Meta-analysis component

Sage-Bionetworks / sageseqr

A workflow for exploring and analyzing RNA-seq data.

https://sage-bionetworks.github.io/sageseqr/

MIT License

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Open kelshmo opened 4 years ago

kelshmo commented 4 years ago

How will this fit into the overall workflow? I think a separate and distinct plan is best to accommodate the output from several cohorts.

kelshmo commented 3 years ago

The meta-analysis will:

Accept residual expression and covariate matrices
Compute n, mean and sd per gene per x condition (or per x and y,z conditions). x is the outcome variable. <what are the implications of this being a list?>
Meta-analysis of continuous outcome, experimental v. control, computed on every gene. One effect per gene, across all conditions.