epigenetic inheritance paper hunt

[meganewing]

Howdy all! I’m looking for a paper on epigenetic inheritance. ideally with an experimental setup of something like F0 (control/ambient conditions) F1 (various treatments) F2( control/ambient conditions) to look at how well retained epigenetic changes are for offspring of parents who faced the altered environment, but the offspring themselves haven’t faced the altered environment.

I’ve been searching but haven’t quite yet found what i’m looking for. I feel like I remember someone doing something similar with OA in oysters across generations but can’t remember who.

Does anyone have any paper recommendations?

[sr320]

In oysters we have unpublished "CEABIGR" data... Also french have at least two publications looking at pesticide exposure... https://pubmed.ncbi.nlm.nih.gov/38217500/ - and Rondon et al (which is certainly cited within...)

More broadly, examples of epigenetic inheritance in invertebrates encompass various mechanisms and organisms. For instance, in C. elegans, dsRNA-mediated gene silencing (RNAi) can be inherited for more than five generations, demonstrating a striking example of epigenetic inheritance (Buckley et al., 2012). Additionally, in honey bees, there is evidence of the intergenerational transfer of DNA methylation marks, indicating transgenerational epigenetic inheritance in invertebrates (Yagound et al., 2020). Furthermore, the review by Lim & Brunet (2013) surveys recent examples of epigenetic inheritance induced by genetic and environmental perturbations in animals, shedding light on the broad scope of epigenetic inheritance in invertebrates. Moreover, the study by Harris et al. (2019) suggests that transgenerational epigenetic inheritance of DNA methylation may be a common feature of invertebrates.

Publications consulted. Buckley, B., Burkhart, K., Gu, S., Spracklin, G., Kershner, A., Fritz, H., … & Kennedy, S. (2012). A nuclear argonaute promotes multigenerational epigenetic inheritance and germline immortality. Nature, 489(7416), 447-451. https://doi.org/10.1038/nature11352 Chille, E., Strand, E., Neder, M., Schmidt, V., Sherman, M., Mass, T., … & Putnam, H. (2021). Developmental series of gene expression clarifies maternal mrna provisioning and maternal-to-zygotic transition in a reef-building coral. BMC Genomics, 22(1). https://doi.org/10.1186/s12864-021-08114-y Gerdol, M., Gomez‐Chiarri, M., Castillo, M., Figueras, A., Fiorito, G., Moreira, R., … & Vasta, G. (2018). Immunity in molluscs: recognition and effector mechanisms, with a focus on bivalvia., 225-341. https://doi.org/10.1007/978-3-319-76768-0_11 Harris, K., Lloyd, J., Domb, K., Zilberman, D., & Zemach, A. (2019). Dna methylation is maintained with high fidelity in the honey bee germline and exhibits global non-functional fluctuations during somatic development. Epigenetics & Chromatin, 12(1). https://doi.org/10.1186/s13072-019-0307-4 Head, J. (2014). Patterns of dna methylation in animals: an ecotoxicological perspective. Integrative and Comparative Biology, 54(1), 77-86. https://doi.org/10.1093/icb/icu025 Hinzmann, M., Lopes‐Lima, M., Boboş, I., Ferreira, J., Domingues, B., & Machado, J. (2014). Morphological and chemical characterization of mineral concretions in the freshwater bivalve anodonta cygnea (unionidae). Journal of Morphology, 276(1), 65-76. https://doi.org/10.1002/jmor.20320 Lim, J. and Brunet, A. (2013). Bridging the transgenerational gap with epigenetic memory. Trends in Genetics, 29(3), 176-186. https://doi.org/10.1016/j.tig.2012.12.008 Putnam, H., Trigg, S., White, S., Spencer, L., Vadopalas, B., Natarajan, A., … & Roberts, S. (2022). Dynamic dna methylation contributes to carryover effects and beneficial acclimatization in geoduck clams.. https://doi.org/10.1101/2022.06.24.497506 Yagound, B., Remnant, E., Buchmann, G., & Oldroyd, B. (2020). Intergenerational transfer of dna methylation marks in the honey bee. Proceedings of the National Academy of Sciences, 117(51), 32519-32527. https://doi.org/10.1073/pnas.2017094117

[sr320]

There is also https://www.sciencedirect.com/science/article/pii/S037811191930825X

Epigenetic inheritance and intergenerational effects in mollusks

Recent insights in evolutionary biology have shed light on epigenetic variation that interacts with genetic variation to convey heritable information. An important characteristic of epigenetic changes is that they can be produced in response to environmental cues and passed on to later generations, potentially facilitating later genetic adaptation. While our understanding of epigenetic mechanisms in vertebrates is rapidly growing, our knowledge about invertebrates remains lower, or is restricted to model organisms. Mollusks in particular, are a large group of invertebrates, with several species important for ecosystem function, human economy and health. In this review, we attempt to summarize the literature on epigenetic and intergenerational studies in mollusk species, with potential importance for adaptive evolution. Our review highlights that two molecular bearers of epigenetic information, DNA methylation and histone modifications, are key features for development in mollusk species, and both are sensitive to environmental conditions to which developing individuals are exposed. Further, although studies are still scarce, various environmental factors (e.g. predator cues, chemicals, parasites) can induce intergenerational effects on the phenotype (life-history traits, morphology, behaviour) of several mollusk taxa. More work is needed to better understand whether environmentally-induced changes in DNA methylation and histone modifications have phenotypic impacts, whether they can be inherited through generations and their role in intergenerational effects on phenotype. Such work may bring insights into the potential role of epigenetic in adaptation and evolution in mollusks.

[meganewing]

thank you!