Gram-scale synthesis if starting material for RA-3301 - Githubissues

StructuralGenomicsConsortium / CNP18-DENVRdrp-VirtualScreen

An SGC Chemical Networks Project devoted to the DENV Rdrp, focusing specifically on the results from a virtual screening campaign of the Enamine REAL space to identify hits. Use the link below to learn about other READDI-AViDD projects.

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Gram-scale synthesis if starting material for RA-3301 #4

Open RebeckaIsaksson opened 1 month ago

RebeckaIsaksson commented 1 month ago

In April 2024 at our CRO partner Piramal was asked to synthesize gram-scale synthesis of the head-group of RA-3301 needed to explore the SAR (nb. this fragment has also been tested as RA-20641 and shown activity). The below comments list the work process to generate:

RebeckaIsaksson commented 1 month ago

First report May 02 2024

20240502_Piramal update

RebeckaIsaksson commented 1 month ago

Second report May 14 2024

RebeckaIsaksson commented 1 month ago

Third report May 21 2024

RebeckaIsaksson commented 1 month ago

Fourth report June 04 2024

Material on it's way to UCL