin' [id:ded73]): Degradation interactions cannot end on anything.
- Activation line [id:fa4ae] (from 'reactive oxygen species' [id:f17ee] to 'DNA damage' [id:adf19]): Missing evidence.
Latest GPML for pathwayPA165292163 is obsolete. Use this instead: PA165292163-new.gpml
Note that even the updated GPML has errors that must be fixed: