Closed PaulNSchofield closed 2 years ago
@PaulNSchofield Did you truly intend that Indirect response to ionising radiation be a child of Indirect cellular response to radiation"? Given that not all responses to Ionizing Radiation will be "cellular" this, this would seem to be an incorrect parent class for it.
Well spotted. No that should have been indirect cellular response to ionising radiation. Apologies!
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On 6 Aug 2021, at 01:22, Dan Berrios @.***> wrote:
@PaulNSchofield Did you truly intend that Indirect response to ionising radiation be a child of Indirect cellular response to radiation"? Given that not all responses to Ionizing Radiation will be "cellular" this, this would seem to be an incorrect parent class for it.
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@PaulNSchofield We are wondering if these new terms should be under realizable entity instead of process, where you have put them. If you look at the relations we might put on these objects, it would determine which ones we could use....
From Jack:
I came across this recent paper: Dawood A, Mothersill C, Seymour C. Low dose ionizing radiation and the immune response: What is the role of non-targeted effects? Int J Radiat Biol. 2021 Jul 30;1-60. Review. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/34330196 and it occurred to me to look for "non-targeted effects" and related terms in BioPortal. I was surprised not to find them.
Will close after Paul reviews the additions. Will create another ticket for axioms on these terms.
These have been added, with axiom of"causally downstream of" only radiation for the 2 that are responses to radiation specifically.
Merged into master.
Deprecate: RBO classes: RBO:00000124 and RBO0000123 Reason: These roles now taken by the new GO process classes and they are redundant.
NTR:
Label: Indirect cellular response to stimulus
Child of: http://purl.obolibrary.org/obo/GO_0051716.
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus which acts on another cell and not on the responding cell. The process begins with detection of the stimulus by a cell and ends with a change in state or activity of a different cell.
Example of useage: This could be used to describe a tissue response to immune stimulation, so for example an IL2 response of endothelial cells in response to lymphocytes stimulated by pathogen.
NTR:
Label: Indirect cellular response to radiation
Child of: "Indirect cellular response to stimulus"
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of radiation acting on another cell and not on the responding cell. The process begins with detection of radiation by a cell or cells and ends with a change in state or activity of a different cell or cells.
Example of useage: The most obvious example is the bystander effect ( Carmel Mothersill, Andrej Rusin, Cristian Fernandez-Palomo & Colin Seymour (2018) History of bystander effects research 1905-present; what is in a name?, International Journal of Radiation Biology, 94:8, 696-707, DOI: 10.1080/09553002.2017.1398436) where a naive cell behaves as if it has been irradiated because of its communication with an irradiated cell. It may also be used to describe the abscopal effect. Note that abscopal effects have been noted for ionising and non-ionising ( RF) radiation, eg. Löffler MW. et al. . A Non-interventional Clinical Trial Assessing Immune Responses After Radiofrequency Ablation of Liver Metastases From Colorectal Cancer. Front Immunol. 2019 Nov 19;10:2526. doi: 10.3389/fimmu.2019.02526. PMID: 31803175; PMCID: PMC6877671..
NTR: Indirect response to ionising radiation
Child of: "Indirect cellular response to radiation"
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to ionising radiation which acts on another cell and not on the responding cell. The process begins with detection of the ionising radiation by one cell or cells and ends with a change in state or activity of a different cell or cells.
Example of useage: Directly describes the bystander effect (Carmel Mothersill, Andrej Rusin, Cristian Fernandez-Palomo & Colin Seymour (2018) History of bystander effects research 1905-present; what is in a name?, International Journal of Radiation Biology, 94:8, 696-707, DOI: 10.1080/09553002.2017.1398436) but can alo sbe used to describe phenomena related to the abscopal effect, manifest in whole organisms where irradiation of one part of the organism causes changes in another un-irradiated component.
Move : Bystander effect: http://purl.obolibrary.org/obo/RBO_010003 to be a child of "Indirect response to ionising radiation" the first new term requested here..
The logic here is that the bystander effect involves at least two cells, at least one of which, the responder is NOT irradiated. However the effect does not occur if no cells are irradiated, so indirectly the bystander effect is necessarily a consequence of at least one cell being irradiated.