MAR03433 represents the complete beta-oxidation of 10,13,16,19-docosatetraenoyl-CoA in a single step, and MAR03427 does the same for (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA. (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA can also be completely beta-oxidized to acetyl-CoA by MAR00922 + MAR05365 + MAR05369 + MAR05298 + MAR05312 + MAR05306 + MAR05242 + MAR05177 + MAR05090 + MAR05083 + MAR04978 + MAR05001 + MAR04988 + MAR04984 +MAR06320 + MAR06281 + MAR03157 + MAR03158 + MAR03160 + MAR03163 + MAR03164 + MAR03166 + MAR03885 (see #722).
Expected feature/value/output:
One full round of beta-oxidation of 10,13,16,19-docosatetraenoyl-CoA would produce (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA, so I think MAR03433 should be edited to represent just one round of beta-oxidation of 10,13,16,19-docosatetraenoyl-CoA, rather than all of them. I think MAR03427 should be removed for being redundant with the longer, more detailed series of reactions starting with MAR00922.
Proposed changes:
[ ] Edit MAR03433 to be 10,13,16,19-docosatetraenoyl-CoA + FAD + H2O + NAD+ + CoA -> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + FADH2 + NADH + H+ + acetyl-CoA, GPR: (ACAD9 or ACADL or ACADVL) and HADHA and HADHB
Current behavior:
MAR03433represents the complete beta-oxidation of 10,13,16,19-docosatetraenoyl-CoA in a single step, andMAR03427does the same for (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA. (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA can also be completely beta-oxidized to acetyl-CoA byMAR00922+MAR05365+MAR05369+MAR05298+MAR05312+MAR05306+MAR05242+MAR05177+MAR05090+MAR05083+MAR04978+MAR05001+MAR04988+MAR04984+MAR06320+MAR06281+MAR03157+MAR03158+MAR03160+MAR03163+MAR03164+MAR03166+MAR03885(see #722).Expected feature/value/output:
One full round of beta-oxidation of 10,13,16,19-docosatetraenoyl-CoA would produce (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA, so I think
MAR03433should be edited to represent just one round of beta-oxidation of 10,13,16,19-docosatetraenoyl-CoA, rather than all of them. I thinkMAR03427should be removed for being redundant with the longer, more detailed series of reactions starting withMAR00922.Proposed changes:
MAR03433to be 10,13,16,19-docosatetraenoyl-CoA + FAD + H2O + NAD+ + CoA -> (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoA + FADH2 + NADH + H+ + acetyl-CoA, GPR:(ACAD9 or ACADL or ACADVL) and HADHA and HADHBMAR03427for being a duplicate ofMAR00922+MAR05365+MAR05369+MAR05298+MAR05312+MAR05306+MAR05242+MAR05177+MAR05090+MAR05083+MAR04978+MAR05001+MAR04988+MAR04984+MAR06320+MAR06281+MAR03157+MAR03158+MAR03160+MAR03163+MAR03164+MAR03166+MAR03885