Closed MarkDWilliams closed 3 years ago
Thanks @MarkDWilliams , keep the issues coming! I’ve tagged our KG2 people to take a look at this. Most likely it’s a mis-synonymized node or the like.
it looks like the questionable edge may be between "NCBIGene:6611" and "UMLS:C0728977" in KG2.3.4:
match p=(n)-[:close_match]-(m) where n.id in ["UMLS:C1420262", "HGNC:11123", "UMLS:C0795864", "MEDDRA:10081680", "UMLS:C0037875", "MESH:D013097", "UMLS:C3661485", "MESH:D058496", "UMLS:C1866927", "NCIT:C75469", "OMIM:300105", "OMIM:182290", "SNOMED:401315004", "SNOMED:64142003", "ORPHANET:819", "ORPHANET:138543", "MONDO:0008434", "DOID:0060768", "PR:P52788", "PR:000015301", "UniProtKB:P52788", "ENSEMBL:ENSG00000102172", "CHEMBL.TARGET:CHEMBL4934", "NCBIGene:6611", "PathWhiz.ProteinComplex:7228", "PathWhiz.ProteinComplex:4235", "PathWhiz.ProteinComplex:337", "PathWhiz.ProteinComplex:9617", "PathWhiz.ProteinComplex:9011", "PathWhiz.ProteinComplex:10029", "PathWhiz.ProteinComplex:8353"] and m.id in ["UMLS:C0028833", "ATC:H01CB02", "DRUGBANK:DB00104", "LOINC:MTHU035158", "LOINC:LP97954-9", "UMLS:C0724649", "UMLS:C0728977", "MESH:D015282", "UMLS:C1170602", "UMLS:C1518540", "UMLS:C1518539", "UMLS:C1521974", "UMLS:C1709307", "NCIT:C53447", "NCIT:C711", "UMLS:C1328681", "UMLS:C1518541", "UMLS:C0338271", "NCIT:C2402", "NDDF:004012", "NDDF:002107", "PDQ:CDR0000038866", "UMLS:C1328682", "UMLS:C1328680", "PDQ:CDR0000042358", "RXNORM:221130", "RXNORM:7617", "SNOMED:109055007", "SNOMED:109053000", "VANDF:4019472", "VANDF:4019864", "CHEBI:7726", "CHEMBL.COMPOUND:CHEMBL262746", "CHEMBL.COMPOUND:CHEMBL1680", "CHEMBL.COMPOUND:CHEMBL1200480", "CHEMBL.COMPOUND:CHEMBL2105834", "CHEMBL.COMPOUND:CHEMBL3182554", "CHEMBL.COMPOUND:CHEMBL3350037", "CHEMBL.COMPOUND:CHEMBL3545066", "HMDB:HMDB0014262", "KEGG:C07306"] return p limit 10
although there also seems to be a synonymization issue for SPMSY (UniProtKB:P52788):
I'll write this mis-synonymization up in a separate issue! (#1250)
@MarkDWilliams thanks for reporting, please don't ever hesitate to "bother".
However, you should be aware that we have a systemic problem with certain concepts being merged with others that should not be. There is a plan for fixing this, but an exact timeline is not currently known. It affects a small percentage of nodes, but with so many nodes, it is a substantial number overall. Your exact issue will not be fixed super soon since a broader fix is underway, but it will be fixed in the not too distant feature. We will use this example to verify the fix and will let you know when it is working. Feel free to report more, or skip the reporting of more until the broader fix is in place and many such issues are resolved, as you wish.
This appears to be a SemMedDB triple. In KG2.5.1, the Cypher query
match (n {id: 'NCBIGene:6611'})<-[r]-(m {id: 'UMLS:C0728977'}) return r.provided_by, r.relation, r.publications_info, r.predicate;
returns
["SEMMEDDB:"] |
"OBO:xref" |
"{'PMID:8702767': {'publication date': '1996 Aug 23', 'sentence': 'Within this region, Phe294 has previously been predicted to be essential for the binding of octapeptides (Kaupmann, K., Bruns, C., Raulf, F., Weber, H., Mattes, H., and Lubbert, H. (1995) EMBO J. 14, 727-735) based on the observation that SSTR1 can bind the octapeptide SMS-201-995 with reasonable affinity after a Ser-to-Phe conversion in the analogous region of this receptor (SSTR1S305F).', 'subject score': 923, 'object score': 764}, 'PMID:8491320': {'publication date': '1993 Apr', 'sentence': 'Thus, CEA concentration reflected cell number in vitro and tumor size in vivo as a response to treatment with SMS 201.995.', 'subject score': 1000, 'object score': 1000}, 'PMID:8406151': {'publication date': '1993 Sep', 'sentence': 'In conclusion, SMS 201-995 prevents basal and meal stimulated increases in serum gastrin during omeprazole therapy.', 'subject score': 1000, 'object score': 888}, 'PMID:8769372': {'publication date': '1996 Aug', 'sentence': 'A single Ser305 to Phe mutation in TM VII increased the affinity of hsst1, for SMS 201-995 nearly 100-fold, and when Gln291 was also exchanged to Asn in TM VII of hsst1, almost full sst2-like binding of SMS 201-995 was obtained.', 'subject score': 1000, 'object score': 1000}, 'PMID:8528360': {'publication date': '1994 Aug', 'sentence': 'Seven patients with growth hormone (GH)-secreting pituitary adenoma were treated preoperatively with octreotide (Sandostatin or SMS 201-995; a somatostatin analogue), and were compared with 18 non-treated patients in their clinical courses and adenoma analyses.', 'subject score': 1000, 'object score': 888}, 'PMID:8500346': {'publication date': '1993', 'sentence': 'The effect of SMS 201-995 occurred 12 h after the peptide injection, while CMI and TRH suppressed the proliferation after 24 h.', 'subject score': 1000, 'object score': 1000}, 'PMID:9051332': {'publication date': '1997 Feb', 'sentence': 'SMS 201-995 significantly improves the pain of migraine attacks, 2 h after the beginning of treatment.', 'subject score': 1000, 'object score': 1000}, 'PMID:9180350': {'publication date': '1997', 'sentence': 'These data suggest that the decrease of the number of 125I-Tyr3-SMS receptors, would explain the decreased sensitivity of AC to SMS 201-995 in membranes from 5-HT-pretreated acini.', 'subject score': 1000, 'object score': 1000}, 'PMID:8383153': {'publication date': '1993 Jan', 'sentence': 'These data confirm the effectiveness of SMS 201-995 in the VIPoma syndrome and suggest that calcitonin may ameliorate symptomatology and reduce circulating VIP level in patients with VIPoma tumor.', 'subject score': 1000, 'object score': 1000}, 'PMID:8564264': {'publication date': '1995 Oct', 'sentence': 'SMS 201-995 injected into the lateral ventricle (i.c.v., 100, 200, or 300 ng), paraventricular nucleus (PVN) or lateral hypothalamus (LH) (7.5, 15, or 30 ng) dose-dependently inhibited pentagastrin-stimulated gastric acid secretion.', 'subject score': 1000, 'object score': 850}, 'PMID:8745343': {'publication date': '1995 Sep', 'sentence': 'In conclusion, the effect of SMS 201-995 on colon cancer cell growth can be enhanced by its combination with cytokines in SW620 but not in SW480 colon adenocarcinoma cells.', 'subject score': 1000, 'object score': 916}, 'PMID:9153246': {'publication date': '1997 May 23', 'sentence': 'A 30-min exposure of cells to either SRIF or the analog SMS 201-995 (SMS) reduced both the potency and efficacy of agonist inhibition of adenylyl cyclase.', 'subject score': 916, 'object score': 888}, 'PMID:9408049': {'publication date': '1997', 'sentence': 'Fourteen hours after PBDL, the SS receptors, the capacity of the SS analogue SMS 201-995 to inhibit forskolin-stimulated adenylate cyclase activity and PTX-catalyzed [32P] ADP-ribosylation of the alpha1 subunits of Gi proteins could not be detected in pancreatic acinar membranes.', 'subject score': 893, 'object score': 850}, 'PMID:8511502': {'publication date': '1993 May', 'sentence': 'The effect of a somatostatin analogue, SMS 201-995 (SMS), on antral gastrin cell hyperplasia (AGH) and hypergastrinemia associated with 14-day administration of the histamine H2-receptor antagonist (H2-RA) famotidine was studied in rats.', 'subject score': 1000, 'object score': 1000}, 'PMID:8725462': {'publication date': '1996', 'sentence': 'Successful control of external biliary fistula by using SMS 201-995 in a child.', 'subject score': 1000, 'object score': 1000}, 'PMID:8754775': {'publication date': '1996 Aug', 'sentence': 'Octapeptide somatostatin analog SMS 201-995 induces translocation of intracellular PTP1C to membranes in MCF-7 human breast adenocarcinoma cells.', 'subject score': 858, 'object score': 840}, 'PMID:9221906': {'publication date': '1997 Jul', 'sentence': 'SKF 38393 as well as bromocriptine increased the capacity of SMS 201-995 to accumulate IP3 in the rat striatum although this effect was only statistically significant in the case of SKF 38393.', 'subject score': 888, 'object score': 1000}, 'PMID:9222554': {'publication date': '1997 Jul', 'sentence': '[125I]-[LTT]SRIF-28 and [125I]-SMS 201-995 were used to identify and characterize somatostatin (SRIF) receptors localized in rat lung tissue.', 'subject score': 1000, 'object score': 1000}, 'PMID:8486215': {'publication date': '1993 Apr', 'sentence': 'We conclude that SMS 201-995 is useful for the treatment of portal hypertension because of its effect of reducing portal pressure with mild changes in systemic hemodynamics.', 'subject score': 1000, 'object score': 1000}, 'PMID:9103503': {'publication date': '1997 Apr', 'sentence': 'SMS-201-995 (10 nmol/kg/hr) inhibited acid secretion similarly to somatostatin-14, indicating that activation of sst2, sst3 and/or sst5 receptors accounts for acid inhibition induced by somatostatin.', 'subject score': 1000, 'object score': 1000}, 'PMID:9196070': {'publication date': '1997 Jun 09', 'sentence': 'Since, SMS 201-995 was reported to bind with high affinity only to somatostatin receptors type 2, 3 and 5, the lack of effect of this compound on interleukin 6 release suggests that the inhibitory action of somatostatin could be mediated by the activation of either type 1 or type 4 somatostatin receptors.', 'subject score': 1000, 'object score': 991}, 'PMID:2904131': {'publication date': '1988 Dec', 'sentence': 'Chronic infusions of SMS 201-995 produced marked neurotoxic effects characterized by truncal ataxia, dysmetria, and severe bradykinesia, with normal level of consciousness.', 'subject score': 1000, 'object score': 890}, 'PMID:2844221': {'publication date': '1988 Jul', 'sentence': 'Evaluation of the synthetic somatostatin analogue SMS 201-995 in patients with hypoglycaemia associated with hepatocellular carcinoma.', 'subject score': 840, 'object score': 1000}, 'PMID:2454125': {'publication date': '1988 Apr', 'sentence': 'Similarly, the previously reported increase in glucose-6-phosphate dehydrogenase (EC 1.1.1.49) and 6-phosphogluconate dehydrogenase (EC 1.1.1.44) found in the kidney at 2 and 7 days of diabetes was less marked in the group receiving SMS 201-995.', 'subject score': 1000, 'object score': 868}, 'PMID:2844445': {'publication date': '1988 Feb', 'sentence': "This is the first report of the successful use of SMS 201-995 in carcinoid-induced Cushing's syndrome, and suggests that this hormone analogue could be valuable in the long term medical management of such patients.", 'subject score': 1000, 'object score': 824}, 'PMID:2394336': {'publication date': '1990 Oct', 'sentence': "These results indicate that the patient's acute secretory diarrhea, occurring after large intestinal obstruction, originated in the small intestine and that SMS 201-995 can be used to manage this unusual severe postoperative problem.", 'subject score': 1000, 'object score': 813}, 'PMID:2334410': {'publication date': '1990 Apr 30', 'sentence': 'GH-releasing hormone and a somatostatin analogue, SMS 201-995, did not affect GH secretion from non-stimulated and PHA-stimulated PBMCs.', 'subject score': 1000, 'object score': 1000}, 'PMID:1854508': {'publication date': '1991', 'sentence': 'The somatostatin analogue SMS 201-995 has a beneficial effect in the treatment of patients with the carcinoid syndrome.', 'subject score': 893, 'object score': 1000}, 'PMID:2724869': {'publication date': '1989 Apr 17', 'sentence': 'After failure of several attempts of symptomatic, antibiotic, and antiviral therapy, the long-acting somatostatin analogue SMS 201-995 was administered to the patients subcutaneously in a dose between 2 x 50 micrograms and 3 x 100 micrograms/day.', 'subject score': 841, 'object score': 861}, 'PMID:2844705': {'publication date': '1988 Aug', 'sentence': 'It is concluded that SMS 201-995 can be effective in reducing secretory diarrhea in infants.', 'subject score': 1000, 'object score': 884}, 'PMID:1974801': {'publication date': '1990', 'sentence': 'Speculation on the role of the tails in species-specific recognition is supported by the nature of amino acid residue substitutions in urotensin II, somatostatin, and SMS 201-995 and suggests the existence of multiple receptor types for this group of peptides.', 'subject score': 892, 'object score': 1000}, 'PMID:2875321': {'publication date': '1986 Sep 13', 'sentence': 'Treatment of autonomic neuropathy with a somatostatin analogue SMS-201-995.', 'subject score': 893, 'object score': 1000}, 'PMID:2875493': {'publication date': '1986 Jul', 'sentence': 'Therefore, the rat brain, in particular the cortex, possesses a SMS 201-995-sensitive, Mg2+-dependent SS receptor subpopulation (SS1) as well as a SMS 201-995-insensitive, Mg2+-independent SS population (SS2).', 'subject score': 589, 'object score': 589}, 'PMID:1704631': {'publication date': '1991 Jan', 'sentence': 'Intravenous administration of SMS 201-995 in the three different doses described above caused dose-dependent suppression of the increase in pancreatic exocrine secretion as well as the plasma concentration of secretin and CCK induced by intraduodenal infusion of oleic acid.', 'subject score': 1000, 'object score': 1000}, 'PMID:2875590': {'publication date': '1986', 'sentence': 'In addition the potential role of therapy with Somatostatin analogs and the preliminary effects of Somatostatin and/or SMS 201-995 are discussed in disorders of gastro-intestinal function (haemorrhages, diarrhoea, pancreatitis and endocrine pancreatic tumours), diabetes mellitus, central nervous system disturbances and oncology.', 'subject score': 1000, 'object score': 1000}, 'PMID:2575406': {'publication date': '1989 Dec', 'sentence': 'We conclude that combined SMS 201-995 and bromocriptine therapy is safe and frequently suppresses GH and PRL secretion.', 'subject score': 916, 'object score': 1000}, 'PMID:2215839': {'publication date': '1990 Aug', 'sentence': 'Treatment of hypertension, small carbohydrate meals, caffeine and treatment with the somatostatin analogue SMS 201-995 may have a beneficial effect.', 'subject score': 1000, 'object score': 893}, 'PMID:3236932': {'publication date': '1988 Dec 10', 'sentence': '[Treatment of pancreatic apudomas with a somatostatin analog SMS 201-995].', 'subject score': 893, 'object score': 888}, 'PMID:2276223': {'publication date': '1990 Oct', 'sentence': 'These results demonstrate that growth hormone was only partially suppressed by SMS 201-995 in insulin-dependent diabetic subjects.', 'subject score': 1000, 'object score': 1000}, 'PMID:2666249': {'publication date': '1989 Sep', 'sentence': 'A retrospective subgroup analysis according to age, sex, localization of the ulcers, severity of the bleeding, and arterial spurting vs. oozing showed homogeneity and did not allow identification of a subgroup that might benefit from treatment with SMS 201-995.', 'subject score': 1000, 'object score': 1000}, 'PMID:2876005': {'publication date': '1986 Nov', 'sentence': 'Somatostatin analog SMS 201-995 and insulin needs in insulin-dependent diabetic patients studied by means of an artificial pancreas.', 'subject score': 893, 'object score': 916}, 'PMID:2185966': {'publication date': '1990', 'sentence': 'Long-term treatment with the somatostatin analogue SMS 201-995: alternative to pancreatectomy in persistent hyperinsulinaemic hypoglycaemia of infancy.', 'subject score': 1000, 'object score': 893}, 'PMID:2186055': {'publication date': '1990 May', 'sentence': 'Gastrointestinal glucose absorption was delayed, and insulin secretion suppressed during treatment with SMS 201-995.', 'subject score': 1000, 'object score': 1000}, 'PMID:2876235': {'publication date': '1986 Oct 04', 'sentence': 'Oral administration of the long-acting somatostatin analogue, SMS 201-995 (Sandoz), was assessed in five patients with active acromegaly, four of whom had not responded to pituitary irradiation.', 'subject score': 1000, 'object score': 888}, 'PMID:3146715': {'publication date': '1988', 'sentence': 'The effects of SMS 201-995 might be attributed to an improvement of renal haemodynamics through inhibition of vasoconstrictor systems acting in cirrhosis.', 'subject score': 1000, 'object score': 1000}, 'PMID:2876493': {'publication date': '1986', 'sentence': 'A pilot study of SMS 201-995 in the treatment of severe acute upper GI bleeding resulted in cessation of bleeding, with no rebleeding during or within 24 h after the trial in 8 of 10 patients.', 'subject score': 1000, 'object score': 928}, 'PMID:2876495': {'publication date': '1986', 'sentence': 'SMS 201-995 is therefore a useful therapeutic tool in the long-term management of patients with symptoms due to uncontrolled hormone secretion from neuroendocrine tumours.', 'subject score': 1000, 'object score': 1000}, 'PMID:2876498': {'publication date': '1986', 'sentence': 'Acute and long-term effects of SMS 201-995 in acromegaly.', 'subject score': 1000, 'object score': 1000}, 'PMID:2876499': {'publication date': '1986', 'sentence': 'The efficacy and safety of chronically administered SMS 201-995 in active acromegaly opens new horizons for its treatment.', 'subject score': 884, 'object score': 888}, 'PMID:2876501': {'publication date': '1986', 'sentence': 'SMS 201-995 inhibits secretion of insulin, glucagon, and TSH in addition to growth hormone and induces carbohydrate intolerance when administered before food in normal subjects.', 'subject score': 1000, 'object score': 1000}, 'PMID:2876502': {'publication date': '1986', 'sentence': 'We conclude that SMS 201-995 could be an excellent tool for further clinical investigation and therapy of diabetic vascular complications.', 'subject score': 1000, 'object score': 1000}, 'PMID:2876507': {'publication date': '1986', 'sentence': 'Starting from a hypothetical conformation of natural somatostatin and a knowledge of the minimal fragment needed for biological activity, a process of rational design and lead optimization has led to the potent, selective, and long-acting analogue SMS 201-995, (formula: see text) which selectively inhibits growth hormone secretion in several animal species for up to 6 h after subcutaneous application.', 'subject score': 846, 'object score': 1000}, 'PMID:2876509': {'publication date': '1986', 'sentence': 'Postprandial effects of SMS 201-995 on gut hormones and glucose tolerance.', 'subject score': 1000, 'object score': 983}, 'PMID:2876510': {'publication date': '1986', 'sentence': 'The effect of SMS 201-995, a long-acting somatostatin analogue, on anterior pituitary function in healthy male volunteers.', 'subject score': 852, 'object score': 1000}, 'PMID:2876511': {'publication date': '1986', 'sentence': 'The results can be summarized as follows: SMS 201-995 is a potent inhibitor of gastric acid secretion, exerting near maximal inhibition at a dose of greater than or equal to 0.56 micrograms kg-1 h-1.', 'subject score': 1000, 'object score': 1000}, 'PMID:2876570': {'publication date': '1986 Sep', 'sentence': 'Moreover, treatment with SMS 201-995 was associated with a substantial reduction in pituitary enlargement and an improvement in her gastric symptoms.', 'subject score': 1000, 'object score': 1000}, 'PMID:1705618': {'publication date': '1991 Mar', 'sentence': 'To test this hypothesis, 2 mm methylcellulose disks containing concentrations of SMS 201-995 and RC-160 at 0, 0.5, 2.5, or 50 micrograms per disk, were implanted on the chorioallantoic membrane (CAM) of 6- to 7-day-old shell-less chick embryos.', 'subject score': 1000, 'object score': 1000}, 'PMID:2757427': {'publication date': '1989 Aug', 'sentence': 'Long-acting analogue of somatostatin--SMS 201-995--is highly effective in the prevention of clinical symptoms related to the dumping syndrome.', 'subject score': 1000, 'object score': 888}, 'PMID:2306870': {'publication date': '1990', 'sentence': 'Double-blind placebo-controlled trials are currently in progress to confirm the efficacy of SMS 201-995 in psoriasis.', 'subject score': 1000, 'object score': 1000}, 'PMID:2155884': {'publication date': '1990 Jan', 'sentence': 'The newly developed long-acting somatostatin analogue SMS 201-995 was used to treat a patient with the presumptive diagnosis of benign insulinoma.', 'subject score': 841, 'object score': 1000}, 'PMID:2817765': {'publication date': '1989', 'sentence': 'We studied for over 7 months the use of SMS 201-995, in 1 woman with pituitary adenoma.', 'subject score': 1000, 'object score': 861}, 'PMID:1315610': {'publication date': '1992 Jan', 'sentence': 'The treatment with SMS 201-995 directly evoked a reduction of serum GH in acromegalic patients and at the same time, the levels of serum SMC and 1,25-(OH)2D3 were decreased.', 'subject score': 1000, 'object score': 1000}, 'PMID:1947381': {'publication date': '1991 Jul', 'sentence': 'The results of two acute treatment tests using SMS 201-995 (SMS), over a 24 hour period in acromegalic patients are presented.', 'subject score': 1000, 'object score': 861}, 'PMID:2817814': {'publication date': '1989 Jul-Aug', 'sentence': 'To investigate the feasibility of a novel form of endocrine therapy that would exploit such dependence, we treated 8 patients with non-endocrine solid tumours with the somatostatin analogue SMS 201-995, in an effort to reduce growth hormone-stimulated IGF-I production.', 'subject score': 893, 'object score': 786}, 'PMID:2576751': {'publication date': '1989 Dec', 'sentence': 'In contrast, a somatostatin analog, SMS 201-995, revealed the inhibitory effects on the basal- and GRF-induced secretion of 7B2 at the concentration of 10(-7) M.', 'subject score': 1000, 'object score': 1000}, 'PMID:3297965': {'publication date': '1987', 'sentence': 'The long-acting somatostatin analogue SMS 201-995 has given promising results in 2 patients.', 'subject score': 841, 'object score': 861}, 'PMID:2877536': {'publication date': '1986', 'sentence': 'Normalization of glucose homeostasis by a long-acting somatostatin analog SMS 201-995 in a newborn with nesidioblastosis.', 'subject score': 841, 'object score': 1000}, 'PMID:2576951': {'publication date': '1989', 'sentence': 'Use of somatostatin analog SMS 201-995 in medullary thyroid carcinoma.', 'subject score': 893, 'object score': 913}, 'PMID:2846625': {'publication date': '1988 Nov', 'sentence': 'We conclude that SMS 201-995 can reduce ACTH as well as gastrin secretion from islet cell carcinomas as well as control tumor growth.', 'subject score': 1000, 'object score': 1000}, 'PMID:2877605': {'publication date': '1986 Dec', 'sentence': 'Plasma immunoreactive levels of SMS 201-995 related inversely to growth hormone concentration: A reproducible threshold for growth hormone inhibition in five of the patients, ranging from 70 to 1200 pg/mL, was maintained for 6 to 8 hours after the injections.', 'subject score': 1000, 'object score': 734}, 'PMID:3058374': {'publication date': '1988 Oct', 'sentence': 'After SMS 201-995, an enhancement of the increase in blood glucose (8.2 +/- 0.7 vs 4.7 +/- 0.2 mmol/l, P less than 0.01) and inhibition and postponement of the postprandial rise in insulin (27.6 +/- 6.7 vs 9.9 +/- 2.1 m-units/l, P less than 0.05) occurred.', 'subject score': 1000, 'object score': 1000}, 'PMID:2426819': {'publication date': '1986 Aug', 'sentence': 'SMS 201-995 blocks acid secretion and secretin- and calcium-stimulated gastrin release, indicating that SMS 201-995 inhibits peptide secretion by postreceptor mechanisms.', 'subject score': 1000, 'object score': 1000}, 'PMID:1467319': {'publication date': '1992', 'sentence': 'A comparison of SMS 201-995 and oesophageal tamponade in the control of acute variceal haemorrhage.', 'subject score': 1000, 'object score': 901}, 'PMID:1347515': {'publication date': '1992 Mar 12', 'sentence': 'The somatostatin analog SMS 201-995 (SMS) decreased the growth-promoting effect of bFGF.', 'subject score': 893, 'object score': 1000}, 'PMID:2668129': {'publication date': '1989 Jul', 'sentence': 'The effect of a long acting somatostatin analogue SMS 201-995 on stomal effluents in patients with severe short bowel syndrome was investigated in a double blind placebo controlled balance study.', 'subject score': 841, 'object score': 1000}, 'PMID:2878008': {'publication date': '1986 Dec', 'sentence': 'Since in acromegaly there is increased collagen production, we measured serum PIIIP in acromegalic patients before any treatment (basal), during medical treatment with the somatostatin analog SMS 201-995, and after pituitary adenomectomy.', 'subject score': 893, 'object score': 861}, 'PMID:2878009': {'publication date': '1987 Jan', 'sentence': 'The response of serum growth hormone levels to the long-acting somatostatin analog SMS 201-995 in acromegaly.', 'subject score': 841, 'object score': 1000}, 'PMID:2038180': {'publication date': '1991 May', 'sentence': 'SMS 201-995 inhibited CCK-8-induced, but not meal-induced, ileal luminal PYY recovery.', 'subject score': 1000, 'object score': 740}, 'PMID:2668325': {'publication date': '1989 Sep', 'sentence': 'Increasing the frequency of delivery of SMS 201-995 may be an alternative to increasing the dose in some patients with acromegaly.', 'subject score': 1000, 'object score': 1000}, 'PMID:2878747': {'publication date': '1986 Jun', 'sentence': 'SMS 201-995, 50 micrograms, given twice daily shortly before meals does not suppress 24 h GH secretion, but demonstrates significant effects on metabolism and causes side effects in normal subjects.', 'subject score': 1000, 'object score': 1000}, 'PMID:2878748': {'publication date': '1986 Aug', 'sentence': 'It is concluded that SMS 201-995 does not affect tumorous PRL secretion in patients with pure prolactinomas.', 'subject score': 1000, 'object score': 828}, 'PMID:2878866': {'publication date': '1986 Nov', 'sentence': 'The beneficial effects of long acting somatostatin analogue SMS 201-995 in an acromegalic patient affected by severe diabetes mellitus are reported.', 'subject score': 841, 'object score': 861}, 'PMID:2518866': {'publication date': '1989 Dec', 'sentence': 'These results indicate prolonged and potent effects of single subcutaneous doses of SMS 201-995 on peptone-meal stimulated acid secretion and gastrin release.', 'subject score': 1000, 'object score': 1000}, 'PMID:3059976': {'publication date': '1988', 'sentence': 'SMS 201-995 was administered to 40 acromegalic patients, in a multicentric study.', 'subject score': 1000, 'object score': 802}, 'PMID:2279532': {'publication date': '1990 Sep', 'sentence': 'The present study evaluated the effects of a long acting SRIF analogue, SMS 201-995 on the progression of renal failure in 3/4 nephrectomized (NPX) rats.', 'subject score': 1000, 'object score': 825}, 'PMID:2759484': {'publication date': '1989 Jul', 'sentence': 'Subsequent administration of SMS 201-995 for a nine month period was not associated with adverse side effects or an impairment of growth velocity.', 'subject score': 1000, 'object score': 901}, 'PMID:1499547': {'publication date': '1992 Aug 01', 'sentence': 'Incubation of pancreatic acini with somatostatin analogues, SMS 201-995 or BIM 23014, resulted in a stimulation of membrane PTPase activity.', 'subject score': 1000, 'object score': 1000}, 'PMID:2879447': {'publication date': '1986 Dec 22', 'sentence': 'In a patient with diabetic diarrhea unresponsive to all treatments, SMS 201-995 therapy controlled the diarrhea but did not interfere with control of the diabetes.', 'subject score': 916, 'object score': 1000}, 'PMID:2879448': {'publication date': '1986 Dec 22', 'sentence': 'In vitro, SMS 201-995 inhibits basal gastrin secretion from gastrinoma prepared in acute cell dispersion, but not gastrinoma in cell culture, probably due to differences in basal secretory rates.', 'subject score': 893, 'object score': 851}, 'PMID:2879449': {'publication date': '1986 Dec 22', 'sentence': 'In the presence of 10 mM arginine plus glucose at a concentration of either 8.8 or 17.6 mM, insulin secretion was reduced by both SMS 201-995 and somatostatin-14 to levels obtained with glucose alone.', 'subject score': 1000, 'object score': 771}, 'PMID:2879451': {'publication date': '1986 Dec 22', 'sentence': 'Compound SMS 201-995 provided safe and effective therapy for postprandial hypotension.', 'subject score': 649, 'object score': 861}, 'PMID:2879452': {'publication date': '1986 Dec 22', 'sentence': 'Effects of SMS 201-995 on intermediary metabolism and endocrine status in normal and diabetic humans.', 'subject score': 1000, 'object score': 1000}, 'PMID:2879453': {'publication date': '1986 Dec 22', 'sentence': 'Overall, SMS 201-995 appears to be a valuable new agent for the treatment of acromegaly, but long-term safety needs to be established.', 'subject score': 1000, 'object score': 1000}, 'PMID:1678601': {'publication date': '1991 Aug 15', 'sentence': 'The effects of somatostatin-14 and its biologically active analogs, RC-160 and SMS 201-995, on (Ca,Mg)ATPase activity in vitro were studied in homogenates of anterior pituitary cells.', 'subject score': 1000, 'object score': 1000}, 'PMID:1978946': {'publication date': '1990 Dec', 'sentence': 'We examined the ability of the somatostatin analogue, SMS 201-995, to inhibit 5-HT release in vitro.', 'subject score': 1000, 'object score': 1000}, 'PMID:1859412': {'publication date': '1991 Jul 31', 'sentence': 'It was shown that not only in vivo injections of SMS 201-995, but also, unexpectedly, in vitro incubation with bombesin inhibited [3H]-thymidine incorporation.', 'subject score': 1000, 'object score': 1000}, 'PMID:2760170': {'publication date': '1989 Sep', 'sentence': 'The effects on gallbladder motility of long term treatment with the somatostatin analog SMS 201-995 (SMS) were studied in five patients with acromegaly treated for 6-32 months with 200-300 micrograms SMS daily.', 'subject score': 893, 'object score': 888}, 'PMID:2069853': {'publication date': '1991 Jun', 'sentence': 'In two of these four patients, serum CEA levels fell modestly during SMS 201.995 therapy.', 'subject score': 916, 'object score': 888}, 'PMID:1440173': {'publication date': '1992 Nov', 'sentence': 'Pentagastrin administration increased the three parameters of tumoral growth by 40 percent and reduced survival time to 29.6 days (p < 0.01), while SMS 201-995 inhibited growth by 40 percent and prolonged survival time to 48.5 days (p < 0.01).', 'subject score': 1000, 'object score': 1000}, 'PMID:2642488': {'publication date': '1989 Jan', 'sentence': 'These results suggest that SMS 201-995 may be administered to patients with insulin-dependent diabetes mellitus without a deleterious effect on metabolic control.', 'subject score': 1000, 'object score': 1000}, 'PMID:2702445': {'publication date': '1989 Feb', 'sentence': 'The packed cell volume, pulse and systolic blood pressure changes of early dumping were significantly reduced by SMS 201-995 and the fall in blood glucose in patients with late dumping was abolished.', 'subject score': 1000, 'object score': 1000}, 'PMID:1410521': {'publication date': '1992 Jun', 'sentence': 'It appears that the somatostatin analogue SMS-201-995 has a marked stimulatory effect on the in vivo prostanoid production by the villous adenoma.', 'subject score': 893, 'object score': 850}, 'PMID:1679709': {'publication date': '1991 May', 'sentence': 'Cyclic AMP responses to stimulatory ligands vasoactive intestinal peptide (VIP), isoproterenol, and forskolin and inhibitory agonists neuropeptide Y (NPY), the synthetic somatostatin analogue SMS 201-995, and alpha-adrenergic agents were investigated in tissues from normal eyes and compared to the same responses in tissues from sympathetically denervated eyes.', 'subject score': 1000, 'object score': 840}, 'PMID:2880861': {'publication date': '1987 Mar', 'sentence': 'Medical treatment of acromegaly with SMS 201-995, a somatostatin analog: a comparison with bromocriptine.', 'subject score': 1000, 'object score': 1000}, 'PMID:2702888': {'publication date': '1989 Apr', 'sentence': 'In contrast, in vivo loop studies demonstrated that systemic administration of SMS 201-995 for five consecutive days produced a paradoxical decrease in basal colonic fluid absorption with no effect in jejunum or ileum.', 'subject score': 1000, 'object score': 1000}, 'PMID:2548911': {'publication date': '1989', 'sentence': 'The results of SMS 201-995 in the treatment of glucagonoma syndrome are reviewed.', 'subject score': 1000, 'object score': 1000}, 'PMID:1980282': {'publication date': '1990 Sep', 'sentence': 'The inhibitory effect SMS 201-995 exerted on cell proliferation was associated with a dose- and time-related reduction in both c-myc and c-fos mRNA levels.', 'subject score': 861, 'object score': 861}, 'PMID:2881419': {'publication date': '1987 Feb', 'sentence': 'The patients received daily 3 X 100 micrograms of SMS 201-995 subcutaneously.', 'subject score': 923, 'object score': 1000}, 'PMID:2881511': {'publication date': '1986', 'sentence': 'The Somatostatin analogue SMS 201-995 induces a long-lasting inhibition of GH secretion and may be useful in the treatment of acromegalic patients.', 'subject score': 893, 'object score': 861}, 'PMID:1378566': {'publication date': '1992 Apr', 'sentence': 'SMS 201-995 has a longterm tumor shrinkage effect and improves endocrinopathies.', 'subject score': 1000, 'object score': 966}, 'PMID:2491862': {'publication date': '1989 Jan', 'sentence': 'On the contrary, the inhibitory effects of SMS 201-995 on TSH secretion in patients with nnIST are weaker and transient.', 'subject score': 1000, 'object score': 1000}, 'PMID:3155299': {'publication date': '1988 Jul', 'sentence': 'GH secretory dynamics and responsiveness to SMS 201-995 treatment in acromegaly.', 'subject score': 916, 'object score': 1000}, 'PMID:3155325': {'publication date': '1987 Jul', 'sentence': 'The effect of long acting somatostatin analogue SMS 201-995 in acromegaly.', 'subject score': 841, 'object score': 1000}, 'PMID:2882047': {'publication date': '1986', 'sentence': 'The effects of somatostatin and SMS 201-995 on experimentally-induced pancreatitis and endotoxaemia in rats and on monocyte activity in patients with cirrhosis and portal hypertension.', 'subject score': 1000, 'object score': 1000}, 'PMID:2882057': {'publication date': '1986', 'sentence': 'Our results showed a dose-dependent effect of SMS 201-995 on the mortality, incidence, and intensity of cysteamine-induced duodenal lesions in rats.', 'subject score': 1000, 'object score': 1000}, 'PMID:2131392': {'publication date': '1990 Dec 08', 'sentence': '[The usefulness of the somatostatin analog SMS 201-995 in treating Cryptosporidium-induced diarrhea associated with the acquired immunodeficiency syndrome].', 'subject score': 893, 'object score': 1000}, 'PMID:1741824': {'publication date': '1991 Sep', 'sentence': 'Treatment of intestinal cryptosporidiosis with zidovudine and SMS 201-995, a somatostatin analog.', 'subject score': 1000, 'object score': 1000}, 'PMID:3065005': {'publication date': '1988 Sep', 'sentence': 'Ineffectiveness of SMS 201-995 in severe hyperinsulinemia.', 'subject score': 1000, 'object score': 888}, 'PMID:1351720': {'publication date': '1992 Jun 15', 'sentence': 'Unsuccessful treatment of certain types of carcinoid tumor with SMS 201-995 may be partly due to the direct growth-stimulatory effect of SMS 201-995 on carcinoid cells.', 'subject score': 1000, 'object score': 1000}, 'PMID:3065203': {'publication date': '1988 Dec', 'sentence': 'We report on a case of severe hypoglycemia observed after injection of the somatostatin analog SMS 201-995 in an insulin-dependent diabetic patient connected to an artificial pancreas (Biostator GCIIS).', 'subject score': 893, 'object score': 916}, 'PMID:2883024': {'publication date': '1987 Apr 15', 'sentence': 'Inhibition by SMS 201-995 of normal mammary gland growth in mice.', 'subject score': 1000, 'object score': 888}, 'PMID:2883059': {'publication date': '1987', 'sentence': 'The effect on gut motility of a single subcutaneous injection of 50 micrograms of the long-acting somatostatin analogue, SMS 201-995, was investigated in 8 normal volunteers who took a drink containing 99mTc and lactulose with a mixed meal.', 'subject score': 1000, 'object score': 790}, 'PMID:2883060': {'publication date': '1987', 'sentence': 'Compared with placebo, SMS 201-995 significantly diminished pancreatic amylase, trypsin and lipase output after stimulation with CCK, while the secretion of fluid and bicarbonate in response to secretin was unchanged.', 'subject score': 1000, 'object score': 1000}, 'PMID:1709749': {'publication date': '1991 Feb 01', 'sentence': 'This work investigates the effects of the long-acting somatostatin analogue, octreotide also named SMS 201-995 or Sandostatin, on pancreatic growth in function of the dose and duration of treatment.', 'subject score': 810, 'object score': 888}, 'PMID:1352086': {'publication date': '1992 Jun', 'sentence': 'Incubation of the cells with the stable somatostatin analogue SMS 201-995 (SMS) resulted in a rapid and transient activation of crude membrane PTPase activity.', 'subject score': 840, 'object score': 1000}, 'PMID:2043408': {'publication date': '1991 Mar', 'sentence': '[A favorable response to the somatostatin analog SMS 201-995 in a patient with the carcinoid syndrome].', 'subject score': 893, 'object score': 1000}, 'PMID:2883149': {'publication date': '1987 Jan', 'sentence': 'The conformational properties of two of them, showing intermediate activities between those of SMS 201-995 and somatostatin, have been studied by high field n.m.r. spectroscopy in DMSO.', 'subject score': 1000, 'object score': 1000}, 'PMID:2581647': {'publication date': '1985 May', 'sentence': 'These results suggest that SRIF and SMS 201-995 may prove valuable in the treatment of established acute pancreatitis in man.', 'subject score': 1000, 'object score': 851}, 'PMID:2883196': {'publication date': '1987 Jun', 'sentence': 'Postoperatively, a long-acting somatostatin analog, SMS 201-995 (100 micrograms/day), normalized PP secretion acutely and chronically (7 months) and ameliorated his symptoms.', 'subject score': 1000, 'object score': 1000}, 'PMID:2493040': {'publication date': '1989 Mar', 'sentence': 'Heterogeneity of growth hormone (GH) release by individual pituitary adenoma cells from acromegalic patients, as determined by the reverse hemolytic plaque assay: effects of SMS 201-995, GH-releasing hormone and thyrotropin-releasing hormone.', 'subject score': 861, 'object score': 1000}, 'PMID:2822900': {'publication date': '1987 Oct', 'sentence': 'Responses to the mu selective agonist PL 017 were antagonized by the reversible opioid antagonist naloxone and the selective mu antagonist SMS 201-995 in a concentration-dependent fashion.', 'subject score': 861, 'object score': 785}, 'PMID:1293241': {'publication date': '1992 Dec', 'sentence': 'SMS 201-995 reduced the daily ileostomy output from 997 +/- 52 g to 736 +/- 28 g, P < 0.05, along with a decrease in daily sodium and chloride excretion (sodium: 92.60 +/- 8.51 to 75.22 +/- 8.64 mEq, chloride: 143.46 +/- 8.54 to 113.60 +/- 15.84 mEq; both P < 0.05).', 'subject score': 1000, 'object score': 888}, 'PMID:2851522': {'publication date': '1988', 'sentence': 'The use of SMS 201-995 (somatostatin analogue) in insulinomas.', 'subject score': 1000, 'object score': 1000}, 'PMID:2044191': {'publication date': '1991 Jun', 'sentence': 'These results suggest that the effect of SMS 201-995 on pancreatic carcinogenesis in the Syrian hamster is complex and varies with dose administered.', 'subject score': 1000, 'object score': 888}, 'PMID:1380100': {'publication date': '1992 Jun', 'sentence': 'In vitro effect of somatostatin analog, SMS 201-995 (SMS), on pancreatic exocrine secretion was investigated using isolated rat pancreatic acini.', 'subject score': 1000, 'object score': 1000}, 'PMID:2884093': {'publication date': '1986 Dec', 'sentence': 'Our results show that the new somatostatin analogue SMS 201-995 may inhibit GH hypersecretion in acromegalic patients for significant periods, suggesting that this agent can be a useful clinical tool for the treatment of acromegaly.', 'subject score': 864, 'object score': 861}, 'PMID:2160871': {'publication date': '1990 Mar', 'sentence': "Treatment of Cushing's syndrome with the long-acting somatostatin analogue SMS 201-995 (sandostatin).", 'subject score': 841, 'object score': 1000}, 'PMID:2852126': {'publication date': '1988 Aug 20', 'sentence': 'In Patient 1 with glucagonoma syndrome and hypergastrinemia, a prompt and remarkable decrease in plasma IRG and gastrin was observed after the injection of SMS 201-995 in association with a decrease in blood glucose, and then IRG and gastrin increased gradually.', 'subject score': 1000, 'object score': 1000}, 'PMID:2884171': {'publication date': '1987 Apr', 'sentence': 'A dose response study of the effect of an octapeptide somatostatin analogue, SMS 201-995, on meal stimulated gastric acid secretion was carried out in 12 healthy volunteers.', 'subject score': 1000, 'object score': 901}, 'PMID:2461665': {'publication date': '1988 Dec', 'sentence': 'The crisis reaction correlated well with high circulating levels of 5-HT, but after treatment with SMS 201-995 these levels were still high.', 'subject score': 1000, 'object score': 888}, 'PMID:1954873': {'publication date': '1991 Dec', 'sentence': 'All of these effects were completely blocked by SMS 201-995 and L-364,718, with the exception of plasma CCK level by the CCK antagonist.', 'subject score': 1000, 'object score': 623}, 'PMID:1380426': {'publication date': '1992 Sep', 'sentence': 'The present data support the hypothesis that SMS 201-995 is an activator of prostaglandin I2, thereby modifying the course of the disease.', 'subject score': 1000, 'object score': 1000}, 'PMID:2884564': {'publication date': '1987 Jul 02', 'sentence': 'We treated five patients who had thyrotropin-secreting pituitary adenomas with the long-acting somatostatin analogue SMS 201-995, which was administered by subcutaneous injection in doses of 50 to 100 micrograms every 8 to 12 hours.', 'subject score': 841, 'object score': 991}, 'PMID:2884566': {'publication date': '1987 Jul 02', 'sentence': 'Visual improvement with SMS 201-995 in a patient with a thyrotropin-secreting pituitary adenoma.', 'subject score': 1000, 'object score': 1000}, 'PMID:3220051': {'publication date': '1988 Oct', 'sentence': 'Treatment of acromegaly with long acting somatostatin analogue SMS 201-995.', 'subject score': 841, 'object score': 1000}, 'PMID:2884879': {'publication date': '1987 May 29', 'sentence': 'The effect of the long-acting somatostatin analogue SMS 201-995 on exocrine pancreatic function and hormone release was investigated in a double-blind, placebo-controlled study in healthy subjects.', 'subject score': 841, 'object score': 976}, 'PMID:2884881': {'publication date': '1987 May 29', 'sentence': 'Pseudopancreatic cholera syndrome: effect of a synthetic somatostatin analogue, SMS 201-995.', 'subject score': 1000, 'object score': 901}, 'PMID:1923921': {'publication date': '1991 May-Jun', 'sentence': 'SMS 201-995, injected intravenously at 0.5 microgram, did not alter gastric secretion, whereas higher doses (5-20 micrograms) resulted in a dose-related inhibition of gastric acid secretion in conscious pylorus-ligated rats.', 'subject score': 1000, 'object score': 888}, 'PMID:1683501': {'publication date': '1991 Oct', 'sentence': 'The somatostatin analogue SMS 201-995 was found to be a potent inhibitor of the ectopic GHRH and the GH secretion (greater than 500 to 42 ng/l and 15.4 micrograms/l to 0.8 microgram/l, respectively).', 'subject score': 893, 'object score': 888}, 'PMID:2615748': {'publication date': '1989 Nov', 'sentence': '[Long-term effects of treatment with SMS 201-995 on sleep apnea syndrome associated with acromegaly].', 'subject score': 1000, 'object score': 1000}, 'PMID:1381095': {'publication date': '1992', 'sentence': 'MK-329, a CCK receptor antagonist, and SMS 201-995, a somatostatin agonist, were continuously infused at 0.5 mg/kg/h and 5 micrograms/kg/h, respectively, starting at the onset of feeding 70% casein.', 'subject score': 1000, 'object score': 888}, 'PMID:2135020': {'publication date': '1990 Sep', 'sentence': 'Although the mechanism of action of SMS 201-995 in pain remains unclear, the rapid and efficacious analgesic effect of this compound may be one more indication for its use in pituitary tumors associated with cephalalgias.', 'subject score': 1000, 'object score': 1000}, 'PMID:2885995': {'publication date': '1987 Jun', 'sentence': 'The somatostatin analog SMS 201-995 was recently shown to be effective in suppressing GH secretion and in causing tumour shrinkage in patients with GH-secreting pituitary tumours.', 'subject score': 893, 'object score': 861}, 'PMID:1684150': {'publication date': '1991 Dec', 'sentence': 'SMS 201-995 should be useful as a probe into the mechanisms involved in intestinal fluid secretion, but a clinical role in enterotoxigenic gastrointestinal disease was not supported by this study.', 'subject score': 901, 'object score': 1000}, 'PMID:2886085': {'publication date': '1987 Aug', 'sentence': 'We used an octapeptide analogue of somatostatin, SMS 201-995, in dosages ranging from 150 to 450 micrograms/d administered subcutaneously in three daily doses for 1 to 16 months, to treat 22 patients with advanced malignant islet cell carcinomas.', 'subject score': 1000, 'object score': 861}, 'PMID:2676656': {'publication date': '1989 Oct', 'sentence': 'Similarly, stimulation and suppression of beta-cell function with L-leucine and SMS 201-995, respectively, resulted in acceleration and delay of IL-1 beta-mediated inhibition.', 'subject score': 1000, 'object score': 901}, 'PMID:1475626': {'publication date': '1992 Dec', 'sentence': 'The effect of somatostatin analogue SMS 201-995 on serotonin levels in the medium of primary carcinoid cell cultures.', 'subject score': 893, 'object score': 888}, 'PMID:2287871': {'publication date': '1990', 'sentence': 'These results suggest that SMS 201-995 might be useful in the treatment of external biliary fistulas.', 'subject score': 1000, 'object score': 901}, 'PMID:2046904': {'publication date': '1991', 'sentence': 'An effect of long-term treatment with the somatostatin analogue, SMS 201-995, in acromegalic patients.', 'subject score': 1000, 'object score': 861}, 'PMID:1712329': {'publication date': '1991 Aug', 'sentence': 'The antiproliferative effects of the long-acting somatostatin analogue, SMS 201-995 (300 micrograms/kg, t.i.d.), and 2% alpha-difluoromethylornithine on BON xenografts in nude mice were examined.', 'subject score': 1000, 'object score': 852}, 'PMID:1297600': {'publication date': '1992', 'sentence': 'SMS 201-995 was injected subcutaneously with a continuous pump system at a dose of 400 micrograms/d into 4 insulin dependent diabetic patients suffering from proliferative diabetic retinopathy progressing despite a pan-photocoagulation.', 'subject score': 1000, 'object score': 854}, 'PMID:3071597': {'publication date': '1988 Dec', 'sentence': 'These data indicate that treatment with SMS 201-995 might be of value in patients with symptomatic postprandial hypotension.', 'subject score': 1000, 'object score': 1000}, 'PMID:2887309': {'publication date': '1986 Nov', 'sentence': 'A novel potent analogue of somatostatin, the octapepide SMS 201-995 was tested as a therapeutic manoeuvre to prevent hypoglycaemia in patients with insulinoma.', 'subject score': 923, 'object score': 1000}, 'PMID:2887407': {'publication date': '1987 Jul-Aug', 'sentence': 'SMS 201-995 improves glucose tolerance in insulin-treated type II diabetic patients.', 'subject score': 1000, 'object score': 1000}, 'PMID:3071997': {'publication date': '1988 Dec', 'sentence': 'Somatostatin analogue SMS 201-995 in the short-term management of neonatal hyperinsulinism due to nesidioblastosis.', 'subject score': 893, 'object score': 888}, 'PMID:2887504': {'publication date': '1987', 'sentence': 'The effect of a new long-acting somatostatin analog SMS 201-995 (SMS) on hormonal mechanisms controlling the glucose metabolism was tested in 8 type I diabetics over a 3-day period.', 'subject score': 829, 'object score': 1000}, 'PMID:2887718': {'publication date': '1987 Jun 13', 'sentence': '[Usefulness of the somatostatin analog SMS 201-995 in the treatment of gastrinoma].', 'subject score': 893, 'object score': 1000}, 'PMID:2407389': {'publication date': '1990', 'sentence': 'PP was also rapidly suppressed by SMS 201-995 and remained so for 4 hours after the injection.', 'subject score': 1000, 'object score': 1000}, 'PMID:2979211': {'publication date': '1987 Feb', 'sentence': 'Plasma samples of seven patients with gut and pancreatic endocrine tumours who have been on long-term treatment with a long-acting somatostatin analogue (SMS 201-995) were investigated for endogenous antibodies to the peptide by incubation with radiolabelled SMS 201-995.', 'subject score': 1000, 'object score': 916}, 'PMID:2979267': {'publication date': '1988 Oct', 'sentence': 'SMS 201-995 causes a fall in portal pressure without a significant systemic haemodynamic effect.', 'subject score': 1000, 'object score': 1000}, 'PMID:2678621': {'publication date': '1989 Aug', 'sentence': 'Treatment of hypertension, small carbohydrate meals, use of caffeine before a meal or treatment with the somatostatin analogue SMS 201-995 may have a beneficial effect.', 'subject score': 1000, 'object score': 893}, 'PMID:2856504': {'publication date': '1988 Jun', 'sentence': 'Long-term treatment with SMS 201-995 for up to 20 weeks produced excellent clinical control and a decrease in tumour size.', 'subject score': 1000, 'object score': 1000}, 'PMID:2979676': {'publication date': '1987 Aug', 'sentence': 'However, SMS 201-995 impairs carbohydrate tolerance, probably due to inhibition of insulin secretion.', 'subject score': 1000, 'object score': 1000}, 'PMID:2888547': {'publication date': '1986 Dec', 'sentence': 'SMS 201-995 (50 micrograms) given twice daily before meals does not cause a deterioration in metabolic control, does not suppress 24-h GH secretion and causes significant side-effects in patients with non-insulin-dependent diabetes mellitus.', 'subject score': 1000, 'object score': 901}, 'PMID:2888549': {'publication date': '1987 Apr', 'sentence': 'The morphologic findings after SMS 201-995 treatment, are consistent with suppression of GH release.', 'subject score': 916, 'object score': 983}, 'PMID:2888550': {'publication date': '1987 Jul', 'sentence': 'The inhibitory effects of bromocriptine on GH secretion were antagonized by haloperidol, while the inhibitory effect of SMS 201-995 was not affected by the dopamine receptor antagonist.', 'subject score': 1000, 'object score': 1000}, 'PMID:2888554': {'publication date': '1987 Jul', 'sentence': 'Thus SMS 201-995, with preferential effects at the pituitary somatotroph, holds considerable promise as an attractive and viable alternative for treatment of acromegaly.', 'subject score': 923, 'object score': 1000}, 'PMID:2856877': {'publication date': '1985 Jan', 'sentence': 'SMS 201-995 not only controlled the diarrhea without side effects but appeared to have possibly induced a reduction in metastatic tumor size.', 'subject score': 1000, 'object score': 1000}, 'PMID:2435403': {'publication date': '1987 May 01', 'sentence': 'SMS 201-995 is a useful, well-tolerated agent in secreting pancreatic apudomas and to a lesser extent in carcinoid syndrome, where high-dosage regimens may be required.', 'subject score': 1000, 'object score': 861}, 'PMID:2888785': {'publication date': '1987 Oct', 'sentence': 'SMS 201-995 is an excellent drug in patients in whom acromegaly persists after surgery and for interim treatment to shorten the period of clinical activity after irradiation.', 'subject score': 1000, 'object score': 1000}, 'PMID:2918882': {'publication date': '1989 Mar 09', 'sentence': 'Successful pregnancy in a previously infertile woman treated with SMS-201-995 for acromegaly.', 'subject score': 1000, 'object score': 1000}, 'PMID:2319110': {'publication date': '1990 Jan', 'sentence': 'The long-acting somatostatin analogue SMS 201-995 has been used efficaciously in the therapy of metastatic carcinoid tumor, vasoactive intestinal peptide producing islet cell carcinoma, acromegaly, and TSH secreting pituitary tumors.', 'subject score': 841, 'object score': 1000}, 'PMID:2889306': {'publication date': '1987 Sep', 'sentence': 'Thus, in some acromegalic patients continuous sc injection seems currently the most efficient way of treatment with SMS 201-995.', 'subject score': 1000, 'object score': 1000}, 'PMID:2199479': {'publication date': '1990 Aug', 'sentence': 'These data indicate that SMS 201-995 is an effective treatment for refractory acromegaly and for some de novo patients for whom surgical therapy is not advisable.', 'subject score': 1000, 'object score': 888}, 'PMID:2889358': {'publication date': '1987 Sep', 'sentence': 'SMS 201-995 may raise blood pressure, in part by increasing the release of circulating norepinephrine.', 'subject score': 1000, 'object score': 1000}, 'PMID:2919593': {'publication date': '1989 Mar', 'sentence': 'Daily treatment with SMS 201-995, a long-acting somatostatin analogue, for 8 days decreased fistulous output to less than 5 ml/day.', 'subject score': 888, 'object score': 1000}, 'PMID:2889549': {'publication date': '1987 Aug', 'sentence': 'Effects of SMS 201-995 in non-insulin-dependent diabetes.', 'subject score': 1000, 'object score': 1000}, 'PMID:1479200': {'publication date': '1992 Nov-Dec', 'sentence': 'In contrast, combined treatment with hyperthermia and SMS 201-995 failed to enhance cytotoxicity for GH3 cells.', 'subject score': 1000, 'object score': 1000}, 'PMID:3227290': {'publication date': '1988 Sep', 'sentence': 'We conclude that gastrointestinal side effects observed during administration of SMS 201-995 might be related to these motility effects, which warrant further investigation.', 'subject score': 1000, 'object score': 872}, 'PMID:2499481': {'publication date': '1989 Apr', 'sentence': 'The effect of SMS 201-995, a long-acting somatostatin analogue, on splanchnic blood flow and glucose metabolism, was investigated in five groups of healthy subjects.', 'subject score': 852, 'object score': 1000}, 'PMID:2019360': {'publication date': '1991 Jun', 'sentence': 'The 4-nitrobenzo-2-oxa-1,3-diazol-labeled peptide was active in displacing the corresponding hormone 125I-Tyr3-SMS 201-995 (Sandostatin; Sandoz Pharmaceuticals, Basel, Switzerland) from its high-affinity binding site in rat cortex membranes with an IC50 = 4.6 x 10(-10) mol/L.', 'subject score': 802, 'object score': 812}, 'PMID:2858733': {'publication date': '1985 Apr 13', 'sentence': 'Regression of metastatic vipoma with somatostatin analogue SMS 201-995.', 'subject score': 893, 'object score': 861}, 'PMID:2200620': {'publication date': '1990 Jun', 'sentence': 'This dose-finding study shows that 100 micrograms three times daily SMS 201-995 is an effective therapy for most of the acromegalic patients we treated.', 'subject score': 819, 'object score': 861}, 'PMID:3194830': {'publication date': '1988 Dec', 'sentence': 'This suggests that SMS 201-995 decreases local vascular resistance, which results in decreased pancreatic blood flow.', 'subject score': 1000, 'object score': 916}, 'PMID:2622243': {'publication date': '1989 Oct 28', 'sentence': '[Analgesic effect of a somatostatin analog, SMS 201-995, on headache associated with tumor of the hypophysis].', 'subject score': 1000, 'object score': 1000}, 'PMID:2555918': {'publication date': '1989 Oct', 'sentence': "Failure of somatostatin analogue SMS 201-995 to control Cushing's syndrome due to ectopic release of ACTH from a bronchial carcinoid.", 'subject score': 893, 'object score': 1000}, 'PMID:2890795': {'publication date': '1987 Nov', 'sentence': 'Pharmacologic levels of SMS 201,995 and L 363,568 were reliably achieved in portal blood and the latter produced significant reduction (P less than 0.05) in portal venous levels of gastrin.', 'subject score': 888, 'object score': 1000}, 'PMID:2890800': {'publication date': '1987 Oct 17', 'sentence': '[Preoperative treatment of hypoglycemia caused by an insulinoma with the somatostatin analog SMS 201-995].', 'subject score': 893, 'object score': 1000}, 'PMID:2321479': {'publication date': '1990 Feb', 'sentence': 'Effect of the long-acting somatostatin analogue SMS 201-995 on growth rate and reduction of predicted adult height in ten tall adolescents.', 'subject score': 841, 'object score': 802}, 'PMID:2891127': {'publication date': '1987 Apr', 'sentence': 'We suggest there is a use for subcutaneous SMS 201-995 in elderly patients with inoperable pancreatic gut hormone producing tumours with metastases and in those where surgery would carry a high operative risk.', 'subject score': 916, 'object score': 888}, 'PMID:1385097': {'publication date': '1992 Nov', 'sentence': 'Likewise, the administration of SMS 201-995 for 2 and 6 weeks inhibited the E2-induced growth of the anterior pituitary.', 'subject score': 1000, 'object score': 851}, 'PMID:2891202': {'publication date': '1987 Dec', 'sentence': 'This study was undertaken to compare the effects of SRIF and two analogues, SMS 201-995 and L-363,568, on in vitro acid secretion.', 'subject score': 1000, 'object score': 790}, 'PMID:2891203': {'publication date': '1987 Dec', 'sentence': 'Recent studies have documented beneficial effects of the somatostatin analogue, SMS 201-995 (hereafter referred to as SMS), when administered subcutaneously to patients with a variety of disorders.', 'subject score': 1000, 'object score': 1000}, 'PMID:3195610': {'publication date': '1988 Dec', 'sentence': 'Successful treatment of unstable angina in malignant carcinoid syndrome using the long-acting somatostatin analogue SMS 201-995 (Sandostatin).', 'subject score': 888, 'object score': 841}, 'PMID:2891432': {'publication date': '1988 Jan 15', 'sentence': 'Successful treatment with long-acting somatostatin analogue SMS 201-995.', 'subject score': 888, 'object score': 841}, 'PMID:2500900': {'publication date': '1989 Jul', 'sentence': 'SMS 201-995 has been shown to be very useful in the conservative treatment of enterocutaneous fistulas because of its ability to rapidly reduce fistula output and accelerate spontaneous closure.', 'subject score': 1000, 'object score': 983}, 'PMID:2891583': {'publication date': '1988 Jan', 'sentence': 'Successful treatment of idiopathic secretory diarrhea of infancy with the somatostatin analogue SMS 201-995.', 'subject score': 893, 'object score': 901}, 'PMID:1871808': {'publication date': '1991 Aug', 'sentence': 'If present in humans, the appearance of severe glucose intolerance with combined administration of SMS 201-995 and cyclosporine for pancreatic transplantation could be misinterpreted as rejection and lead to inappropriate interventions.', 'subject score': 964, 'object score': 1000}, 'PMID:2860119': {'publication date': '1985 Jun', 'sentence': 'The acute effect of the somatostatin analog SMS 201-995 (SMS) was investigated in eight acromegalic patients.', 'subject score': 893, 'object score': 802}, 'PMID:2166654': {'publication date': '1990 Feb', 'sentence': 'A potent and long-acting somatostatin analogue, SMS 201-995 (SMS) is currently employed for the treatment of various diseases with hypersecretion of hormones such as acromegaly and gastrinoma.', 'subject score': 1000, 'object score': 861}, 'PMID:2140082': {'publication date': '1990 May', 'sentence': 'Thus SMS 201-995 acutely reduces glomerular filtration rate and renal plasma flow in uncomplicated Type 1 diabetes and has an antidiuretic effect.', 'subject score': 923, 'object score': 1000}, 'PMID:2891720': {'publication date': '1988 Jan', 'sentence': 'Two patients, however, did not have GH suppression by SMS 201-995 treatment alone; in 1, a significant decline in mean daily GH was achieved after the addition of bromocriptine.', 'subject score': 916, 'object score': 888}, 'PMID:2891721': {'publication date': '1988 Jan', 'sentence': 'We compared the ability of SRIH and SRIH analog, SMS 201-995 (SMS), to inhibit stimulated GH and TSH secretion in men who received 120-min iv infusions of saline, SRIH (5, 50, and 500 micrograms/h), and SMS (3, 30, and 300 ng/kg.h) together with a bolus iv injection of GHRH (1 microgram/kg) and TRH (500 micrograms).', 'subject score': 1000, 'object score': 1000}, 'PMID:2891808': {'publication date': '1987 Sep-Oct', 'sentence': 'Therapy with the long-acting somatostatin analogue SMS 201-995 was followed by decline in VIP concentrations (900 to 200-300 pg/ml), decrease in stool frequency, and normalization of serum electrolytes.', 'subject score': 1000, 'object score': 841}, 'PMID:2468243': {'publication date': '1989 Feb', 'sentence': 'Attempts to reduce post-transplant pancreatitis in rats and dogs with the somatostatin analogue SMS 201-995.', 'subject score': 893, 'object score': 1000}, 'PMID:2860768': {'publication date': '1985 May', 'sentence': 'In the rat chondrosarcoma, the effect of SMS 201-995 is probably indirect, due to inhibition of GH, somatomedin and insulin.', 'subject score': 1000, 'object score': 1000}, 'PMID:1839344': {'publication date': '1991', 'sentence': 'SMS 201-995 had no influence on basal plasma GH levels, but significantly inhibited the hGHRH and clonidine-evoked GH release.', 'subject score': 1000, 'object score': 775}, 'PMID:2892248': {'publication date': '1987 Nov', 'sentence': 'The effect of intravenous bolus injection of the somatostatin analogue SMS 201-995 on mucosal and submucosal blood flow was studied with the local 133Xe clearance technique in eight subjects.', 'subject score': 893, 'object score': 1000}, 'PMID:2892335': {'publication date': '1987', 'sentence': 'SMS 201-995 is active orally at doses of 4-8 mg and when given thrice-daily to 6 patients with active acromegaly, suppressed mean 24-h growth hormone levels by 51-88%.', 'subject score': 1000, 'object score': 861}, 'PMID:3009249': {'publication date': '1986 Apr', 'sentence': 'Somatostatin receptors have been visualized in the adrenal by autoradiography using the iodinated Tyr3 derivative of the somatostatin octapeptide analog SMS 201-995 (H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr(ol), Sandostatin*).', 'subject score': 1000, 'object score': 834}, 'PMID:3231042': {'publication date': '1988 Jul-Sep', 'sentence': '[Role of a prolonged-action analog of somatostatin SMS 201-995 in the therapy of type 2 diabetes mellitus].', 'subject score': 916, 'object score': 1000}, 'PMID:2892599': {'publication date': '1987 Sep', 'sentence': 'Continuous subcutaneous pump infusion of somatostatin analogue SMS 201-995 versus subcutaneous injection schedule in acromegalic patients.', 'subject score': 893, 'object score': 861}, 'PMID:2683738': {'publication date': '1989 Nov', 'sentence': 'On the other hand, SMS 201-995 (50 micrograms, sc) almost completely inhibited both bombesin-induced CCK secretion and gallbladder contraction (maximum contractile rate, 93.6 +/- 6.2%).', 'subject score': 1000, 'object score': 833}, 'PMID:1360663': {'publication date': '1992 Dec 01', 'sentence': 'In contrast, the somatostatin analogs SMS 201-995, IM 4-28, and MK-678 failed to displace specific binding in transfected cells.', 'subject score': 861, 'object score': 886}, 'PMID:2893369': {'publication date': '1987 Dec 19', 'sentence': 'It was necessary to increase the dosage (300-400 micrograms/24 hours) and to alter the mode of administration (continuous subcutaneous infusion) to obtain a clinical benefit inferior to that obtained during the first year of treatment with SMS 201-995.', 'subject score': 1000, 'object score': 1000}, 'PMID:2893447': {'publication date': '1987 Dec', 'sentence': 'SMS 201-995 had no effect on Na+/Ca++ exchange but significantly inhibited basolateral ATP-dependent Ca++ transport (-40% +/- 5%, p less than 0.005).', 'subject score': 1000, 'object score': 798}, 'PMID:2893555': {'publication date': '1988 Jan', 'sentence': 'The purpose of this study was to determine whether SMS 201-995, a long-acting analog, would inhibit the growth of pancreatic adenocarcinomas.', 'subject score': 1000, 'object score': 1000}, 'PMID:2893592': {'publication date': '1988 Feb', 'sentence': 'SMS 201-995 is a powerful therapeutic agent for the management of patients suffering from the dumping syndrome after gastric surgery.', 'subject score': 1000, 'object score': 1000}, 'PMID:2893673': {'publication date': '1987 Oct', 'sentence': 'Acute suppression of insulin secretion from pancreatic insulinomas by long-acting somatostatin analogue SMS 201-995 has been documented.', 'subject score': 841, 'object score': 1000}, 'PMID:1902408': {'publication date': '1991 Feb', 'sentence': 'Ten acromegalic subjects were studied in a trial designed to ascertain the optimum dosage of the somatostatin analogue SMS 201-995 (octreotide) in active acromegaly.', 'subject score': 893, 'object score': 888}, 'PMID:2592740': {'publication date': '1989 Sep', 'sentence': 'The data illustrate that the applicability of the generally held cut-off value of 5 micrograms/l, between normal and abnormal plasma GH, has to be reconsidered in the case of chronic intermittent subcutaneous therapy with SMS 201-995.', 'subject score': 833, 'object score': 1000}, 'PMID:2684694': {'publication date': '1989 Jul 20', 'sentence': '[A multicenter clinical trial of SMS 201-995 (octreotide acetate) in acromegaly and gigantism].', 'subject score': 1000, 'object score': 1000}, 'PMID:2168344': {'publication date': '1990 Sep 15', 'sentence': 'Somatostatin receptors (SS-R) were measured with in vitro receptor autoradiography using the SS analog 125I-[Tyr3]-SMS 201-995 as radioligand in 342 breast-tumor samples.', 'subject score': 813, 'object score': 1000}, 'PMID:2235686': {'publication date': '1990 Jul-Aug', 'sentence': 'The influence of the long-acting somatostatin analogue, SMS 201-995, on FMLP-induced neutrophil elastase release in vitro has been investigated.', 'subject score': 1000, 'object score': 861}, 'PMID:1902881': {'publication date': '1991 Jan 22', 'sentence': 'We conclude that 1) treatment with SMS 201-995 in patients resistant to other forms of therapy may be less successful than previously reported for heterogenous groups of patients; 2) the dose regimen must be adapted to the individual patient for optimal effect and most of our patients needed higher doses than 300 micrograms daily; 3) 4 or maybe more daily injections or CSI seem to be most effective; and 4) in a minority of patients SMS has no influence on GH-secretion.', 'subject score': 1000, 'object score': 1000}, 'PMID:1902962': {'publication date': '1991 Jan', 'sentence': 'Acromegalic patients do not respond with the same degree of growth hormone (GH) inhibition to long-term therapy with the somatostatin analogue SMS 201-995.', 'subject score': 893, 'object score': 901}, 'PMID:2894314': {'publication date': '1987 Dec 15', 'sentence': 'Intracerebroventricular (i.c.v.) administration of somatostatin or SMS 201-995 induces excessive grooming behavior in rats.', 'subject score': 1000, 'object score': 1000}, 'PMID:2894388': {'publication date': '1987 Dec', 'sentence': 'Native somatostatin (SRIF) and the synthetic analog SMS 201-995 inhibited insulin secretion from all cultures.', 'subject score': 854, 'object score': 1000}, 'PMID:2894481': {'publication date': '1988 Jan 15', 'sentence': 'SMS 201-995 not only gave symptomatic relief but also induced a reduction in metastatic tumor mass.', 'subject score': 1000, 'object score': 901}, 'PMID:2863230': {'publication date': '1985 Jun', 'sentence': 'Assignment of the 1H 500 MHZ n.m.r. spectra and conformational analysis of SMS 201-995 in dimethylsulfoxide.', 'subject score': 1000, 'object score': 1000}, 'PMID:2863231': {'publication date': '1985 Jun', 'sentence': 'In SMS 201-995 the beta turn/beta sheet conformation is stabilized by the additional amino-acids D-Phe1 and Thr8 (ol) through intramolecular H-bonds.', 'subject score': 901, 'object score': 1000}, 'PMID:1328199': {'publication date': '1992 Oct 05', 'sentence': 'mSSTR3 binds somatostatin-14 and somatostatin-28 with high affinity, but shows very low affinity for the somatostatin analogs MK-678 and SMS-201-995.', 'subject score': 1000, 'object score': 1000}, 'PMID:2895119': {'publication date': '1988 Mar', 'sentence': 'We conclude that SMS 201-995 may be a valuable therapeutic agent for the management of patients with a thyrotroph adenoma.', 'subject score': 1000, 'object score': 1000}, 'PMID:2355767': {'publication date': '1990 Apr 07', 'sentence': '[Usefulness of the somatostatin analog SMS 201-995 in the treatment of diarrhea in patients infected with the human immunodeficiency virus].', 'subject score': 893, 'object score': 1000}, 'PMID:2169342': {'publication date': '1990 Oct 01', 'sentence': 'Using a stable cell line derived from the long-term experiment and designated 7315c, we show that (a) long-term exposure of 7315c cells to SMS 201-995 leads to loss of sensitivity with respect to both rPRL secretion and cell growth, (b) this loss of sensitivity is accompanied by complete disappearance of the somatostatin receptors from the cells, (c) withdrawal of treatment from desensitized cells leads to reappearance of receptors and of sensitivity to SMS 201-995, showing that selection for a non-receptor-bearing population was not the cause of desensitization, and (d) since these experiments were carried out with a pure population of 7315c cells the effects of SMS 201-995 are direct effects on these cells and not effects mediated by other cell or organ systems.', 'subject score': 1000, 'object score': 1000}, 'PMID:2895501': {'publication date': '1988 Apr', 'sentence': 'The inhibitory action of SMS 201-995 on pancreatic secretion and hormone releases was dose dependent.', 'subject score': 1000, 'object score': 1000}, 'PMID:2804808': {'publication date': '1989 Nov', 'sentence': 'Furthermore, SMS 201-995 may relieve intractable headache in some acromegalic patients, but tolerance to the analgesic effect may develop.', 'subject score': 1000, 'object score': 1000}, 'PMID:2687064': {'publication date': '1989 Nov', 'sentence': 'While the rises in plasma non-esterified fatty acid and glycerol levels were not reduced by SMS 201-995, the increase in plasma 3-hydroxbutyrate levels, although similar from 23.00 to 02.00 hours, was significantly reduced from 02.00 to 05.00 hours (+77 +/- 20 vs +124 +/- 31 mumols.l-1.h-1; p less than 0.05).', 'subject score': 818, 'object score': 1000}, 'PMID:2087492': {'publication date': '1990 Nov', 'sentence': 'Desulfated cerulein did not affect the barrel rotation induced by SMS 201-995.', 'subject score': 861, 'object score': 1000}, 'PMID:2896138': {'publication date': '1988 Jun', 'sentence': 'Unlike treatment with epinephrine, pretreatment of tissues with SMS 201-995 did not directly inhibit electrogenic anion secretion stimulated by vasoactive intestinal polypeptide, calcium ionophore A23187, and bethanechol.', 'subject score': 1000, 'object score': 1000}, 'PMID:2896207': {'publication date': '1988 Jan', 'sentence': 'However, before SMS 201-995 is employed in the management of acromegalic patients refractory to surgery and bromocriptine therapy, we need further observations of postprandial glycemic profiles during long-term therapy with multiple daily injections of the compound.', 'subject score': 1000, 'object score': 861}, 'PMID:1935786': {'publication date': '1991 Nov', 'sentence': 'SMS 201-995 significantly reduced the MCF-7 cell growth induced by serum, estradiol, insulin, and insulin-like growth Factor-I in both short term and long term experiments.', 'subject score': 1000, 'object score': 916}, 'PMID:2896307': {'publication date': '1988 Apr', 'sentence': 'Successful symptomatic treatment of malignant carcinoid syndrome with the somatostatin analogue SMS 201-995.', 'subject score': 893, 'object score': 1000}, 'PMID:2896344': {'publication date': '1988', 'sentence': 'The chronic intracerebroventricular infusion of the somatostatin analogue SMS 201-995 resulted in a significant increase in daily food intake which was accompanied by an unexpected body weight loss.', 'subject score': 893, 'object score': 901}, 'PMID:1967176': {'publication date': '1990 Jan', 'sentence': 'Also, in this case the prolonged treatment of patients with SMS 201995 leads to an impaired chemotactic response.', 'subject score': 1000, 'object score': 1000}, 'PMID:2986771': {'publication date': '1985 Apr 29', 'sentence': '[125I-Tyr11]somatostatin-14 as well as iodinated D-Tyr1 and Tyr3 derivatives of the cyclic octapeptide somatostatin analog, SMS 201-995 (H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-ol) have been used as radioligands for somatostatin receptor autoradiography in rat brain.', 'subject score': 888, 'object score': 1000}, 'PMID:1364090': {'publication date': '1992 Sep-Oct', 'sentence': 'In tissues of 31 tumors (20 carcinoid, eight islet-cell carcinoma, three medullary thyroid carcinomas), the presence of somatostatin receptors was analyzed by binding of the somatostatin analog 125I-Tyr3-SMS 201-995 and autoradiography.', 'subject score': 1000, 'object score': 811}, 'PMID:2535688': {'publication date': '1989 Jan 01', 'sentence': 'Whether SMS 201-995 has a significant effect on gut neuroendocrine tumor growth remains uncertain.', 'subject score': 1000, 'object score': 861}, 'PMID:2505955': {'publication date': '1989 Jan', 'sentence': 'The GH responses to TRH and to the somatostatin analogue SMS 201-995 were also studied in acromegalic patients.', 'subject score': 893, 'object score': 861}, 'PMID:1967933': {'publication date': '1990 Jan 01', 'sentence': 'In addition, the analogue SMS 201-995 inhibited the forskolin-stimulated adenylate cyclase activity in bone cell suspensions.', 'subject score': 916, 'object score': 850}, 'PMID:2866012': {'publication date': '1985 Nov', 'sentence': 'The results suggest that SMS 201-995 may be of value in the control of bleeding oesophageal varices.', 'subject score': 1000, 'object score': 1000}, 'PMID:2897419': {'publication date': '1988 Jan', 'sentence': '[Successful therapy of VIPoma with the long-acting somatostatin analogue SMS 201-995].', 'subject score': 841, 'object score': 1000}, 'PMID:2866445': {'publication date': '1985 Dec 19', 'sentence': 'These preliminary results suggest that SMS 201-995 represents an additional option for the management of acromegaly, especially in patients who do not benefit sufficiently from surgery or radiotherapy and do not respond well to treatment with dopaminergic drugs.', 'subject score': 1000, 'object score': 1000}, 'PMID:1968417': {'publication date': '1990 Jan', 'sentence': 'Effect of the somatostatin analogue SMS 201-995 on faecal fat excretion in acromegaly.', 'subject score': 893, 'object score': 901}, 'PMID:1968467': {'publication date': '1990 Mar', 'sentence': 'Analogs Ac-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-NH2 (RC-101-I) as well as RC-121, RC-160, and RC-95-I, but not SMS-201-995, showed high binding affinity in human breast cancers.', 'subject score': 916, 'object score': 890}, 'PMID:2472826': {'publication date': '1989', 'sentence': 'With regard to these data chemotherapy and interferons seem to be equally potent in the treatment of malignant endocrine pancreatic tumors, whereas interferons seem to be superior to both chemotherapy and the somatostatin analogue SMS 201-995 in malignant carcinoid tumors.', 'subject score': 893, 'object score': 988}, 'PMID:2897974': {'publication date': '1988 Jul', 'sentence': 'We measured plasma insulin-like growth factor I/somatomedin-C (IGF-I/SmC) concentrations and mean 24-h GH secretion serially before and during therapy with the long-acting somatostatin analog SMS 201-995 in 21 patients with acromegaly.', 'subject score': 1000, 'object score': 841}, 'PMID:2807148': {'publication date': '1989 Oct', 'sentence': 'Effects of short-term subcutaneous administration of SMS 201-995 on calcitonin plasma levels in patients suffering from medullary thyroid carcinoma.', 'subject score': 1000, 'object score': 1000}, 'PMID:2597971': {'publication date': '1989 Nov', 'sentence': 'Further studies are required to delineate more precisely the mechanism whereby SMS 201-995 inhibits the growth of hepatic tumour derived from intraportal administration of Walker cells.', 'subject score': 850, 'object score': 1000}, 'PMID:1517658': {'publication date': '1992 Jun', 'sentence': 'This experiment demonstrated that SMS 201-995 has a strong inhibitory effect on pancreatic exocrine function, markedly reducing the amount of fistula fluid and the production of amylase, total protein, and bicarbonate.', 'subject score': 1000, 'object score': 913}, 'PMID:2473000': {'publication date': '1989 Aug', 'sentence': 'Gastrin production by the tumor was stimulated by secretin and inhibited by the long-acting somatostatin analogue SMS 201-995.', 'subject score': 888, 'object score': 841}, 'PMID:2690316': {'publication date': '1989 Dec', 'sentence': 'The aim of this study was to examine the effect of SMS 201-995 on fat assimilation in healthy subjects, using 14C-triolein and 3H-oleic acid as tracers of dietary triglycerides and free fatty acids, respectively, and 51CrCl3 as non-absorbable marker.', 'subject score': 861, 'object score': 1000}, 'PMID:2898862': {'publication date': '1988 May', 'sentence': 'Long-term use of somatostatin analogue SMS 201-995 in the treatment of hypoglycaemia due to nesidioblastosis.', 'subject score': 893, 'object score': 1000}, 'PMID:2867801': {'publication date': '1985 Dec', 'sentence': 'It is suggested that SMS 201-995 may be of value in stimulating RES activity in patients with cirrhosis and portal hypertension.', 'subject score': 1000, 'object score': 1000}, 'PMID:2867802': {'publication date': '1985 Dec', 'sentence': 'Furthermore, because of its prolonged duration of action SMS 201-995 may be useful in the long term management of portal hypertension in patients with cirrhosis.', 'subject score': 923, 'object score': 1000}, 'PMID:2899019': {'publication date': '1988 May', 'sentence': 'Effect of SMS 201-995 in rapidly progressive diabetic retinopathy.', 'subject score': 1000, 'object score': 824}, 'PMID:2899089': {'publication date': '1988 Aug', 'sentence': 'SMS 201-995 was an effective medical treatment for acromegaly caused by ectopic GHRH production in this patient.', 'subject score': 1000, 'object score': 1000}, 'PMID:2172125': {'publication date': '1990 Jul', 'sentence': 'SMS 201-995 is useful for the symptomatic treatment of patients with neuroendocrine gut tumors.', 'subject score': 1000, 'object score': 1000}, 'PMID:2899298': {'publication date': '1988 Jun', 'sentence': 'Successful treatment of ophthalmoplegia in acromegaly with the somatostatin analogue SMS 201-995.', 'subject score': 893, 'object score': 1000}, 'PMID:2691013': {'publication date': '1989 Dec', 'sentence': 'The effect of long acting somatostatin analogue, SMS 201-995, on postprandial dumping syndrome was studied in eight patients with Billroth II gastric resection.', 'subject score': 1000, 'object score': 852}, 'PMID:2563240': {'publication date': '1989 Feb', 'sentence': 'In this study we used the AR4-2J rat pancreatic acinar tumor cell line to investigate the effect of a stable somatostatin analog, SMS 201-995 (SMS) on cell proliferation.', 'subject score': 1000, 'object score': 901}, 'PMID:2899530': {'publication date': '1988 Sep', 'sentence': 'They also may represent an explantation at the molecular level for the lack of therapeutic effect of somatostatin analogues such as SMS 201-995 seen in patients with advanced exocrine pancreatic carcinomas.', 'subject score': 1000, 'object score': 1000}, 'PMID:2563303': {'publication date': '1989 Jan', 'sentence': 'Acute treatment of wild-type S49 cells with the somatostatin analog SMS 201-995 (SMS) results in inhibition of cAMP accumulation.', 'subject score': 893, 'object score': 775}, 'PMID:2899658': {'publication date': '1988 Apr 16', 'sentence': '[Management of insulinoma with the somatostatin analog SMS 201-995].', 'subject score': 893, 'object score': 1000}, 'PMID:2899940': {'publication date': '1988 Aug', 'sentence': 'The study suggests that SMS 201-995 may be useful in the treatment of patients with gonadotrope cell adenomas.', 'subject score': 1000, 'object score': 1000}, 'PMID:1970540': {'publication date': '1990 May', 'sentence': 'Moreover, we studied the effect of somatostatin analogue SMS 201-995 on glucose-induced IAPP secretion in nondiabetic subjects.', 'subject score': 893, 'object score': 851}, 'PMID:2537716': {'publication date': '1989 Mar', 'sentence': 'The effect of SMS 201-995 on tumor size has been assessed in 46 patients, less than 20% of whom showed a reduction in tumor size.', 'subject score': 1000, 'object score': 861}, 'PMID:2900189': {'publication date': '1988', 'sentence': 'It is concluded that chronic therapy with SMS 201-995 represents a promising medical alternative for the treatment of active acromegaly.', 'subject score': 888, 'object score': 1000}, 'PMID:2900201': {'publication date': '1988', 'sentence': 'The octapeptide SMS 201-995 was described as a potent inhibitor of gastric secretion in comparison with natural somatostatin in rats and also in humans, but was unable to induce maximal suppression of acid output in the cat model.', 'subject score': 923, 'object score': 888}, 'PMID:2302002': {'publication date': '1990 Feb', 'sentence': 'Treatment of 27 postoperative enterocutaneous fistulas with the long half-life somatostatin analogue SMS 201-995.', 'subject score': 845, 'object score': 858}, 'PMID:2900585': {'publication date': '1988 Mar', 'sentence': '[Treatment of chronic non-secretory diarrhea in ileostomy with the long-acting somatostatin analog SMS 201-995].', 'subject score': 1000, 'object score': 841}, 'PMID:2361459': {'publication date': '1990 Mar', 'sentence': 'In conclusion our data show that SMS 201-995 is a very effective medical treatment in acromegalic patients.', 'subject score': 1000, 'object score': 861}, 'PMID:2361474': {'publication date': '1990 Jul', 'sentence': 'In this study we evaluate the effects of iv and id infusion of a long acting analog of SRIF, SMS 201-995 (SMS), on pancreatic secretion during basal conditions (pancreatic juice returned) and PJD.', 'subject score': 1000, 'object score': 1000}, 'PMID:2809722': {'publication date': '1989 Nov', 'sentence': 'These data demonstrate that SMS 201-995 can rapidly improve the chiasmal syndrome due to pituitary macroadenoma, and suggest that this effect might be independent of a reduction in tumor volume.', 'subject score': 1000, 'object score': 1000}, 'PMID:2331811': {'publication date': '1990 Jan', 'sentence': 'In addition, plasma IR-7B2 levels did not change significantly after the administration of SMS 201-995 in normal subjects or in patients with primary hypothyroidism in whom SMS 201-995 induced a decrease of plasma TSH levels.', 'subject score': 1000, 'object score': 1000}, 'PMID:2063026': {'publication date': '1991 Jan', 'sentence': '[The pharmacological treatment of digestive endocrine tumors with the somatostatin analog SMS 201-995].', 'subject score': 893, 'object score': 890}, 'PMID:2901281': {'publication date': '1988 Jul', 'sentence': 'Treatment of pancreatic fistula with the somatostatin analogue SMS 201-995.', 'subject score': 893, 'object score': 1000}, 'PMID:2901329': {'publication date': '1988 Jul 13', 'sentence': 'The effects of the somatostatin analogue SMS 201-995 on carbohydrate homeostasis of insulin-dependent diabetics as assessed by the artificial endocrine pancreas.', 'subject score': 893, 'object score': 888}, 'PMID:3048792': {'publication date': '1988 Jan', 'sentence': 'Furthermore, SMS 201-995 failed to inhibit the stimulation of PA secretion induced by exogenous angiotensin-II (2-10 ng/kg/min).', 'subject score': 901, 'object score': 1000}, 'PMID:2870915': {'publication date': '1986 Jun', 'sentence': 'Exposure of the 7315a tumor to high glucocorticosteroid levels probably decreases the number of somatostatin receptors, diminishing the possible direct antitumor effect of SMS 201-995.', 'subject score': 1000, 'object score': 1000}, 'PMID:2870957': {'publication date': '1986 May', 'sentence': 'The effect of oral lidamidine hydrochloride and subcutaneous long acting somatostatin analogue, SMS 201-995, on stool output and salt and water transport in the small intestine was investigated in a patient with gross secretory diarrhoea caused by a vasoactive intestinal polypeptide (VIP) secreting tumour in the liver.', 'subject score': 1000, 'object score': 851}, 'PMID:2871221': {'publication date': '1986 Apr 15', 'sentence': 'It is concluded that SMS 201-995 offers new possibilities in the treatment of acromegaly.', 'subject score': 1000, 'object score': 1000}, 'PMID:1941488': {'publication date': '1991 Sep', 'sentence': 'The use of SMS 201-995 as an adjunct in the successful closure of intestinal fistulae in an infant is reported.', 'subject score': 1000, 'object score': 1000}, 'PMID:2121494': {'publication date': '1990 Aug', 'sentence': 'It is concluded that despite a blunted release of the trophic hormone CCK, long-term treatment with SMS 201-995 neither induces an abnormally small pancreas nor deterioration of postprandial exocrine pancreatic function in patients with acromegaly.', 'subject score': 1000, 'object score': 1000}, 'PMID:1973122': {'publication date': '1990 Apr', 'sentence': 'Severe clinical and biochemical signs of hypoglycaemia were registered on one occasion only during the first month of treatment with SMS 201-995.', 'subject score': 1000, 'object score': 1000}, 'PMID:2539768': {'publication date': '1989 Jan-Feb', 'sentence': 'This first report on SMS 201-995 treatment of breast cancer suggests that further studies evaluating the effect of other modes of administration or drug association should be warranted.', 'subject score': 916, 'object score': 1000}, 'PMID:2566573': {'publication date': '1989', 'sentence': 'Furthermore, SRIF-binding sites were undetectable in a patient which did not respond to SMS 201995 therapy.', 'subject score': 901, 'object score': 1000}, 'PMID:2812196': {'publication date': '1989', 'sentence': 'The somatostatin analogue SMS 201-995 promotes paradoxical sleep in aged rats.', 'subject score': 893, 'object score': 1000}, 'PMID:2511221': {'publication date': '1989 Dec', 'sentence': 'Acute GH responses to GHRH-44 (0.1, 0.33, and 1.0 micrograms/kg BW, iv) were measured, and GH secretion during therapy with the long-acting somatostatin analog SMS 201-995 (Sandoz) was assessed.', 'subject score': 1000, 'object score': 841}, 'PMID:2903168': {'publication date': '1988 Nov', 'sentence': 'Preoperative treatment of acromegaly with long-acting somatostatin analog SMS 201-995: shrinkage of invasive pituitary macroadenomas and improved surgical remission rate.', 'subject score': 841, 'object score': 1000}, 'PMID:1665529': {'publication date': '1991 Dec 11', 'sentence': 'Interferon alfa 2b (Intron A, Essex Pharma) and the somatostatin-analogue SMS 201-995 (Sandostatin, Sandoz) had no effect on catecholamine production and progression of the tumor.', 'subject score': 893, 'object score': 888}, 'PMID:2872225': {'publication date': '1986 Jul', 'sentence': 'In addition, the combination of SMS 201-995 and bromocriptine can be of value in a few acromegalic patients who do not respond to either drug alone.', 'subject score': 1000, 'object score': 802}, 'PMID:2872284': {'publication date': '1986 Jul', 'sentence': 'This study demonstrates the safety and efficacy of SMS 201-995 in the short-term treatment of acromegaly.', 'subject score': 1000, 'object score': 1000}, 'PMID:2903562': {'publication date': '1988 Nov', 'sentence': 'Treatment with SMS 201-995 in three patients for 5 months decreased tumor secretion of gastrin and diminished basal acid secretion, an effect that persisted in two of three patients 48 hours after withdrawal of SMS.', 'subject score': 1000, 'object score': 888}, 'PMID:2872408': {'publication date': '1986 May 31', 'sentence': 'Rapid improvement in sleep apnoea of acromegaly after short-term treatment with somatostatin analogue SMS 201-995.', 'subject score': 893, 'object score': 1000}, 'PMID:2872592': {'publication date': '1986 Jun 26', 'sentence': 'Treatment of inoperable glucagonoma with the long-acting somatostatin analogue SMS 201-995.', 'subject score': 841, 'object score': 888}, 'PMID:1522942': {'publication date': '1992 Mar-Apr', 'sentence': "The 24-h growth hormone secretory pattern and GH response to growth hormone releasing hormone, the alpha 2-adrenoceptor agonist clonidine and the somatostatin-analogue SMS 201-995 were evaluated in 9 patients with Alzheimer's disease and 9 age- and body body-matched control subjects.", 'subject score': 893, 'object score': 861}, 'PMID:1398464': {'publication date': '1992 May', 'sentence': 'After 3 days of continuous subcutaneous infusion (CSI) of SMS 201-995 in 9 acromegalic patients (100 micrograms/24 h) a slight but significant decrease in serum total triiodothyronine (TT3) and a concomitant increase in serum TSH were demonstrated, indicating an initial inhibitory effect on peripheral deiodination of thyroxine.', 'subject score': 1000, 'object score': 901}, 'PMID:2177234': {'publication date': '1990 Dec 17', 'sentence': 'It is suggested that there is a use for subcutaneous SMS 201-995 in elderly patients with inoperable pancreatic gut hormone producing tumours with metastasis and in those in whom surgery would involve a high operative risk.', 'subject score': 916, 'object score': 888}, 'PMID:2569769': {'publication date': '1989 Aug', 'sentence': 'Minced tumor fragments were xenografted into subcutaneous tissue of the lateral thoracic regions of young adult, virgin female nude mice to study the effects of somatostatin analog SMS 201-995 on growth of estrogen-dependent (MCF-7) and estrogen-independent (BT-20) human breast carcinomas.', 'subject score': 893, 'object score': 1000}, 'PMID:2543178': {'publication date': '1989 Jun', 'sentence': "SMS 201-995 did not affect plasma ACTH and cortisol levels in three patients with untreated Cushing's disease.", 'subject score': 1000, 'object score': 888}, 'PMID:2573010': {'publication date': '1989 Sep 25', 'sentence': 'These results suggest that the SRIF-specific stimulation of adenylate cyclase may be a functional correlate for the brain-specific SRIF receptor subpopulation, whereas the SRIF and SMS 201-995 inhibition of stimulated adenylate cyclase correlate with the SRIF receptor subpopulation present in brain and non-neuronal tissues.', 'subject score': 916, 'object score': 901}, 'PMID:1702388': {'publication date': '1990 Oct', 'sentence': 'SMS 201-995 effectively prevents or at least improves flush and diarrhoea in the carcinoid syndrome, disabling diarrhoea in the Verner-Morrison syndrome and migratory erythema in the glucagonoma syndrome.', 'subject score': 1000, 'object score': 1000}, 'PMID:1342235': {'publication date': '1992', 'sentence': 'The effect of the long-acting somatostatin analogue SMS-201995 on diabetes control was assessed in 6 insulin-dependent diabetic patients (3 men and 3 women aged 19-38 years).', 'subject score': 833, 'object score': 888}, 'PMID:6150888': {'publication date': '1984 Oct', 'sentence': 'SMS 201-995 inhibited acid secretion in a dose-dependent manner.', 'subject score': 1000, 'object score': 1000}, 'PMID:10022504': {'publication date': '1999 Feb 01', 'sentence': 'However, in membrane preparations obtained from mitogen-activated cells, the maximal inhibition of adenylyl cyclase mediated by SRIF14 and SRIF28 equaled only one third of that measured in the absence of mitogens, whereas SMS 201-995 was completely inactive.', 'subject score': 1000, 'object score': 1000}, 'PMID:9818792': {'publication date': '1998 Sep', 'sentence': 'Evidence that SMS 201-995 enhances the immunosuppressive effect of FK506.', 'subject score': 1000, 'object score': 1000}, 'PMID:9927304': {'publication date': '1999 Feb', 'sentence': 'Somatostatin (SS-14) and its structural analogue SMS 201-995 (SMS) are recognized as physiological inhibitors of multiple organs and tissue functions through specific membrane receptors (sst1-sst5).', 'subject score': 854, 'object score': 872}, 'PMID:6198981': {'publication date': '1983 Nov', 'sentence': 'These results indicate that N-methylnaloxone and SMS 201-995 can block the peripheral receptors which mediate opiate-induced bradycardia.', 'subject score': 1000, 'object score': 851}, 'PMID:6148524': {'publication date': '1984 Oct 06', 'sentence': 'In the remaining patient who had very high basal preprandial serum GH, SMS 201-995 produced a reduction in serum GH of only 20%.', 'subject score': 1000, 'object score': 901}, 'PMID:7530798': {'publication date': '1995', 'sentence': 'This implies that SST analogs like SMS 201-995, known to interact with SSTR2A, but not with SSTR1, act on pituitary tumors mainly via the SSTR2 subtype.', 'subject score': 1000, 'object score': 1000}, 'PMID:7951857': {'publication date': '1994 Aug', 'sentence': 'It was concluded that combination therapy with SMS 201-995 and low-dose isosorbide dinitrate may be beneficial for portal hypertension in liver cirrhosis.', 'subject score': 1000, 'object score': 1000}, 'PMID:7802970': {'publication date': '1994 Jul', 'sentence': 'Whereas (SS1) binding sites for the octapeptide analogue Tyr3-SMS-201-995 appear to be absent in the gymnotiform brain, (SS2) binding sites for the analogue [Tyr0-D-Trp8]-somatostatin-14 were found in many brain regions and showed a similar distribution to that observed by other authors in the amphibian and mammalian central nervous system.', 'subject score': 861, 'object score': 817}, 'PMID:7982482': {'publication date': '1994 Nov 28', 'sentence': 'These results suggest that somatostatin-induced inhibition of HVA Ca2+ currents is mediated by a specific receptor subtype and that inhibition of calcium influx through HVA Ca2+ channels is one of the mechanisms of SMS 201-995 action on inhibitory processes of hormone secretion and cell proliferation.', 'subject score': 1000, 'object score': 756}, 'PMID:8132773': {'publication date': '1994 Mar', 'sentence': 'Since SMS 201-995 was effective in the treatment of a patient with glucagonoma in which SSTR2 mRNA was present, but had no effect in a patient with carcinoid in which SSTR2 mRNA was not detected, this study suggests that the efficacy of SMS 201-995 may depend, at least in part, on the expression of SSTR2 in tumors.', 'subject score': 1000, 'object score': 1000}, 'PMID:8078491': {'publication date': '1994 Aug', 'sentence': 'However, the clinically used SRIF analogue SMS 201-995, which potently inhibited cAMP formation via interaction with rat SSTR5, did not inhibit cAMP accumulation in cells expressing human SSTR5.', 'subject score': 794, 'object score': 763}, 'PMID:10765004': {'publication date': '1999 Sep-Dec', 'sentence': 'To examine the additive effect of octreotide, the synthetic long-acting somatostatin analogue SMS 201-995, to conventional treatment of manifest DKA, we compared the correction time of acidosis, ketonuria, and hyperglycemia of patients treated with an intravenous infusion of low-dose insulin (4 units per hour) plus subcutaneous injection of octreotide (50 microg every 6 hours) by low-dose insulin alone.', 'subject score': 801, 'object score': 1000}, 'PMID:7686764': {'publication date': '1993', 'sentence': 'Octreotide, SMS 201-995 (Sandostatin), was escalated in doses ranging from 1,500 micrograms to 6,000 micrograms daily in 14 patients with carcinoid.', 'subject score': 1000, 'object score': 861}, 'PMID:8320851': {'publication date': '1993 May', 'sentence': '[Inhibitory effect of somatostatin analogue, SMS 201-995, on secretin-stimulated exocrine secretion in isolated perfused rat pancreas].', 'subject score': 825, 'object score': 1000}, 'PMID:8020889': {'publication date': '1994 Jul', 'sentence': 'Multiple-indicator dilution experiments in presence of increasing cholyltaurine concentrations suggested an interaction of SMS 201-995 with sinusoidal bile salt transport.', 'subject score': 658, 'object score': 1000}, 'PMID:7750900': {'publication date': '1995 Apr', 'sentence': 'We previously reported that the octapeptide somatostatin (SS) analogue SMS 201-995 (SMS) unexpectedly stimulates the growth of A431 human epidermoid carcinoma cells in vitro.', 'subject score': 840, 'object score': 1000}, 'PMID:7662508': {'publication date': '1995 Mar', 'sentence': 'This growth promoting effect of PACAP was, however, independent of adenylate cyclase activation but suppressed by pertussis toxin and the somatostatin analog SMS 201-995.', 'subject score': 893, 'object score': 1000}, 'PMID:8262461': {'publication date': '1993 Oct', 'sentence': 'SMS 201-995 has an inhibitory effect on calcitonin secretion and synthesis as well as on the growth of C-cells.', 'subject score': 1000, 'object score': 888}, 'PMID:7872709': {'publication date': '1994 Nov-Dec', 'sentence': 'We believe SMS 201995 stimulates prostatic tumor growth and may sensitize tumor cells to subsequent chemotherapy.', 'subject score': 1000, 'object score': 901}, 'PMID:10861863': {'publication date': '2000 Jun 12', 'sentence': 'They also point to a potential therapeutic benefit of SMS 201995 in the management of human T-cell leukemia.', 'subject score': 1000, 'object score': 1000}, 'PMID:8144862': {'publication date': '1993 Dec', 'sentence': 'Since somatostatin has been reported to have a negative inotropic and chronotropic effect on atria and positive inotropic effect on ventricle, present study was designed to investigate the acute effects of somatostatin analogue SMS 201-995 infusion on the left ventricular function in healthy volunteers.', 'subject score': 864, 'object score': 1000}, 'PMID:11145574': {'publication date': '2001 Jan', 'sentence': 'Somatostatin, or its structural analog SMS 201-995 (SMS), is recognized to exert a growth-inhibitory action in rat pancreas, but the cellular mechanisms are not completely understood.', 'subject score': 854, 'object score': 698}, 'PMID:7692142': {'publication date': '1993 Oct', 'sentence': 'We have previously demonstrated that somatostatin analogues SMS 201-995 and RC-160 inhibit angiogenesis using the chorioallantoic membrane (CAM) of the developing chicken embryo.', 'subject score': 886, 'object score': 1000}, 'PMID:8207509': {'publication date': '1994 Jul', 'sentence': 'The SMS 201-995 improved the symptoms of acromegaly in all patients.', 'subject score': 1000, 'object score': 1000}, 'PMID:7692744': {'publication date': '1993 Sep', 'sentence': 'In the presence of S6, the somatostatin analogue SMS-201-995 (10(-7) M) inhibited gastrin-stimulated histamine release by 95%.', 'subject score': 893, 'object score': 824}, 'PMID:7849444': {'publication date': '1994 Sep', 'sentence': 'These results show that SMS 201-995 increases the level of exogenously infused insulin.', 'subject score': 1000, 'object score': 827}, 'PMID:7907795': {'publication date': '1994 Mar 15', 'sentence': 'A good correlation between the affinities of RC-160 and SMS-201-995 for each receptor subtype and their potencies to inhibit cell proliferation suggests the involvement of these receptors in cell growth regulation.', 'subject score': 1000, 'object score': 1000}, 'PMID:7908405': {'publication date': '1994 Mar', 'sentence': 'Although hSSTR5 displays approximately 75% sequence identity with rat SSTR5, the two receptors display significantly different pharmacological profiles, especially with respect to their binding affinities for the SST analogue SMS 201-995.', 'subject score': 888, 'object score': 759}, 'PMID:7851548': {'publication date': '1995 Feb', 'sentence': 'The combination of 5-FU and SMS 201.995 may be a useful method of improving response to human colorectal cancer therapy.', 'subject score': 1000, 'object score': 861}, 'PMID:7545531': {'publication date': '1994 Nov-Dec', 'sentence': 'Here we further demonstrate that the somatostatin analogue SMS 201-995 as well as the SP receptor antagonist CP 96,345 can effectively decrease the inflammation and lost lymphocyte function seen in the jejunum of T. spiralis-infected mice.', 'subject score': 1000, 'object score': 893}, 'PMID:7910153': {'publication date': '1994 May 15', 'sentence': 'Tumor volumes and weights were reduced significantly to a similar extent by RC-160 and SMS 201-995, administered by daily s.c. injections at a dose of 100 micrograms/day.', 'subject score': 816, 'object score': 1000}, 'PMID:10231556': {'publication date': '1999 May 06', 'sentence': 'The stable SS analogue SMS 201-995 induced a significantly lower inhibition of forskolin-stimulated adenylyl cyclase activity in pancreatic acinar cell membranes from L-Arg-treated rats whereas an increased inhibition was observed in pancreatic acinar membranes from L-NAME-treated rats.', 'subject score': 840, 'object score': 850}, 'PMID:7882976': {'publication date': '1995 Feb 15', 'sentence': 'Thus, it is concluded that the specificity of SMS 201-995 for SSTR2 is mainly defined by these two amino acids in transmembrane domains VI and VII.', 'subject score': 1000, 'object score': 1000}, 'PMID:7733906': {'publication date': '1995 Apr 17', 'sentence': 'SMS 201-995 did not induce detectable apoptosis in unsynchronized cells which remained predominantly in G1 phase.', 'subject score': 1000, 'object score': 861}, 'PMID:8094569': {'publication date': '1993', 'sentence': 'An analog of somatostatin, SMS 201-995 (SMS; Sandostatin), has been shown to have increased potency in the inhibition of hormone secretion in vivo.', 'subject score': 1000, 'object score': 1000}, 'PMID:7612365': {'publication date': '1995 Jun', 'sentence': "In a second part, 10 of these patients received subcutaneously 0.1 mg of SMS 201-995 (a somatostatin's analogue) 30 min before lunch.", 'subject score': 1000, 'object score': 1000}, 'PMID:8124483': {'publication date': '1994 Jan', 'sentence': 'In summary, both bromocriptine and SMS 201-995 at high doses were able to inhibit cell growth of cultured somatotrophic and non-functioning adenomas in vitro.', 'subject score': 1000, 'object score': 1000}, 'PMID:7915736': {'publication date': '1994 May', 'sentence': 'To indirectly evaluate the hypothalamic somatostatin (SS) tone in patients with acromegaly, the effects of pyridostigmine (PD), a cholinesterase inhibitor which can inhibit hypothalamic SS secretion, on TRH-induced TSH secretion and the effects of SMS 201-995 on TSH or GH secretion were studied in acromegalic patients (31-69 yr, n = 10), normal young (21-24 yr, n = 7) and normal old male subjects (62-71 yr, n = 7).', 'subject score': 1000, 'object score': 861}, 'PMID:8340254': {'publication date': '1993 Jun', 'sentence': 'The influence of a somatostatin analogue, SMS 201-995 (SMS), on the growth of an androgen-dependent mouse mammary tumor, Shionogi carcinoma 115 (SC115), was studied.', 'subject score': 1000, 'object score': 1000}, 'PMID:12446025': {'publication date': '2002 Dec', 'sentence': 'The antiproliferative effect of a synthetic octapeptide, somatostatin analogue SMS 201-995 (SMS), and its capacity to bind were evaluated on human peripheral blood lymphocytes (PBL) activated by phytohemoagglutinin (PHA).', 'subject score': 905, 'object score': 893}, 'PMID:12239124': {'publication date': '2002 Oct', 'sentence': 'In rhesus monkey, SOM230 and SMS 201-995 treatment resulted in GH inhibition, with half-maximal inhibitory dose values of 0.5 and 0.4 micro g/kg, respectively, but plasma IGF-I levels were only lowered by SOM230 (-53%).', 'subject score': 916, 'object score': 1000}, 'PMID:17148691': {'publication date': '2007 Mar', 'sentence': 'In addition, SRIF-14, CH-275, SMS 201-995, and L-779,976 decrease IL-8 secretion, and they do not affect IL-8 mRNA expression.', 'subject score': 1000, 'object score': 845}, 'PMID:16162975': {'publication date': '2005 Oct', 'sentence': 'The action of the somatostatin analog SMS-201.995 (SMS) was tested in monotherapy and in combined therapy with the cytotoxic agent 5-fluorouracil (5-FU) on cell cycle kinetics of the human colon cancer cell line WiDr, expressing a mutant p53 (mp53).', 'subject score': 893, 'object score': 888}, 'PMID:19003988': {'publication date': '2009 May 15', 'sentence': 'Structural comparison between the residues of SOM230 and SMS 201-995 provides an explanation for the high binding affinity of SOM230 to four of five somatostatin receptors.', 'subject score': 1000, 'object score': 1000}, 'PMID:23073237': {'publication date': '2012 Dec', 'sentence': 'In addition, 20 male Wistar rats were included to analyze whether the leptin antagonist L39A/D40A/F41A and the SRIF receptor agonist SMS 201-995 modify SRIF signaling and food intake, respectively.', 'subject score': 851, 'object score': 888}, 'PMID:19210422': {'publication date': '1989 Oct 01', 'sentence': 'Thyrotrophin secretion was inhibited by circulating thyroid hormones, dopaminergic agonists and the somatostatin analogue SMS 201-995 but could not be stimulated by thyrotrophin-releasing hormone or further inhibited by exogenous triiodothyronine.', 'subject score': 893, 'object score': 888}, 'PMID:10090448': {'publication date': '1998', 'sentence': 'CONCLUSION: SMS 201-995 significantly inhibits Ach stimulated tear secretion in rats.', 'subject score': 1000, 'object score': 1000}, 'PMID:9467491': {'publication date': '1998 Jan', 'sentence': 'CONCLUSION: SMS 201-995 inhibits penile erection in rats and the systems may serve as an in vivo animal model for further investigation.', 'subject score': 1000, 'object score': 1000}, 'PMID:15756050': {'publication date': '2005', 'sentence': 'Induction of experimental allergic encephalomyelitis in a low-susceptible Albino Oxford rat strain by somatostatin analogue SMS 201-995.', 'subject score': 893, 'object score': 1000}, 'PMID:1395066': {'publication date': '1992 Aug', 'sentence': 'DESIGN: Patients were studied before and after 1 year of bromocriptine or 6 months of SMS 201-995 treatment, for prolactinomas or GH-secreting adenomas, respectively.', 'subject score': 916, 'object score': 1000}, 'PMID:2138476': {'publication date': '1990 Jan', 'sentence': 'CONCLUSIONS: (1) the transplantable PRL-secreting rat pituitary tumor 7315b consists of a functionally homogeneous cell population; (2) growth of this tumor in vivo does not lead to the induction of functionally heterogeneous cell subpopulations within this tumor; (3) the escape of this tumor from the tumor growth-inhibitory effect of SMS 201-995, which has previously been demonstrated in vivo, may not have been the result of clonal selection of somatostatin-unresponsive cells.', 'subject score': 843, 'object score': 1000}, 'PMID:2658575': {'publication date': '1989 Jun', 'sentence': 'CONCLUSION: Our data indicate that the pressor effect of SMS-201-995 is independent of the sympathetic nervous system in patients with multiple system atrophy, but may suppress the adrenergic response to glucose ingestion in patients with progressive autonomic failure.', 'subject score': 872, 'object score': 1000}, 'PMID:2849276': {'publication date': '1988 Dec', 'sentence': 'CONCLUSIONS: Development of resistance to SMS 201-995 both with regard to the clinical effect and to the inhibitory effect on tumour hormone secretion can be expected in some patients with metastatic endocrine pancreatic tumours.', 'subject score': 1000, 'object score': 901}, 'PMID:11980628': {'publication date': '2002 May', 'sentence': 'Whereas SMS 201-995 had a terminal elimination half life of 2 h, this was markedly prolonged in SOM230-treated animals (t(1/2)=23 h).', 'subject score': 840, 'object score': 1000}, 'PMID:19034397': {'publication date': '2008 Dec', 'sentence': 'We found more than a twofold increase of CD4(+)CD25(+) T(reg) cells in the CD4(+) T-cell population and the expression of Foxp3 was up-regulated in the CST treatment groups, compared with control and SMS 201-995 treatment groups.', 'subject score': 875, 'object score': 901}, 'PMID:2404445': {'publication date': '1990 Feb 01', 'sentence': 'STUDY OBJECTIVE: To determine the efficacy of stepwise incremental doses, to compare twice- with thrice-daily administration of the same total daily dosage of the long-acting somatostatin analog SMS 201-995 (octreotide, Sandoz Australia, Sydney, Australia), and to evaluate the risk for cholelithiasis after long-term therapy for acromegaly.', 'subject score': 841, 'object score': 1000}}" |
"biolink:related_to"
-- | -- | -- | --
Here is the problem. Based on my recent fix to issue #1204, I think the next build of KG2 would once again have this edge as biolink:close_match
, which is probably not what we want. I think for SemMedDB xref
edges should be mapped tobiolink:related_to
instead of biolink:close_match
. So I will fix that in semmeddb_tuple_list_json_to_kg_json.py
.
Just to amplify what @dkoslicki and @edeutsch already said above: we appreciate bug reports, especially bugs that pertain to ARAX as seen via the ARS / TRAPI.
This appears to be fixed in KG2.5.2, where the cypher query:
match (n {id: 'NCBIGene:6611'})<-[r]-(m {id: 'UMLS:C0728977'}) return r.predicate, r.predicate_label, r.relation, r.relation_label;
returns
r.predicate | r.predicate_label | r.relation | r.relation_label |
---|---|---|---|
"biolink:related_to" | "related_to" | "SEMMEDDB:xref" | "xref" |
Hate to bother with more issues, but I'm only finding these because of how useful I've found ARAX/ARAX interface 😄 I tried running the following query for finding chemicals connected to SPMSY, which mostly works fine. However, the top result is Octreotide, which doesn't seem to have any relation that I could find to SPMSY, and it's linked by the predicate
biolink:close_match
which is valid biolink, but doesn't make sense in this context. Looking through the PMIDs linked as evidence, they seem to be about somatostatin. Could be a parsing issue in Semmed between SMS (spermine synthase) and somatostatin analogues. Low priority, but I thought I'd give y'all a heads up.https://arax.ncats.io/?r=1281