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SysBioChalmers / Human-GEM

The generic genome-scale metabolic model of Homo sapiens
https://sysbiochalmers.github.io/Human-GEM-guide/
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Duplicate Lauroyl-CoA Beta-Oxidation Reactions #799

Open Devlin-Moyer opened 9 months ago

Devlin-Moyer commented 9 months ago

MAR05098 appears to be a duplicate of MAR03135 + MAR03136, and MAR05095 appears to be a duplicate of MAR03135 + MAR03136 + MAR03137 + MAR03139:

ID Reaction GPR
MAR03135 FAD [m] + lauroyl-CoA [m] --> (2E)-dodecenoyl-CoA [m] + FADH2 [m] ACADVL or ACADL or ACADM or ACAD9
MAR03136 (2E)-dodecenoyl-CoA [m] + H2O [m] --> (S)-3-hydroxydodecanoyl-CoA [m] HADHA and EHHADH and ECHS1
MAR03137 (S)-3-hydroxydodecanoyl-CoA [m] + NAD+ [m] --> 3-oxododecanoyl-CoA [m] + H+ [m] + NADH [m] HSD17B10 and HADHA and HADH
MAR03139 3-oxododecanoyl-CoA [m] + CoA [m] --> acetyl-CoA [m] + decanoyl-CoA [m] HADHA and HADHB and ACAA2
MAR05098 FAD [m] + H2O [m] + lauroyl-CoA [m] --> (S)-3-hydroxydodecanoyl-CoA [m] + FADH2 [m] ACADM and ECHS1
MAR05095 CoA [m] + FAD [m] + H2O [m] + lauroyl-CoA [m] + NAD+ [m] --> acetyl-CoA [m] + decanoyl-CoA [m] + FADH2 [m] + H+ [m] + NADH [m] ACADM and ECHS1 and HADH and ACAA2

I think both MAR05098 and MAR05095 should be removed.