Open antgduarte opened 4 years ago
Project-Evidence
commented
4 years ago Thank you for your work. We have incorporated portions of this into Revision 2.
May you provide a source and archive link for "Second China-U.S. Workshop on the Challenges of Emerging Infections, Laboratory Safety and Global Health Security"?
antgduarte
commented
4 years ago Source: http://english.whiov.cas.cn/News/Int_Cooperation_News/201707/W020170718313905257748.pdf
Archive: https://archive.is/w1zyW
Enviado de um dispositivo móvel.
A sábado, 2/05/2020, 21:16, Project-Evidence notifications@github.com escreveu:
Thank you for your work. We have incorporated portions of this into Revision 2 http://project-evidence.github.io.
May you provide a source and archive link for "Second China-U.S. Workshop on the Challenges of Emerging Infections, Laboratory Safety and Global Health Security"?
— You are receiving this because you authored the thread. Reply to this email directly, view it on GitHub https://github.com/Project-Evidence/project-evidence.github.io/issues/21#issuecomment-623007675, or unsubscribe https://github.com/notifications/unsubscribe-auth/APJZJ2LI3AQ7MDEG6ALZJ63RPR5P7ANCNFSM4MO6R75A .
Abstract
Proposed addition
(1) the SARS-CoV-2 virus [or its ancestor] was present at a biolaboratory in Wuhan, China, and (2) the SARS-CoV-2 virus [or its ancestor] was introduced into the greater Wuhan population by an infected lab worker or animal
This is because the eventual lab spillover may have envolved a less pathogenic ancestor of SARS-CoV-2 that later (e.g. outside the lab, after some time of undetected human-to-human transmission) mutated into the current strain. This seems to be supported by this (pre-print) paper:
https://www.biorxiv.org/content/10.1101/2020.02.10.942748v2
Section 8.5
Proposed addition
Second China-U.S. Workshop on the Challenges of Emerging Infections, Laboratory Safety and Global Health Security May 17-19, 2017 Wuhan, China Meeting Report
W020170718313905257748.pdf
Quote from p. 11-12 of this report:
"Zhengli Shi (Principal Investigator, Wuhan Institute of Virology, CAS) spoke about the evolution and pathogenesis of bat SARS like coronavirus (SL CoV). Shi is working on corona virus and other emerging infections and said that bat SL CoV could be the next pandemic. He described the cases and countries involved in the 2003 SARs outbreak. For bat corona virus to cause the next SL CoV outbreak many factors will have to be involved. His research looks at the pathogenesis of SL CoV in transgenic mice. It replicates very well in mice and human tissue. The virus can easily enter human cells but in the animal model the virus has less pathogenesis; this is good news. His research shows that some bat SL CoVs have potential interspecies transmission to other animals and humans. An audience member asked if one could clear an infected bat of this virus? Zhengli said that he tried this with Nipah virus in bats and bats could produce antibodies, clear within seven days. In nature we found that bats produce antibodies to some viruses but not all. SL CoV can exist in bats for several months. An audience member said that you cannot be sure that this pathogen will cause human disease and that more data are needed. Right now infections are very mild and there is no clinical syndrome. Further studies are needed."
Section 8.6.3
Requested link
Tao P. Expert in Wuhan collected ten thousands animals: capture bats in mountain at night. Changjiang Times 2017.
Link for the article: https://wxn.qq.com/cmsid/2017050300394400