Starlitnightly / omicverse

A python library for multi omics included bulk, single cell and spatial RNA-seq analysis.
https://starlitnightly.github.io/omicverse/
GNU General Public License v3.0
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Inquiry about Integrating Bulk RNA-seq Data with Single-Cell Data in OmicVerse #186

Closed md26meng closed 1 month ago

md26meng commented 1 month ago

Dear Author,

I am currently working with bulk RNA-seq data from cells after treatment, alongside single-cell RNA-seq data from a publicly available dataset. I am looking for a method to integrate my bulk RNA-seq results with specific cell clusters in the single-cell data.

I have explored the bulk2single function in OmicVerse, but I am curious if there is a way to utilize the bulk RNA-seq data to refine or enhance the analysis of specific cell populations in the single-cell dataset.

Could you kindly advise if there is an existing feature or approach within OmicVerse that would allow for such an integration? Alternatively, would it be feasible to develop a custom method to achieve this?

Thank you very much for your time and help. I look forward to your guidance!

Best regards