Open-Source Coronavirus Monthly Update Meeting #6: 17:00-18:00 BST, Monday 14th November 2022

TomkUCL commented 1 year ago

Date: Mon Nov 14th 2022 Time: 5pm UK time (other times)
Place: https://ucl.zoom.us/j/97172937586 Recording: Apologies - forgot to record this one... Previous Meeting: issue #29
Who can come?: Anyone. No need to say anything unless you'd like to. If you'd like to contribute, please join Github.

Attending: @mattodd @TomkUCL @SumeraMalik123 @toluene44 @ahsgc @tmw20653 @jamesday100 @kipUNC

Apologies: none

Decks: Please @StructuralGenomicsConsortium/cnp4-nsp13 remember that if you share slides/info, to drag and drop those into a comment on this page, below. Very easy and saves @mattodd having to pester you.

@StructuralGenomicsConsortium/cnp4-nsp13 rough agenda, sorry for lateness:

Agenda:

1) Status and planning for the SPR assay #25

@TomkUCL to update. In meeting: Traces obtained for control compound ("PUG") look similar to those in lit, though issue of using correct buffers needs to be sorted out. Next runs: can try the non-hydrolyzable analog of ATP, then the Enamine test compounds. @SumeraMalik123 updated that she had completed her S{R screen of these compounds and found about 3 hits. Compounds also screened vs MERS Nsp13. Compounds had been screened in ATPase assay, with some activity. @ahsgc to summarise these hits (data on Signals) and provide thoughts on SAR, since we can order compounds possessing similar structures.

[ ] @ahsgc to post structures of actives and any ideas on SAR.
[ ] @TomkUCL to complete screen of these compounds by SPR in UCL

It would be useful to try these compounds on the Creoptix Wave.

[ ] @mattodd and @TomkUCL to reach out to Domainex to ask for quote for establishing Wave screening protocol, ideally in comparison with SPR.

2) Molecule Procurement.

Where we are up to with the set of molecules predicted by Kostya to be binders - the comparison between the Enamine docking set and the generative set. Including updates on chemistry from Tom and Anwar (pyramal) - what's already come in, what's coming in, what's scheduled and whether any molecules are currently not scheduled for delivery (and might need replacing). In meeting:

[ ] @TomkUCL and @ahsgc to collaborate on the list of compounds from the Enamine and Generative sets that have already come in, that are scheduled to come in from Enamine/Pyramal and which are scheduled for synthesis in READDI. Are there any missing that need to be procured? We need enough members of each set to make a meaningful comparison between Enamine and Generative sets.

3) Which compounds should be sent to Joe Newman at Oxford/Diamond for a crystal soak?

Offer of a crystal soak from Joe Newman. Which compounds to send? In meeting: Certainly the compounds identified in 1) above. Also any other hits found by @TomkUCL in SPR screen. Plus any other compounds identified before cut off in 1-2 weeks time. Maybe PUG compound? Amount needed: If in DMSO at e.g. 50-100 mM then liquids preferred to save time with dissolving (10 ul is enough), otherwise around 1-5 mg of solid is more than enough. Will do 20 at a time.

[ ] @mattodd to liaise with Joe to establish best dates, when data can be acquired (i.e. when there is beamtime) and whether our 20 mM DMSO stocks are OK, in terms of the amount of DMSO.

(Hopefully we can simply send from UCL and not have to reorder compounds).

4) What's needed next in the helicase review?

[ ] @TomkUCL and @ahsgc to work to combine Google docs - there are currently too many.
[ ] @TomkUCL to complete 2-3 paragraphs on Nsp13 mechanism, and the animation for the paper.
[ ] @tmw20653 to set up Google Drive where we can collect documents together
[ ] Matthieu Schapira is working on a section about helihub, and a comparison of human and viral helicases.
[ ] @ahsgc to work with other students at UNC (Eugene and Holly Joe?) to complete the list of known helicase inhiitors.
[ ] @tmw20653 to write some introductory remarks

5) AOB

[ ] For any future compound design/purchase, @kipUNC to filter based on predicted solubility (any other parameters?)
[ ] There is an AViDD open talk this Wed (Nov 16th 2022) where we will discuss the helicase work: https://meetmsk.zoom.us/webinar/register/WN_oH8bnuyvRm-MP0V4NhfE-Q

@jamesday100 is thanked for his ongoing role as Pharma Champion for this project.

Next Meeting Dec 12th 5pm UK time at https://ucl.zoom.us/j/97172937586

L'esprit de l'escalier If you'd like to follow up after the meeting, please comment below. You can also email, but please be clear if anything in the email should not be public domain - the default is open.

Evert-Homan commented 1 year ago

Hi Tom,

Thanks for the invite but I need to refrain, I have too many projects on my plate as it is.

BW/Evert

From: Tom Knight @.> Sent: Tuesday, 15 November 2022 12:16 To: StructuralGenomicsConsortium/CNP4-Nsp13-C-terminus-B @.> Cc: Evert Homan @.>; Team mention @.> Subject: [StructuralGenomicsConsortium/CNP4-Nsp13-C-terminus-B] Open-Source Coronavirus Monthly Update Meeting #6: 17:00-18:00 BST, Monday 14th November 2022 (Issue #30)

Date: Mon Nov 14th 2022 Time: 5pm UK time (other timeshttps://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.timeanddate.com%2Fworldclock%2Fmeetingdetails.html%3Fyear%3D2022%26month%3D11%26day%3D14%26hour%3D17%26min%3D0%26sec%3D0%26p1%3D43%26p2%3D136%26p3%3D37%26p4%3D771%26p5%3D235%26p6%3D152%26p7%3D770%26p8%3D250%26p9%3D196%26p10%3D240&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877123141%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=NUIkAchUF3YVQhbzkIbiM1Tdwao%2FSUOG8lrGrSqntts%3D&reserved=0) Place: https://ucl.zoom.us/j/97172937586 https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fucl.zoom.us%2Fj%2F97172937586&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877123141%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=4GjpaHvTEytYJr%2Fn4t4pQDeCwuqTQR45ag9b5LLjDJI%3D&reserved=0 Recording: Apologies - forgot to record this one... Previous Meeting: issue #29https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2FStructuralGenomicsConsortium%2FCNP4-Nsp13-C-terminus-B%2Fissues%2F29&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877123141%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=R430fZtJolUZaAm5j6N%2BEnYulzdCAZYDMMGsWMRSjkc%3D&reserved=0 Who can come?: Anyone. No need to say anything unless you'd like to. If you'd like to contribute, please join Github.

Apologies: none

Decks: Please @StructuralGenomicsConsortium/cnp6-abhd2https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Forgs%2FStructuralGenomicsConsortium%2Fteams%2Fcnp6-abhd2&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877123141%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=GJC0RD6p9xo828PpnzePN9yU3gCKcwlC8XjvSAkUiM4%3D&reserved=0 remember that if you share slides/info, to drag and drop those into a comment on this page, below. Very easy and saves @mattoddhttps://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Fmattodd&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877123141%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=LZ6wm5PXlilteOkLh4QHH0rZCf2sFFXUUWIZu2Ls0KA%3D&reserved=0 having to pester you.

@StructuralGenomicsConsortium/cnp4-nsp13https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Forgs%2FStructuralGenomicsConsortium%2Fteams%2Fcnp4-nsp13&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877123141%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=vWYztTeI4Jzgs1qfEkhFPwqlAZAOdX4ZjXXC6LgCXEw%3D&reserved=0 rough agenda, sorry for lateness:

Agenda: 1) Status and planning for the SPR assay #25https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2FStructuralGenomicsConsortium%2FCNP4-Nsp13-C-terminus-B%2Fissues%2F25&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877123141%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=oYkbJOYO9KVyvQcLmXqP1EYSj2llL%2Fljj0%2FxaTawD8o%3D&reserved=0

@TomkUCLhttps://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2FTomkUCL&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877123141%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=CzSWZvn1qrclhPCFOmFJTED%2Bvw43vjW9IHEar7vKKtg%3D&reserved=0 to update. In meeting: Traces obtained for control compound ("PUG") look similar to those in lit, though issue of using correct buffers needs to be sorted out. Next runs: can try the non-hydrolyzable analog of ATP, then the Enamine test compounds. @SumeraMalik123https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2FSumeraMalik123&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877123141%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=18EKAXLR7RtKs3GH4nH9HC6HRhm%2Bugch%2BjoutKdIQss%3D&reserved=0 updated that she had completed her S{R screen of these compounds and found about 3 hits. Compounds also screened vs MERS Nsp13. Compounds had been screened in ATPase assay, with some activity. @ahsgchttps://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Fahsgc&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877279344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=7T194I5NBzgJyAcA%2Bra3VZQGm1OJypoh7DYzPYCjutc%3D&reserved=0 to summarise these hits (data on Signals) and provide thoughts on SAR, since we can order compounds possessing similar structures.

It would be useful to try these compounds on the Creoptix Wave.

[ ] @mattoddhttps://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Fmattodd&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877279344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=k08cJPsUfv8H1U7%2F8b8WEonTrR3gyYY9gPpJ5ALiw9k%3D&reserved=0 and @TomkUCLhttps://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2FTomkUCL&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877279344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=1KbqRDoVLWM2chx1B2vLN3kW%2Bhzq%2BOt7nMoegwM0css%3D&reserved=0 to reach out to Domainex to ask for quote for establishing Wave screening protocol, ideally in comparison with SPR.

2) Molecule Procurement.

Where we are up to with the set of molecules predicted by Kostya to be binders - the comparison between the Enamine docking set and the generative set. Including updates on chemistry from Tom and Anwar (pyramal) - what's already come in, what's coming in, what's scheduled and whether any molecules are currently not scheduled for delivery (and might need replacing).

[ ] @TomkUCLhttps://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2FTomkUCL&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877279344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=1KbqRDoVLWM2chx1B2vLN3kW%2Bhzq%2BOt7nMoegwM0css%3D&reserved=0 and @ahsgchttps://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Fahsgc&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877279344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=7T194I5NBzgJyAcA%2Bra3VZQGm1OJypoh7DYzPYCjutc%3D&reserved=0 to collaborate on the list of compounds from the Enamine and Generative sets that have already come in, that are scheduled to come in from Enamine/Pyramal and which are scheduled for synthesis in READDI. Are there any missing that need to be procured? We need enough members of each set to make a meaningful comparison between Enamine and Generative sets.

3) Which compounds should be sent to Joe Newman at Oxford/Diamond for a crystal soak?

Offer of a crystal soak from Joe Newman. Which compounds to send? In meeting: Certainly the compounds identified in 1) above. Also any other hits found by @TomkUCLhttps://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2FTomkUCL&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877279344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=1KbqRDoVLWM2chx1B2vLN3kW%2Bhzq%2BOt7nMoegwM0css%3D&reserved=0 in SPR screen. Plus any other compounds identified before cut off in 1-2 weeks time. Maybe PUG compound? Amount needed: If in DMSO at e.g. 50-100 mM then liquids preferred to save time with dissolving (10 ul is enough), otherwise around 1-5 mg of solid is more than enough. Will do 20 at a time.

[ ] @mattoddhttps://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Fmattodd&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877279344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=k08cJPsUfv8H1U7%2F8b8WEonTrR3gyYY9gPpJ5ALiw9k%3D&reserved=0 to liaise with Joe to establish best dates, when data can be acquired (i.e. when there is beamtime) and whether our 20 mM DMSO stocks are OK, in terms of the amount of DMSO.

(Hopefully we can simply send from UCL and not have to reorder compounds).

4) What's needed next in the helicase review?

[ ] @TomkUCLhttps://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2FTomkUCL&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877279344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=1KbqRDoVLWM2chx1B2vLN3kW%2Bhzq%2BOt7nMoegwM0css%3D&reserved=0 and @ahsgchttps://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Fahsgc&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877279344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=7T194I5NBzgJyAcA%2Bra3VZQGm1OJypoh7DYzPYCjutc%3D&reserved=0 to work to combine Google docs - there are currently too many.
[ ] @TomkUCLhttps://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2FTomkUCL&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877279344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=1KbqRDoVLWM2chx1B2vLN3kW%2Bhzq%2BOt7nMoegwM0css%3D&reserved=0 to complete 2-3 paragraphs on Nsp13 mechanism, and the animation for the paper.
[ ] @tmw20653https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Ftmw20653&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877279344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=QuyuSI1BqfglZ7nUe8J6O0OPv5bDbBPHPZoUebcmOIQ%3D&reserved=0 to set up Google Drive where we can collect documents together
[ ] Matthieu Schapira is working on a section about helihub, and a comparison of human and viral helicases.
[ ] @ahsgchttps://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Fahsgc&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877279344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=7T194I5NBzgJyAcA%2Bra3VZQGm1OJypoh7DYzPYCjutc%3D&reserved=0 to work with other students at UNC (Eugene and Holly Joe?) to complete the list of known helicase inhiitors.
[ ] @tmw20653https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Ftmw20653&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877279344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=QuyuSI1BqfglZ7nUe8J6O0OPv5bDbBPHPZoUebcmOIQ%3D&reserved=0 to write some introductory remarks

5) AOB

[ ] For any future compound design/purchase, @kipUNChttps://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2FkipUNC&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877279344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=Xz4vQSvxBneFoGVsVGWFxW%2FHIMA5JuIFhc4eJ2Iaf28%3D&reserved=0 to filter based on predicted solubility (any other parameters?)
[ ] There is an AViDD open talk this Wed (Nov 16th 2022) where we will discuss the helicase work: https://meetmsk.zoom.us/webinar/register/WN_oH8bnuyvRm-MP0V4NhfE-Q https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fmeetmsk.zoom.us%2Fwebinar%2Fregister%2FWN_oH8bnuyvRm-MP0V4NhfE-Q&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877279344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=7kPb6XA3u1LpP8c%2FoA8tnof1TaQvAtnUic8m1oFYJUc%3D&reserved=0

@jamesday100https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fgithub.com%2Fjamesday100&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877279344%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=uq9mkN6bGp5dodv5kVt%2BqeKv%2FAoO8JWBBaz36mPmpjI%3D&reserved=0 is thanked for his ongoing role as Pharma Champion for this project.

Next Meeting Dec 12th 5pm UK time at https://ucl.zoom.us/j/97172937586 https://eur01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fucl.zoom.us%2Fj%2F97172937586&data=05%7C01%7Cevert.homan%40ki.se%7C1c492cd74d5b428cbc4c08dac6fad591%7Cbff7eef1cf4b4f32be3da1dda043c05d%7C0%7C0%7C638041077877435568%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=UDIbxZnD6HU%2B16NJq%2F1gYjT0TlOpodUPSsqG5%2FGlNzg%3D&reserved=0

L'esprit de l'escalier If you'd like to follow up after the meeting, please comment below. You can also email, but please be clear if anything in the email should not be public domain - the default is open.

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mattodd commented 1 year ago

Sorry @Evert-Homan - my mistake, tagged the wrong team. You can ignore!

StructuralGenomicsConsortium / CNP4-Nsp13-C-terminus-B