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Sage-Bionetworks / Agora

MIT License
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need info modal for "Similar Genes" page #465

Closed annagree closed 5 years ago

annagree commented 5 years ago

See placement of new modal per Figma:

screen shot 2018-10-23 at 10 46 26 am
annagree commented 5 years ago

Here is the content for the modal, styling should be similar to exiting "Summary of Evidence" modal.

Nominated: Indicates whether this gene has been nominated by the AMP-AD consortium as a nascent target for AD treatment.

Brain eQTL: Significant expression Quantitative Trait Locus (eQTL) based on AMP-AD consortium unpublished work.

Genetic Association: Significant genetic association with Late Onset AD (LOAD) based on the International Genomics of Alzheimer's Project (IGAP) genome-wide association study.

Druggability: Targets have been scored for likely suitability for small-molecule drugs (SM ligandability) in a multi-step process. In brief, targets are placed into buckets that are ordered according to preference for small-molecule (SM) drug development, with smaller bucket numbers being generally accepted as easier or more likely to result in successful drug development than larger numbered buckets.

Pharos Class: This indicates the “Development Level” of the selected target as classified by Pharos Targets are assigned a classification related to the amount of knowledge about the target, where Tclin > Tchem > Tbio > Tdark. Targets categorized as Tclin have approved drugs with known mechanisms of action, whereas targets categorized as Tdark have virtually nothing is known about them.

annagree commented 5 years ago

Updated the above to fix a few typos.

annagree commented 5 years ago

closing- duplicate