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PoonLab / covizu

Rapid analysis and visualization of coronavirus genome variation
https://filogeneti.ca/CoVizu/
MIT License
46 stars 20 forks source link

Poisson regression is not a good model for filtering variants anymore #394

Closed ArtPoon closed 2 years ago

ArtPoon commented 2 years ago

Genomic diversity has undergone bottlenecks, so much of the variation in divergence has been restarting from more recent common ancestors.

ArtPoon commented 2 years ago

This isn't really an issue in the sense that current variation is much narrower than expected under the Poisson model

ArtPoon commented 2 years ago

Also see #385