Can't run mouse_imm_ref command, SSL issue

[comrade1809]

Hi, I'm an IT rep for our company and one of our researchers is trying to do the following, but is unable to:

> library(celldex)
> mouse_imm_ref <- celldex::ImmGenData()
Error in value[[3L]](cond) : failed to connect
  reason: SSL certificate problem: unable to get local issuer certificate
  Consider rerunning with 'localHub=TRUE'

I'm not too knowledgeable in what R does or how to use it, so I'm trying to troubleshoot this the best I can. Can you please advise as to why this might be happening? If it's a network issue, where does that command reach for data so we can see if the issue is on our end? This is running within R version 4.1.0.

Thank you,

Aleksey

[LTLA]

Hm. That's pretty deep in the stack, and nothing comes to mind on my end.

I'm guessing it's a curl error (from the package of the same name). Maybe jeroen/curl#122 might be relevant.

Further guessing that the failing endpoint is at https://bioconductor.org/config.yaml, based on the probable traceback():

• ExperimentHub calls down to AnnotationHub:::.Hub at https://github.com/Bioconductor/AnnotationHub/blob/09fb82f71525dc72844bd82da3ea07f70b99ad42/R/Hub-class.R#L31-L37
• This in turn calls AnnotationHub:::.biocVersionDate that does a GET for the BioC URL mentioned above.