The IMPACT rating is a separate rating given for compatibility with other variant annotation tools (e.g. snpEff). High impact variant consequence. The variant is assumed to have high (disruptive) impact in the protein, probably causing protein truncation, loss of function or triggering nonsense mediated decay. the IMPACT column is a subjective classification of the severity of the variant consequence, based on agreement with SNPEff. You can find detailed information on all of our consequences and the associated impact values here: impact
The IMPACT rating is a separate rating given for compatibility with other variant annotation tools (e.g. snpEff). High impact variant consequence. The variant is assumed to have high (disruptive) impact in the protein, probably causing protein truncation, loss of function or triggering nonsense mediated decay. the IMPACT column is a subjective classification of the severity of the variant consequence, based on agreement with SNPEff. You can find detailed information on all of our consequences and the associated impact values here: impact