Hello there,
My question is how to tell from the results whether a mutation is clonal or not?
At first I thought mutations in cluster with the biggest CCF should be classified into clonal. Howerver I found later that in some samples the biggest CCF was smaller than 0.5. So I'm not sure how to classify these mutations(in cluster with the biggest CCF but CCF is not big enough).
In terms of input setting,in addition to fields that are required, I also provided purity. I run the script using beta-binomial model.
A specific sample(this sample has one cluster and has the biggest CCF 0.3333) like this:
Hello there, My question is how to tell from the results whether a mutation is clonal or not? At first I thought mutations in cluster with the biggest CCF should be classified into clonal. Howerver I found later that in some samples the biggest CCF was smaller than 0.5. So I'm not sure how to classify these mutations(in cluster with the biggest CCF but CCF is not big enough). In terms of input setting,in addition to fields that are required, I also provided purity. I run the script using beta-binomial model. A specific sample(this sample has one cluster and has the biggest CCF 0.3333) like this: