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Russel88 / CRISPRCasTyper

CCTyper: Automatic detection and subtyping of CRISPR-Cas operons
https://typer.crispr.dk
MIT License
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Cas6 in red in visualization? #20

Closed mhyleung closed 2 years ago

mhyleung commented 2 years ago

Dear all

Why is it that the Cas6 proteins are coloured in red in the visualization, as opposed to the other enzymes of either adaptation (blue) or interference (red) modules? Is there something functionally unique about Cas6 to be coloured separately?

Thanks

Marcus

Russel88 commented 2 years ago

Hi Marcus,

We chose to color Cas6 differently, as it is the enzyme responsible for processing pre-crRNA into mature, functional crRNA in Class 1 systems - sometimes forming part of the interference complex itself and othertimes not. There are of course exceptions, for example with I-C where Cas5d is responsible for crRNA maturation.

https://www.nature.com/articles/nrmicro3569/figures/1