SysBioChalmers / Human-GEM

The generic genome-scale metabolic model of Homo sapiens
https://sysbiochalmers.github.io/Human-GEM-guide/
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MAM00154r, strange references #328

Closed ANiknejad closed 2 years ago

ANiknejad commented 2 years ago

https://metabolicatlas.org/explore/Human-GEM/gem-browser/metabolite/MAM00154r

MAM00154r is (Glc)3 (GlcNAc)2 (Man)9 (PP-Dol)1
and should have a xref to CHEBI:53019 (glycan G00008, synonym (Glc)3(GlcNAc)2(Man)9(PP-Dol)1 ). And as far as I understand, BiGG g3m8mpdol__L is another compound: (alpha-D-Glucosyl)3-(alpha-D-mannosyl)8-beta-D-mannosyl-diacetylchitobiosyldiphosphodolichol ? And not sure this BiGG compound even exists, actually, see this reference here: https://academic.oup.com/glycob/article/14/5/399/611433 'Across kingdoms, nearly every eukaryote studied to date synthesizes N-glycans in the same way, assembling an identical Glc3Man9GlcNAc2 glycan as a lipid-linked moiety with dolichyl pyrophosphate (Dol-PP) and transferring this to Asn residues on nascent proteins in the endoplasmic reticulum (ER)'

Also I do not understand the 'Related metabolite(s)' = palmitoyl-CoA (sorry in advance if I missed a point here)

(Note that we are currently doing reconciliation from our side for MNXM147644)

What do you think? @Hao-Chalmers

I hereby confirm that I have:

haowang-bioinfo commented 2 years ago

@ANiknejad thanks for reporting this.

I think you can move on to make the changes as proposed. Furthermore, I would suggest you to directly make PRs for the nice contribution in ChEBI id curation in future, and skip the step of having an issue. It should be enough to provide supporting evidence as commit messages if any. What do you think?