RGLab / MAST

Tools and methods for analysis of single cell assay data in R
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DEG counts are associated with the number of cells #188

Open ZunpengLiu opened 4 months ago

ZunpengLiu commented 4 months ago

Hi there,

Thank you so much for developing and maintaining this useful tools.

I've been using MAST for a while. I found the number of DEGs are highly associated with the number of cells for different cell types, and I have used the "total_counts" and "nFeaturess_RNA" as the covariates. Do you have any suggestions? Should I add "the number of cell for each cell type" as a covariates? Does that make sense?

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Thank you! Zunpeng