Let's say I have all 6 set pieces for T21, and have an item in each slot which is around the same power level as each set piece without the bonus. Currently, that is 2^6 (64) combinations, but in practice only those combinations with the 4pc bonus are going to be viable (i.e. 6C4=15). Eliminating those profiles which don't have the T21 bonus would reduce the required simulations by a factor of 4.
While this is an option that can be selected in simpermut, it doesn't seem to carry over to autosimc, and there's no way to select it as far as I can see.
Let's say I have all 6 set pieces for T21, and have an item in each slot which is around the same power level as each set piece without the bonus. Currently, that is 2^6 (64) combinations, but in practice only those combinations with the 4pc bonus are going to be viable (i.e. 6C4=15). Eliminating those profiles which don't have the T21 bonus would reduce the required simulations by a factor of 4.
While this is an option that can be selected in simpermut, it doesn't seem to carry over to autosimc, and there's no way to select it as far as I can see.