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StructuralGenomicsConsortium / CNP17-DENVRdrp-EnamineCovalent

An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on exploring the Enamine covalent library. Use the link below to learn about other READDI-AViDD projects.
https://tinyurl.com/READDIAC
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Join this project! #1

Open RebeckaIsaksson opened 2 months ago

RebeckaIsaksson commented 2 months ago

Hi,

If you've made it this far you are clearly keen on getting involved in this project, and we are glad for your interest!

In the Wiki you can learn more about what has been done in the project; the sidebar on the right holds pages with more details on the various explorations.

We have identified these sulfonyl-fluoride compounds as being favored in binding DENV2 over other viruses we have tested.

image

We want to find collaborators that can join us in exploring these covalent ligands - do you have any sulfonyl-fluoride compounds, preferably bound to aromatic heterocycles? Get in touch with us, and we will test them.

rahmanszsaleem commented 2 months ago

The call-out has been posted at X and LinkedIn

GhayoorAbbasLums commented 2 months ago

Dear Rebecka We have several arylsulfonyl fluorides and would like to contribute to this project

RebeckaIsaksson commented 2 months ago

@GhayoorAbbasLums Thank you for your interest! It would be great if you could share some of the structures that you have? Where are you based?

rahmanszsaleem commented 2 months ago

I was looking at the literature and saw the following recently published papers reporting synthesis of sulfonyl fluorides:

https://pubs.acs.org/doi/10.1021/acs.joc.2c02630

https://pubs.rsc.org/en/content/articlehtml/2022/cc/d2cc05781f

https://pubs.rsc.org/en/content/articlelanding/2023/qo/d2qo01810a/unauth

https://doi.org/10.1016/j.tet.2023.133364

https://doi.org/10.1080/00397911.2023.2246603

It would be wonderful to reach out to these authors and explore the possibility of working together and testing the new sulfonyl fluorides that they have made.

RebeckaIsaksson commented 1 month ago

@GhayoorAbbasLums Thank you for your interest! It would be great if you could share some of the structures that you have? Where are you based?

Information provided via email: image

GhayoorAbbasLums commented 1 month ago

Dear Dr. Rebecka We are based in Lahore University of Management Sciences (LUMS) that is located in Lahore Pakistan. I have also been in touch with you through my UMS email id i.e. @.*** and have shared list with you through Lums email ID. Thank you very much.

Regards,

Ghayoor Abbas

From: Rebecka Isaksson @.> Sent: Monday, May 20, 2024 2:34 PM To: StructuralGenomicsConsortium/CNP17-DENVRdrp-EnamineCovalent @.> Cc: GhayoorAbbasLums @.>; Mention @.> Subject: Re: [StructuralGenomicsConsortium/CNP17-DENVRdrp-EnamineCovalent] Join this project! (Issue #1)

@GhayoorAbbasLumshttps://github.com/GhayoorAbbasLums Thank you for your interest! It would be great if you could share some of the structures that you have? Where are you based?

Information provided via email: image.png (view on web)https://github.com/StructuralGenomicsConsortium/CNP17-DENVRdrp-EnamineCovalent/assets/135242493/ca2e2bd0-b3cb-4337-ba88-24f3e1f07a05

— Reply to this email directly, view it on GitHubhttps://github.com/StructuralGenomicsConsortium/CNP17-DENVRdrp-EnamineCovalent/issues/1#issuecomment-2120061312, or unsubscribehttps://github.com/notifications/unsubscribe-auth/BIGVIHJFHQAVWDD6TSIR5STZDG7SLAVCNFSM6AAAAABHAE34CGVHI2DSMVQWIX3LMV43OSLTON2WKQ3PNVWWK3TUHMZDCMRQGA3DCMZRGI. You are receiving this because you were mentioned.Message ID: @.***>

RebeckaIsaksson commented 1 month ago

The first contribution to this project is on it's way to UCL!