🌲 An easy-to-use and scalable toolkit for genomic alteration signature (a.k.a. mutational signature) analysis and visualization in R https://shixiangwang.github.io/sigminer/reference/index.html
I am trying to apply sig_extract but failed with the following error message. The interesting thing is I can apply extractSignatures() successfully. What I need is to get the absolute mutational signatures rather than just relative proportions, but I think results from extractSignatures() cannot really provide this, right? Thanks a lot!
Hi Shixiang,
I am trying to apply sig_extract but failed with the following error message. The interesting thing is I can apply extractSignatures() successfully. What I need is to get the absolute mutational signatures rather than just relative proportions, but I think results from extractSignatures() cannot really provide this, right? Thanks a lot!
mt_sig <- sig_extract(mt_tally$nmf_matrix, n_sig = 3, nrun = 5, pConstant = 0.1 )
Error: NMF::nmf - 5/5 fit(s) threw an error.
Error(s) thrown: