Group_85_recurated

[umasrisankarlal]

Hi Anna, Please cross check the recurated batch 85

• directed: true graph: drug: Trichlormethiazide drugbank: DB:DB01021 drug_mesh: MESH:D014237 disease: Hypertension disease_mesh: MESH:D006973 links:
  • key: decreases activity of source: MESH:D014237 target: UniProt:P55017
  • key: increases activity of source: UniProt:P55017 target: GO:0070294
  • key: increases abundance of source: GO:0070294 target: MESH:D012964
  • key: positively correlated with source: MESH:D012964 target: HP:0000822
  • key: manifestation of source: HP:0000822 target: MESH:D006973 multigraph: true nodes:
  • id: MESH:D014237 label: Drug name: Trichlormethiazide
  • id: UniProt:P55017 label: Protein name: Solute carrier family 12 member 3
  • id: GO:0070294 label: BiologicalProcess name: Renal sodium ion absorption
  • id: MESH:D012964 label: ChemicalSubstance name: Sodium
  • id: HP:0000822 label: PhenotypicFeature name: Blood pressure
  • id: MESH:D006973 label: Disease name: Hypertension reference:
  • https://go.drugbank.com/drugs/DB01021
  • https://en.wikipedia.org/wiki/Thiazide
  • https://en.wikipedia.org/wiki/Trichlormethiazide
• directed: true graph: drug: Phenindamine drugbank: DB:DB01619 drug_mesh: MESH:C005430 disease: Urticaria disease_mesh: MESH:D014581 links:
  • key: decreases activity of source: MESH:C005430 target: UniProt:P35367
  • key: positively correlated with source: UniProt:P35367 target: MESH:D006632
  • key: causes source: MESH:D006632 target: GO:0002524
  • key: correlated with source: GO:0002524 target: MESH:D014581 multigraph: true nodes:
  • id: MESH:C005430 label: Drug name: Phenindamine
  • id: UniProt:P35367 label: Protein name: Histamine H1 receptor
  • id: MESH:D006632 label: ChemicalSubstance name: Histamine
  • id: GO:0002524 label: BiologicalProcess name: Hypersensitivity
  • id: MESH:D014581 label: Disease name: Urticaria reference:
  • https://go.drugbank.com/drugs/DB01619
  • https://pubchem.ncbi.nlm.nih.gov/compound/Phenindamine#section=MeSH-Pharmacological-Classification
  • https://en.wikipedia.org/wiki/Antihistamine
• directed: true graph: drug: Phenindamine drugbank: DB:DB01619 drug_mesh: MESH:C005430 disease: Pruritus disease_mesh: MESH:D011537 links:
  • key: decreases activity of source: MESH:C005430 target: UniProt:P35367
  • key: positively correlated with source: UniProt:P35367 target: MESH:D006632
  • key: causes source: MESH:D006632 target: GO:0002524
  • key: correlated with source: GO:0002524 target: MESH:D011537 multigraph: true nodes:
  • id: MESH:C005430 label: Drug name: Phenindamine
  • id: UniProt:P35367 label: Protein name: Histamine H1 receptor
  • id: MESH:D006632 label: ChemicalSubstance name: Histamine
  • id: GO:0002524 label: BiologicalProcess name: Hypersensitivity
  • id: MESH:D011537 label: Disease name: Pruritus reference:
  • https://go.drugbank.com/drugs/DB01619
  • https://pubchem.ncbi.nlm.nih.gov/compound/Phenindamine#section=MeSH-Pharmacological-Classification
  • https://en.wikipedia.org/wiki/Antihistamine
• directed: true graph: drug: Phenindamine drugbank: DB:DB01619 drug_mesh: MESH:C005430 disease: Sneezing disease_mesh: MESH:D012912 links:
  • key: decreases activity of source: MESH:C005430 target: UniProt:P35367
  • key: positively correlated with source: UniProt:P35367 target: MESH:D006632
  • key: causes source: MESH:D006632 target: GO:0002524
  • key: correlated with source: GO:0002524 target: MESH:D012912 multigraph: true nodes:
  • id: MESH:C005430 label: Drug name: Phenindamine
  • id: UniProt:P35367 label: Protein name: Histamine H1 receptor
  • id: MESH:D006632 label: ChemicalSubstance name: Histamine
  • id: GO:0002524 label: BiologicalProcess name: Hypersensitivity
  • id: MESH:D012912 label: Disease name: Sneezing reference:
  • https://go.drugbank.com/drugs/DB01619
  • https://pubchem.ncbi.nlm.nih.gov/compound/Phenindamine#section=MeSH-Pharmacological-Classification
  • https://en.wikipedia.org/wiki/Antihistamine
• directed: true graph: drug: Phenindamine drugbank: DB:DB01619 drug_mesh: MESH:C005430 disease: Allergic rhinitis disease_mesh: MESH:D065631 links:
  • key: decreases activity of source: MESH:C005430 target: UniProt:P35367
  • key: positively correlated with source: UniProt:P35367 target: MESH:D006632
  • key: causes source: MESH:D006632 target: GO:0002524
  • key: correlated with source: GO:0002524 target: MESH:D065631 multigraph: true nodes:
  • id: MESH:C005430 label: Drug name: Phenindamine
  • id: UniProt:P35367 label: Protein name: Histamine H1 receptor
  • id: MESH:D006632 label: ChemicalSubstance name: Histamine
  • id: GO:0002524 label: BiologicalProcess name: Hypersensitivity
  • id: MESH:D065631 label: Disease name: Allergic rhinitis reference:
  • https://go.drugbank.com/drugs/DB01619
  • https://pubchem.ncbi.nlm.nih.gov/compound/Phenindamine#section=MeSH-Pharmacological-Classification
  • https://en.wikipedia.org/wiki/Antihistamine
• directed: true graph: drug: Phenindamine drugbank: DB:DB01619 drug_mesh: MESH:C005430 disease: Vasomotor rhinitis disease_mesh: MESH:D012223 links:
  • key: decreases activity of source: MESH:C005430 target: UniProt:P35367
  • key: positively correlated with source: UniProt:P35367 target: MESH:D006632
  • key: causes source: MESH:D006632 target: GO:0002524
  • key: correlated with source: GO:0002524 target: MESH:D012223 multigraph: true nodes:
  • id: MESH:C005430 label: Drug name: Phenindamine
  • id: UniProt:P35367 label: Protein name: Histamine H1 receptor
  • id: MESH:D006632 label: ChemicalSubstance name: Histamine
  • id: GO:0002524 label: BiologicalProcess name: Hypersensitivity
  • id: MESH:D012223 label: Disease name: Vasomotor rhinitis reference:
  • https://go.drugbank.com/drugs/DB01619
  • https://pubchem.ncbi.nlm.nih.gov/compound/Phenindamine#section=MeSH-Pharmacological-Classification
  • https://en.wikipedia.org/wiki/Antihistamine
• directed: true graph: drug: Phenindamine drugbank: DB:DB01619 drug_mesh: MESH:C005430 disease: Allergic conjunctivitis disease_mesh: MESH:D003233 links:
  • key: decreases activity of source: MESH:C005430 target: UniProt:P35367
  • key: positively correlated with source: UniProt:P35367 target: MESH:D006632
  • key: causes source: MESH:D006632 target: GO:0002524
  • key: correlated with source: GO:0002524 target: MESH:D003233 multigraph: true nodes:
  • id: MESH:C005430 label: Drug name: Phenindamine
  • id: UniProt:P35367 label: Protein name: Histamine H1 receptor
  • id: MESH:D006632 label: ChemicalSubstance name: Histamine
  • id: GO:0002524 label: BiologicalProcess name: Hypersensitivity
  • id: MESH:D003233 label: Disease name: Allergic conjunctivitis reference:
  • https://go.drugbank.com/drugs/DB01619
  • https://pubchem.ncbi.nlm.nih.gov/compound/Phenindamine#section=MeSH-Pharmacological-Classification
  • https://en.wikipedia.org/wiki/Antihistamine
• directed: true graph: drug: Oxitropium drugbank: DB:DB12086 drug_mesh: MESH:C017590 disease: Chronic obstructive lung disease disease_mesh: MESH:D029424 links:
  • key: decreases activity of source: MESH:C017590 target: UniProt:P20309
  • key: causes source: UniProt:P20309 target: GO:0006939
  • key: contributes to source: GO:0006939 target: MESH:D029424 multigraph: true nodes:
  • id: MESH:C017590 label: Drug name: Oxitropium
  • id: UniProt:P20309 label: Protein name: Muscarinic acetylcholine receptor M3
  • id: GO:0006939 label: BiologicalProcess name: Smooth muscle contraction
  • id: MESH:D029424 label: Disease name: Chronic obstructive lung disease reference:
  • https://go.drugbank.com/drugs/DB12086
  • https://drugs.ncats.io/drug/8G15T83E6I comment: Oxitropium is used as Oxitropium bromide for treatment
• directed: true graph: drug: Bimatoprost drugbank: DB:DB00905 drug_mesh: MESH:D000069580 disease: Ocular hypertension disease_mesh: MESH:D009798 links:
  • key: increases transport of source: MESH:D000069580 target: UBERON:0001796
  • key: positively correlated with source: UBERON:0001796 target: HP:0007906
  • key: negatively correlated with source: HP:0007906 target: MESH:D009798 multigraph: true nodes:
  • id: MESH:D000069580 label: Drug name: Bimatoprost
  • id: UBERON:0001796 label: GrossAnatomicalStructure name: Aqueous humor of eyeball
  • id: HP:0007906 label: PhenotypicFeature name: Intraocular pressure
  • id: MESH:D009798 label: Disease name: Ocular hypertension reference:
  • https://go.drugbank.com/drugs/DB00905
  • https://pubchem.ncbi.nlm.nih.gov/compound/Bimatoprost#section=Pharmacology
  • https://en.wikipedia.org/wiki/Bimatoprost
• directed: true graph: drug: Bimatoprost drugbank: DB:DB00905 drug_mesh: MESH:D000069580 disease: Open-angle glaucoma disease_mesh: MESH:D005902 links:
  • key: increases transport of source: MESH:D000069580 target: UBERON:0001796
  • key: positively correlated with source: UBERON:0001796 target: HP:0007906
  • key: negatively correlated with source: HP:0007906 target: MESH:D009798
  • key: contributes to source: MESH:D009798 target: MESH:D005902 multigraph: true nodes:
  • id: MESH:D000069580 label: Drug name: Bimatoprost
  • id: UBERON:0001796 label: GrossAnatomicalStructure name: Aqueous humor of eyeball
  • id: HP:0007906 label: PhenotypicFeature name: Intraocular pressure
  • id: MESH:D009798 label: Disease name: Ocular hypertension
  • id: MESH:D005902 label: Disease name: Open-angle glaucoma reference:
  • https://go.drugbank.com/drugs/DB00905
  • https://pubchem.ncbi.nlm.nih.gov/compound/Bimatoprost#section=Pharmacology
  • https://en.wikipedia.org/wiki/Bimatoprost
• directed: true graph: drug: Caspofungin drugbank: DB:DB00520 drug_mesh: NULL disease: Candidemia disease_mesh: MESH:D058387 links:
  • key: decreases activity of source: DB:DB00520 target: InterPro:IPR003440
  • key: increases abundance of source: InterPro:IPR003440 target: MESH:D005936
  • key: positively correlated with source: MESH:D005936 target: GO:0009272
  • key: in taxon source: GO:0009272 target: NCBITaxon:1535326
  • key: causes source: NCBITaxon:1535326 target: MESH:D058387 multigraph: true nodes:
  • id: DB:DB00520 label: Drug name: Caspofungin
  • id: InterPro:IPR003440 label: Protein name: 1,3-Beta-glucan synthase
  • id: MESH:D005936 label: ChemicalSubstance name: Beta(1,3)-D-glucan
  • id: GO:0009272 label: CellularComponent name: Fungal-type cell wall biogenesis
  • id: NCBITaxon:1535326 label: OrganismTaxon name: Candida
  • id: MESH:D058387 label: Disease name: Candidemia reference:
  • https://go.drugbank.com/drugs/DB00520
  • https://pubchem.ncbi.nlm.nih.gov/compound/Caspofungin#section=Pharmacology-and-Biochemistry
• directed: true graph: drug: Cefditoren pivoxil drugbank: DB:DB01066 drug_mesh: MESH:C057710 disease: Bacterial pneumonia disease_mesh: MESH:D018410 links:
  • key: has metabolite source: MESH:C057710 target: MESH:C073460
  • key: decreases activity of source: MESH:C073460 target: InterPro:IPR001460
  • key: positively correlated with source: InterPro:IPR001460 target: GO:0009252
  • key: contributes to source: GO:0009252 target: GO:0009273
  • key: in taxon source: GO:0009273 target: NCBITaxon:1313
  • key: causes source: NCBITaxon:1313 target: MESH:D018410 multigraph: true nodes:
  • id: MESH:C057710 label: Drug name: Cefditoren pivoxil
  • id: MESH:C073460 label: ChemicalSubstance name: Cefditoren
  • id: InterPro:IPR001460 label: GeneFamily name: Penicillin-binding proteins
  • id: GO:0009252 label: BiologicalProcess name: Peptidoglycan biosynthetic process
  • id: GO:0009273 label: BiologicalProcess name: Peptidoglycan-based cell wall biogenesis
  • id: NCBITaxon:1313 label: OrganismTaxon name: Streptococcus pneumoniae
  • id: MESH:D018410 label: Disease name: Bacterial pneumonia reference:
  • https://go.drugbank.com/drugs/DB01066
  • https://pubchem.ncbi.nlm.nih.gov/compound/Cefditoren-pivoxil#section=Pharmacology-and-Biochemistry comment: Cefditoren pivoxil is the pivaloyloxymethyl ester prodrug of cefditoren
• directed: true graph: drug: Cefditoren pivoxil drugbank: DB:DB01066 drug_mesh: MESH:C057710 disease: Staphylococcal infections disease_mesh: MESH:D013203 links:
  • key: has metabolite source: MESH:C057710 target: MESH:C073460
  • key: decreases activity of source: MESH:C073460 target: InterPro:IPR001460
  • key: positively correlated with source: InterPro:IPR001460 target: GO:0009252
  • key: contributes to source: GO:0009252 target: GO:0009273
  • key: in taxon source: GO:0009273 target: NCBITaxon:1280
  • key: causes source: NCBITaxon:1280 target: MESH:D013203 multigraph: true nodes:
  • id: MESH:C057710 label: Drug name: Cefditoren pivoxil
  • id: MESH:C073460 label: ChemicalSubstance name: Cefditoren
  • id: InterPro:IPR001460 label: GeneFamily name: Penicillin-binding proteins
  • id: GO:0009252 label: BiologicalProcess name: Peptidoglycan biosynthetic process
  • id: GO:0009273 label: BiologicalProcess name: Peptidoglycan-based cell wall biogenesis
  • id: NCBITaxon:1280 label: OrganismTaxon name: Staphylococcus aureus
  • id: MESH:D013203 label: Disease name: Staphylococcal Infections reference:
  • https://go.drugbank.com/drugs/DB01066
  • https://pubchem.ncbi.nlm.nih.gov/compound/Cefditoren-pivoxil#section=Pharmacology-and-Biochemistry comment: Cefditoren pivoxil is the pivaloyloxymethyl ester prodrug of cefditoren
• directed: true graph: drug: Cefditoren pivoxil drugbank: DB:DB01066 drug_mesh: MESH:C057710 disease: Streptococcal infections disease_mesh: MESH:D013290 links:
  • key: has metabolite source: MESH:C057710 target: MESH:C073460
  • key: decreases activity of source: MESH:C073460 target: InterPro:IPR001460
  • key: positively correlated with source: InterPro:IPR001460 target: GO:0009252
  • key: contributes to source: GO:0009252 target: GO:0009273
  • key: in taxon source: GO:0009273 target: NCBITaxon:1314
  • key: causes source: NCBITaxon:1314 target: MESH:D013290 multigraph: true nodes:
  • id: MESH:C057710 label: Drug name: Cefditoren pivoxil
  • id: MESH:C073460 label: ChemicalSubstance name: Cefditoren
  • id: InterPro:IPR001460 label: GeneFamily name: Penicillin-binding proteins
  • id: GO:0009252 label: BiologicalProcess name: Peptidoglycan biosynthetic process
  • id: GO:0009273 label: BiologicalProcess name: Peptidoglycan-based cell wall biogenesis
  • id: NCBITaxon:1314 label: OrganismTaxon name: Streptococcus pyogenes
  • id: MESH:D013290 label: Disease name: Streptococcal Infections reference:
  • https://go.drugbank.com/drugs/DB01066
  • https://pubchem.ncbi.nlm.nih.gov/compound/Cefditoren-pivoxil#section=Pharmacology-and-Biochemistry comment: Cefditoren pivoxil is the pivaloyloxymethyl ester prodrug of cefditoren
• directed: true graph: drug: Cefditoren pivoxil drugbank: DB:DB01066 drug_mesh: MESH:C057710 disease: Pneumococcal pneumonia disease_mesh: MESH:D011018 links:
  • key: has metabolite source: MESH:C057710 target: MESH:C073460
  • key: decreases activity of source: MESH:C073460 target: InterPro:IPR001460
  • key: positively correlated with source: InterPro:IPR001460 target: GO:0009252
  • key: contributes to source: GO:0009252 target: GO:0009273
  • key: in taxon source: GO:0009273 target: NCBITaxon:1313
  • key: causes source: NCBITaxon:1313 target: MESH:D011018 multigraph: true nodes:
  • id: MESH:C057710 label: Drug name: Cefditoren pivoxil
  • id: MESH:C073460 label: ChemicalSubstance name: Cefditoren
  • id: InterPro:IPR001460 label: GeneFamily name: Penicillin-binding proteins
  • id: GO:0009252 label: BiologicalProcess name: Peptidoglycan biosynthetic process
  • id: GO:0009273 label: BiologicalProcess name: Peptidoglycan-based cell wall biogenesis
  • id: NCBITaxon:1313 label: OrganismTaxon name: Streptococcus pneumoniae
  • id: MESH:D011018 label: Disease name: Pneumococcal pneumonia reference: https://go.drugbank.com/drugs/DB01066 https://pubchem.ncbi.nlm.nih.gov/compound/Cefditoren-pivoxil#section=Pharmacology-and-Biochemistry comment: Cefditoren pivoxil is the pivaloyloxymethyl ester prodrug of cefditoren
• directed: true graph: drug: Oteracil drugbank: DB:DB03209 drug_mesh: MESH:D010094 disease: Stomach neoplasms disease_mesh: MESH:D013274 links:
  • key: decreases activity of source: MESH:D010094 target: InterPro:IPR023031
  • key: increases abundance of source: InterPro:IPR023031 target: MESH:D005472
  • key: positively correlated with source: MESH:D005472 target: GO:0097237
  • key: located in source: GO:0097237 target: UBERON:0004786
  • key: correlated with source: UBERON:0004786 target: MESH:D013274 multigraph: true nodes:
  • id: MESH:D010094 label: Drug name: Oteracil
  • id: InterPro:IPR023031 label: GeneFamily name: Orotate phosphoribosyltransferase
  • id: MESH:D005472 label: ChemicalSubstance name: Fluorouracil
  • id: GO:0097237 label: BiologicalProcess name: Cellular response to toxic substance
  • id: UBERON:0004786 label: GrossAnatomicalStructure name: Gastrointestinal system mucosa
  • id: MESH:D013274 label: Disease name: Stomach neoplasms reference:
  • https://go.drugbank.com/drugs/DB03209
  • https://pubchem.ncbi.nlm.nih.gov/compound/Oxonic-Acid#section=Pharmacology-and-Biochemistry
  • https://en.wikipedia.org/wiki/Tegafur/gimeracil/oteracil comment: Oteracil is an adjunct to antineoplastic therapy, used to reduce the toxic side effects associated with chemotherapy.
• directed: true graph: drug: Gemtuzumab ozogamicin drugbank: DB:DB00056 drug_mesh: NULL disease: Acute myeloid leukemia disease_mesh: MESH:D015470 links:
  • key: molecularly interacts with source: DB:DB00056 target: MESH:C571163
  • key: located in source: MESH:C571163 target: CL:0000055
  • key: increases abundance of source: CL:0000055 target: MESH:D000080084
  • key: disrupts source: MESH:D000080084 target: MESH:D004247
  • key: causes source: MESH:D004247 target: MESH:D015470 multigraph: true nodes:
  • id: DB:DB00056 label: Drug name: Gemtuzumab ozogamicin
  • id: MESH:C571163 label: ChemicalSubstance name: CD33 antigen
  • id: CL:0000055 label: Cell name: Blast cell
  • id: MESH:D000080084 label: ChemicalSubstance name: Calicheamicin
  • id: MESH:D004247 label: ChemicalSubstance name: DNA
  • id: MESH:D015470 label: Disease name: Acute myeloid leukemia reference:
  • https://go.drugbank.com/drugs/DB00056
  • http://chemocare.com/chemotherapy/drug-info/gemtuzumab-ozogamicin.aspx comment: Gemtuzumab ozogamicin is a monoclonal anti-CD33 antibody
• directed: true graph: drug: Fludrocortisone acetate drugbank: DB:DB00687 drug_mesh: MESH:C034635 disease: Addison disease disease_mesh: MESH:D000224 links:
  • key: has metabolite source: MESH:C034635 target: MESH:D005438
  • key: increases activity of source: MESH:D005438 target: GO:0070294
  • key: increases activity of source: MESH:D005438 target: GO:0036359
  • key: increases activity of source: MESH:D005438 target: GO:0070295
  • key: decreases abundance of source: GO:0036359 target: MESH:D011188
  • key: regulates source: GO:0070295 target: GO:0050801
  • key: regulates source: GO:0070295 target: HP:0002632
  • key: located in source: MESH:D011188 target: UBERON:0001969
  • key: regulates source: UBERON:0001969 target: HP:0002632
  • key: manifestation of source: HP:0002632 target: MESH:D000224
  • key: increases abundance of source: GO:0070294 target: MESH:D012964
  • key: located in source: MESH:D012964 target: UBERON:0001969
  • key: regulates source: UBERON:0001969 target: GO:0050801
  • key: correlated with source: GO:0050801 target: MESH:D000224 multigraph: true nodes:
  • id: MESH:C034635 label: Drug name: Fludrocortisone acetate
  • id: MESH:D005438 label: ChemicalSubstance name: Fludrocortisone
  • id: GO:0070294 label: BiologicalProcess name: Renal sodium ion absorption
  • id: GO:0036359 label: BiologicalProcess name: Renal potassium excretion
  • id: GO:0070295 label: BiologicalProcess name: Renal water absorption
  • id: MESH:D011188 label: ChemicalSubstance name: Potassium
  • id: HP:0002632 label: PhenotypicFeature name: Blood pressure
  • id: MESH:D012964 label: ChemicalSubstance name: Sodium
  • id: UBERON:0001969 label: GrossAnatomicalStructure name: Blood plasma
  • id: GO:0050801 label: BiologicalProcess name: Ion homeostasis
  • id: MESH:D000224 label: Disease name: Addison disease reference:
  • https://go.drugbank.com/drugs/DB00687
  • https://pubchem.ncbi.nlm.nih.gov/compound/Fludrocortisone#section=Pharmacology comment: Fludrocortisone acetate is a prodrug of fludrocortisone, a synthetic mineralocorticoid used in conjunction with hydrocortisone
• directed: true comment: Fludrocortisone acetate is a prodrug of fludrocortisone, a synthetic mineralocorticoid used in conjunction with hydrocortisone graph: drug: Fludrocortisone acetate drugbank: DB:DB00687 drug_mesh: MESH:C034635 disease: Congenital adrenal hyperplasia disease_mesh: MESH:D000312 links:
  • key: has metabolite source: MESH:C034635 target: MESH:D005438
  • key: increases activity of source: MESH:D005438 target: GO:0070294
  • key: increases activity of source: MESH:D005438 target: GO:0036359
  • key: increases activity of source: MESH:D005438 target: GO:0070295
  • key: decreases abundance of source: GO:0036359 target: MESH:D011188
  • key: regulates source: GO:0070295 target: GO:0050801
  • key: regulates source: GO:0070295 target: HP:0002632
  • key: located in source: MESH:D011188 target: UBERON:0001969
  • key: regulates source: UBERON:0001969 target: HP:0002632
  • key: manifestation of source: HP:0002632 target: MESH:D000312
  • key: increases abundance of source: GO:0070294 target: MESH:D012964
  • key: located in source: MESH:D012964 target: UBERON:0001969
  • key: regulates source: UBERON:0001969 target: GO:0050801
  • key: manifestation of source: GO:0050801 target: MESH:D000312 multigraph: true nodes:
  • id: MESH:C034635 label: Drug name: Fludrocortisone acetate
  • id: MESH:D005438 label: ChemicalSubstance name: Fludrocortisone
  • id: GO:0070294 label: BiologicalProcess name: Renal sodium ion absorption
  • id: GO:0036359 label: BiologicalProcess name: Renal potassium excretion
  • id: GO:0070295 label: BiologicalProcess name: Renal water absorption
  • id: MESH:D011188 label: ChemicalSubstance name: Potassium
  • id: HP:0002632 label: PhenotypicFeature name: Blood pressure
  • id: MESH:D012964 label: ChemicalSubstance name: Sodium
  • id: UBERON:0001969 label: GrossAnatomicalStructure name: Blood plasma
  • id: GO:0050801 label: BiologicalProcess name: Ion homeostasis
  • id: MESH:D000312 label: Disease name: Congenital adrenal hyperplasia reference: https://go.drugbank.com/drugs/DB00687 https://pubchem.ncbi.nlm.nih.gov/compound/Fludrocortisone#section=Pharmacology https://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia
• directed: true comment: Fluoxymesterone is a synthetic androgen, or male hormone, similar to testosterone graph: drug: Fluoxymesterone drugbank: DB:DB01185 drug_mesh: MESH:D005474 disease: Delayed puberty disease_mesh: MESH:D011628 links:
  • key: increases activity of source: MESH:D005474 target: UniProt:P10275
  • key: positively regulates source: UniProt:P10275 target: GO:0030521
  • key: positively correlated with source: GO:0030521 target: GO:0045136
  • key: negatively correlated with source: GO:0045136 target: MESH:D011628 multigraph: true nodes:
  • id: MESH:D005474 label: Drug name: Fluoxymesterone
  • id: UniProt:P10275 label: Protein name: Androgen receptor
  • id: GO:0030521 label: BiologicalProcess name: Androgen receptor signaling pathway
  • id: GO:0045136 label: BiologicalProcess name: Development of secondary sexual characteristics
  • id: MESH:D011628 label: Disease name: Delayed puberty reference: https://go.drugbank.com/drugs/DB01185 https://en.wikipedia.org/wiki/Fluoxymesterone https://en.wikipedia.org/wiki/Androgen
• directed: true comment: Fluoxymesterone is a synthetic androgen, or male hormone, similar to testosterone graph: drug: Fluoxymesterone drugbank: DB:DB01185 drug_mesh: MESH:D005474 disease: Klinefelter Syndrome disease_mesh: MESH:D007713 links:
  • key: increases activity of source: MESH:D005474 target: UniProt:P10275
  • key: positively regulates source: UniProt:P10275 target: GO:0030521
  • key: positively correlated with source: GO:0030521 target: GO:0046544
  • key: negatively correlated with source: GO:0046544 target: MESH:D007713 multigraph: true nodes:
  • id: MESH:D005474 label: Drug name: Fluoxymesterone
  • id: UniProt:P10275 label: Protein name: Androgen receptor
  • id: GO:0030521 label: BiologicalProcess name: Androgen receptor signaling pathway
  • id: GO:0046544 label: BiologicalProcess name: Development of secondary male sexual characteristics
  • id: MESH:D007713 label: Disease name: Klinefelter Syndrome reference: https://go.drugbank.com/drugs/DB01185 https://en.wikipedia.org/wiki/Fluoxymesterone https://en.wikipedia.org/wiki/Androgen
• directed: true comment: Fluoxymesterone is a synthetic androgen, or male hormone, similar to testosterone graph: drug: Fluoxymesterone drugbank: DB:DB01185 drug_mesh: MESH:D005474 disease: Cryptorchidism disease_mesh: MESH:D003456 links:
  • key: decreases synthesis of source: MESH:D005474 target: MESH:D007986
  • key: increases abundance of source: MESH:D007986 target: MESH:D000728
  • key: positively regulates source: MESH:D000728 target: GO:0030521
  • key: contributes to source: GO:0030521 target: GO:0007283
  • key: manifestation of source: GO:0007283 target: MESH:D003456 multigraph: true nodes:
  • id: MESH:D005474 label: Drug name: Fluoxymesterone
  • id: MESH:D007986 label: ChemicalSubstance name: Luteinizing hormone
  • id: MESH:D000728 label: ChemicalSubstance name: Androgen
  • id: GO:0030521 label: BiologicalProcess name: Androgen receptor signaling pathway
  • id: GO:0007283 label: BiologicalProcess name: Spermatogenesis
  • id: MESH:D003456 label: Disease name: Cryptorchidism reference: https://go.drugbank.com/drugs/DB01185 https://en.wikipedia.org/wiki/Fluoxymesterone https://en.wikipedia.org/wiki/Androgen https://en.wikipedia.org/wiki/Cryptorchidism#:~:text=Cryptorchidism%20is%20the%20absence%20of,of%20the%20male%20genital%20tract.
• directed: true comment: Fluoxymesterone is a synthetic androgen, or male hormone, similar to testosterone. No clear mechanism of action is found in literature evidences. graph: drug: Fluoxymesterone drugbank: DB:DB01185 drug_mesh: MESH:D005474 disease: Eunuchism disease_mesh: MESH:D005058 links:
  • key: increases activity of source: MESH:D005474 target: UniProt:P10275
  • key: positively regulates source: UniProt:P10275 target: GO:0030521
  • key: positively correlated with source: GO:0030521 target: GO:0046544
  • key: negatively correlated with source: GO:0046544 target: MESH:D005058 multigraph: true nodes:
  • id: MESH:D005474 label: Drug name: Fluoxymesterone
  • id: UniProt:P10275 label: Protein name: Androgen receptor
  • id: GO:0030521 label: BiologicalProcess name: Androgen receptor signaling pathway
  • id: GO:0046544 label: BiologicalProcess name: Development of secondary male sexual characteristics
  • id: MESH:D005058 label: Disease name: Eunuchism reference: https://go.drugbank.com/drugs/DB01185 https://en.wikipedia.org/wiki/Fluoxymesterone https://en.wikipedia.org/wiki/Androgen
• directed: true comment: No literature evidences found about the mechanism of action of Fluoxymesterone treating Myotonia Congenita graph: drug: Fluoxymesterone drugbank: DB:DB01185 drug_mesh: MESH:D005474 disease: Myotonia Congenita disease_mesh: MESH:D009224 links:
  • key: treats source: MESH:D005474 target: MESH:D009224 multigraph: true nodes:
  • id: MESH:D005474 label: Drug name: Fluoxymesterone
  • id: MESH:D009224 label: Disease name: Myotonia Congenita reference: https://go.drugbank.com/drugs/DB01185
• directed: true comment: No literature evidences found about the mechanism of action of Fluoxymesterone treating Noonan syndrome graph: drug: Fluoxymesterone drugbank: DB:DB01185 drug_mesh: MESH:D005474 disease: Noonan syndrome disease_mesh: MESH:D009634 links:
  • key: treats source: MESH:D005474 target: MESH:D009634 multigraph: true nodes:
  • id: MESH:D005474 label: Drug name: Fluoxymesterone
  • id: MESH:D009634 label: Disease name: Noonan syndrome reference: https://go.drugbank.com/drugs/DB01185

[umasrisankarlal]

Commented in Curating_batch_85 as suggested by Anna, hence closing this issue