Thanks for the wonderful tool!
This issue might only be about biology, not technology.
In the file new_ligand_receptor_TFs.txt, there are 3 columns: Ligand_Symbol, Receptor_Symbol and TF_Symbol.
In each row, is TF_Symbol activated by only Receptor_Symbol activation or combination of both Ligand_Symbol and Receptor_Symbol?
For example, in line 3: CCL26--CCR1--FOXO3, is FOXO3 activated by any ligand binding to CCR1, or activated by only CCL26 binding to CCR1 strictly?
Thanks for any help!
Thanks for the wonderful tool! This issue might only be about biology, not technology. In the file new_ligand_receptor_TFs.txt, there are 3 columns: Ligand_Symbol, Receptor_Symbol and TF_Symbol. In each row, is TF_Symbol activated by only Receptor_Symbol activation or combination of both Ligand_Symbol and Receptor_Symbol? For example, in line 3: CCL26--CCR1--FOXO3, is FOXO3 activated by any ligand binding to CCR1, or activated by only CCL26 binding to CCR1 strictly? Thanks for any help!