What should the model output be?

[SirPurrcival]

Spikes, membrane potential or current? Data is in CSD. What is the appropriate comparison? Write function that outputs the correct measure

[krisevers]

methods used by Lowet et al. (2017) CSD estimation >>> https://doi.org/10.1016/0165-0270(88)90056-8 Layer assignment >>> https://doi.org/10.1016/0042-6989(91)90040-C Interlaminar coherence >>> https://doi.org/10.3389/fnsys.2010.00031 "Coherence is a measure of similarity in the temporal structure of two signals that quantifies the extent to which two signals are linearly related"

[krisevers]

another note on current source density (CSD): CSD quantifies whether an electrode is located near a current sink or a current source. If it is a current sink, i.e. a lot of current is flowing towards this location/electrode, then there are signals being send towards this area, i.e. it is neurally active. If it is a current source, a lot of current is flowing away from this location/electrode, i.e. it is neurally inactive. CSD can thus be seen as a measure of the flow of neural activity and therefore it makes sense to take the derivative over time of the LFP, as it is close to the change in LFP over time.

[SirPurrcival]

Original data has 16 electrode contact points along the electrode

• Which one corresponds to which layer? (how many are we even using?)
• Record from V_m
• assign depth "distance" to layers for the conversion function

[SirPurrcival]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682791/ https://elephant.readthedocs.io/en/v0.6.2/reference/current_source_density.html These might be usable