Open XiaPoppy opened 1 year ago
Hi Danyang, Short answer: I think people tend to believe that the batch effects are gene-specific. For example, see Combat-seq. You can check more literature or real data and decide whether it is reasonable (keep me posted if you find a conclusion, thanks!)
Best, Dongyuan
Hi Dongyuan,
in case I have 3 batches in total and I call the mean of the normalisation distribution 'strength':
Then I can separate all the 3 batches.
I am thinking about one thing now: Why don't we sample one value for a batch, and apply this value for all the features(genes) in this batch?
i.e.
Looking forward to your reply!
Best, Danyang