Closed annagree closed 5 years ago
Here is the content for the modal, styling should be similar to exiting "Summary of Evidence" modal.
Nominated: Indicates whether this gene has been nominated by the AMP-AD consortium as a nascent target for AD treatment.
Brain eQTL: Significant expression Quantitative Trait Locus (eQTL) based on AMP-AD consortium unpublished work.
Genetic Association: Significant genetic association with Late Onset AD (LOAD) based on the International Genomics of Alzheimer's Project (IGAP) genome-wide association study.
Druggability: Targets have been scored for likely suitability for small-molecule drugs (SM ligandability) in a multi-step process. In brief, targets are placed into buckets that are ordered according to preference for small-molecule (SM) drug development, with smaller bucket numbers being generally accepted as easier or more likely to result in successful drug development than larger numbered buckets.
Pharos Class: This indicates the “Development Level” of the selected target as classified by Pharos Targets are assigned a classification related to the amount of knowledge about the target, where Tclin > Tchem > Tbio > Tdark. Targets categorized as Tclin have approved drugs with known mechanisms of action, whereas targets categorized as Tdark have virtually nothing is known about them.
Updated the above to fix a few typos.
closing- duplicate
See placement of new modal per Figma: