SysBioChalmers / Human-GEM

The generic genome-scale metabolic model of Homo sapiens
https://sysbiochalmers.github.io/Human-GEM-guide/
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GPR curation for Transport reactions (16) #921

Open JHL-452b opened 1 week ago

JHL-452b commented 1 week ago

50 genes are discovered to be uncorrelated with their corresponding reactions in Transport reactions.

Gene UniProtID Reaction GPR Correlation Manually check
ENSG00000103064 Q92536 MAR05608: alanine + Na+ + tyrosine --> alanine + Na+ + tyrosine ENSG00000103064 or ENSG00000103257 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 is annotated to function mainly as an antiporter for cationic and neutral amino acids, especially L-arginine, in exchange for other amino acids like L-leucine, L-glutamine, L-lysine, and others, often in the presence of sodium ions. The catalytic activities listed do not mention alanine or tyrosine as substrates. The provided reaction involves the transport of alanine and tyrosine along with sodium, which is not one of the known transport activities of this gene. Therefore, the gene is not related to this reaction. No
ENSG00000103064 Q92536 MAR05615: alanine + homoserine + Na+ --> alanine + homoserine + Na+ ENSG00000103064 or ENSG00000103257 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 codes for a protein that acts as an antiporter involved in the exchange of cationic amino acids like L-arginine with neutral amino acids such as L-leucine, L-glutamine, and L-isoleucine, along with sodium ions. The reactions described in the gene's annotations involve various amino acid exchanges where L-arginine is a constant participant and sodium ions may or may not be involved. However, the provided reaction describes an interaction between alanine, homoserine, and sodium, which does not align with the substrate specificity of the gene product. Therefore, the gene ENSG00000103064 and the provided reaction are not related. No
ENSG00000103064 Q92536 MAR05627: asparagine + glutamine + Na+ --> asparagine + glutamine + Na+ ENSG00000103064 or ENSG00000105281 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 functions primarily as an antiporter exchanging L-arginine with various amino acids like L-leucine, L-glutamine, and L-lysine in a sodium-dependent or sodium-independent manner. The reactions specified in the provided information involve L-arginine exchanges, whereas the given reaction involves the exchange of asparagine and glutamine with sodium ions. There is no evidence that the gene is involved in this specific reaction with asparagine and glutamine. No
ENSG00000103064 Q92536 MAR05640: leucine + Na+ + serine --> leucine + Na+ + serine ENSG00000103064 or ENSG00000103257 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 is involved in the transport of cationic and neutral amino acids, such as L-arginine, L-leucine, L-glutamine, and others in exchange processes, often involving sodium ions, but the reaction provided (leucine + Na+ + serine --> leucine + Na+ + serine) does not involve such exchange processes and does not include L-arginine or any other amino acids listed in connection with the gene's catalytic activities. Therefore, the gene is not relevant to the reaction provided. No
ENSG00000103064 Q92536 MAR05653: methionine + Na+ + tyrosine --> methionine + Na+ + tyrosine ENSG00000103064 or ENSG00000103257 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions as an antiporter involved in the exchange of L-arginine with various amino acids and sodium ions, as described in multiple catalytic activities. However, the reaction provided involves methionine, sodium, and tyrosine, which does not correspond to any of the specific exchanges or transport activities attributed to the gene product. Therefore, the gene and the reaction are not related. No
ENSG00000103064 Q92536 MAR05659: methionine + Na+ + threonine --> methionine + Na+ + threonine ENSG00000103064 or ENSG00000103257 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, mediating the transport of various amino acids such as L-arginine, L-leucine, and others, often in exchange with sodium ions. The specific reactions catalyzed by this gene product involve the exchange of amino acids like L-arginine with L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, or L-methionine, none of which include threonine as a substrate. The provided reaction involves methionine, Na+, and threonine, which does not match any of the documented catalytic activities of the gene product. Therefore, the gene is not related to the provided reaction. No
ENSG00000103064 Q92536 MAR05675: homoserine + Na+ + tryptophan --> homoserine + Na+ + tryptophan ENSG00000103064 or ENSG00000103257 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 is annotated as encoding for a protein that functions as an antiporter involved in the exchange of cationic and neutral amino acids, such as L-arginine and L-leucine, and may participate in nitric oxide synthesis. The described transport reactions specifically involve exchanges of L-arginine with various amino acids and sodium ions. However, the provided reaction is "homoserine + Na+ + tryptophan --> homoserine + Na+ + tryptophan," which does not involve L-arginine or any of the specific exchanges mediated by the gene's protein product. Hence, there is no relevance between the gene and the given reaction. No
ENSG00000103064 Q92536 MAR05686: Na+ + phenylalanine + proline --> Na+ + phenylalanine + proline ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. According to the annotation, the gene ENSG00000103064 encodes a protein that functions as an antiporter, mainly exchanging L-arginine with other amino acids such as L-lysine, L-leucine, L-glutamine, and sodium ions, among others. This gene's functions and catalytic activities are specifically related to these exchanges. However, the reaction provided, which involves Na+, phenylalanine, and proline, does not align with the known functions and catalytic activities of the encoded protein. Therefore, the gene is not relevant to the described reaction. No
ENSG00000103064 Q92536 MAR05690: homoserine + Na+ + phenylalanine --> homoserine + Na+ + phenylalanine ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions as an antiporter involved in exchanging cationic and neutral amino acids such as L-arginine and L-leucine, along with sodium ions. However, the reaction provided involves homoserine, sodium ions, and phenylalanine, which are not part of the substrates or products involved in the gene¡¯s annotated catalytic activities. Therefore, the gene is not related to the provided reaction. No
ENSG00000103064 Q92536 MAR05696: methionine + Na+ + tyrosine --> methionine + Na+ + tyrosine ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 is involved in the exchange of L-arginine with other amino acids such as L-lysine, L-leucine, L-glutamine, and others, along with sodium ions. However, the provided reaction involving methionine, Na+, and tyrosine does not match any of the catalytic activities described for the gene. Therefore, the gene is not relevant to the reaction provided. No
ENSG00000103064 Q92536 MAR05717: asparagine + cysteine + Na+ --> asparagine + cysteine + Na+ ENSG00000103064 or ENSG00000105281 or ENSG00000115902 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes for a protein that functions as an antiporter exchanging L-arginine with various neutral or cationic amino acids in the presence or absence of sodium ions. The transport mechanisms described include the exchange of L-arginine with L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine. However, the provided reaction involves asparagine and cysteine along with sodium (asparagine + cysteine + Na+ --> asparagine + cysteine + Na+), which does not align with the known catalytic activities of the antiporter encoded by this gene. Therefore, the gene and the provided reaction are not related. No
ENSG00000103064 Q92536 MAR05720: cysteine + homoserine + Na+ --> cysteine + homoserine + Na+ ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, facilitating the exchange of various amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, often in association with sodium ions. The provided reaction involves cysteine, homoserine, and sodium, which does not align with the specifc amino acid exchanges catalyzed by the gene product. Therefore, the reaction does not match the functions ascribed to the gene. No
ENSG00000103064 Q92536 MAR05734: leucine + Na+ + threonine --> leucine + Na+ + threonine ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 functions as an antiporter involved in the exchange of specific amino acids such as L-arginine, L-leucine, L-glutamine, and others, as well as sodium ions. The annotated catalytic activities involve various exchanges with L-arginine, but none mention threonine as a substrate. The provided reaction involves leucine, Na+, and threonine, which does not match any of the catalytic activities associated with the gene. Therefore, the gene and the reaction are not related. No
ENSG00000103064 Q92536 MAR05741: methionine + Na+ + proline --> methionine + Na+ + proline ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, primarily involved in the exchange of various amino acids such as L-arginine, L-leucine, L-glutamine, isoleucine, L-lysine and others, often in a sodium-dependent or independent mechanism. The reactions catalyzed by this gene's product do not include the interaction of methionine, Na+, and proline as described in the provided reaction. Therefore, the gene ENSG00000103064 does not relate to the reaction "methionine + Na+ + proline --> methionine + Na+ + proline." No
ENSG00000103064 Q92536 MAR05742: Na+ + proline + tryptophan --> Na+ + proline + tryptophan ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter for cationic and neutral amino acids, facilitating the exchange of amino acids like L-arginine, L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, often in conjunction with sodium ions. The described catalytic activities do not include the simultaneous transport of proline and tryptophan as stated in the given reaction. Therefore, the gene's function does not correspond to or impact the provided reaction. No
ENSG00000103064 Q92536 MAR05744: Na+ + proline + tyrosine --> Na+ + proline + tyrosine ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes for a protein that functions as an antiporter, facilitating the exchange of cationic amino acids such as L-arginine with neutral amino acids like L-leucine, L-glutamine, and isoleucine, with the involvement of sodium ions. The reactions catalyzed by this gene involve the exchange of specific amino acids, primarily focusing on L-arginine, L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine. However, the provided reaction involves the exchange of Na+, proline, and tyrosine, which does not match any of the catalytic activities described for this gene. Therefore, the gene is not relevant to the specified reaction. No
ENSG00000103064 Q92536 MAR05749: Na+ + proline + threonine --> Na+ + proline + threonine ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The annotated function of gene ENSG00000103064 involves the transport of L-arginine and other amino acids such as L-leucine, L-glutamine, L-lysine, L-histidine, L-cysteine, and L-methionine in exchange processes. However, the reaction provided involves Na+, proline, and threonine, which are not mentioned in the catalytic activities of the gene. Therefore, the gene is unrelated to the specific reaction involving Na+, proline, and threonine. No
ENSG00000103064 Q92536 MAR05766: asparagine + isoleucine + Na+ --> asparagine + isoleucine + Na+ ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter for cationic and neutral amino acids, such as L-arginine, L-leucine, and others, often in a sodium-dependent manner. The protein's catalytic activities involve the exchange of these amino acids across the cell membrane. However, the reaction provided, which involves asparagine, isoleucine, and sodium ions without changing their positions, does not align with the functions or catalytic activities described for this gene. Therefore, the gene is not relevant to the reaction provided. No
ENSG00000103064 Q92536 MAR05787: Na+ + threonine + tryptophan --> Na+ + threonine + tryptophan ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes for a protein that functions as an antiporter, primarily facilitating the exchange of cationic and neutral amino acids, such as L-arginine, L-leucine, L-glutamine, and other related compounds, often involving sodium ions. The specific reactions it catalyzes involve the transport of L-arginine with various amino acids like L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, typically in an electroneutral manner. However, the provided reaction involves the transfer of threonine and tryptophan, none of which are mentioned as substrates for the transporter protein encoded by ENSG00000103064. Therefore, based on the annotation and known catalytic activities of this gene, it is not involved in the reaction stated. No
ENSG00000103064 Q92536 MAR05799: glutamine + homoserine + Na+ --> glutamine + homoserine + Na+ ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes for a protein that functions primarily as an antiporter, facilitating the exchange of various amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, and others, often in a sodium-dependent manner. The annotated catalytic activities described for this gene involve specific exchanges of amino acids, none of which include homoserine, a key substrate in the provided reaction. Therefore, the gene's annotated function does not align with or support the provided reaction (glutamine + homoserine + Na+ --> glutamine + homoserine + Na+), indicating that the gene is unrelated to this reaction. No
ENSG00000103064 Q92536 MAR05801: homoserine + methionine + Na+ --> homoserine + methionine + Na+ ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, responsible for exchanging cationic amino acids, such as L-arginine, with neutral amino acids, and in some cases, in the presence of sodium ions. This activity is specific to amino acids such as L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine. The reaction provided involves the interaction of homoserine, methionine, and sodium ions, which is not related to the transport functions of the gene's encoded protein. Therefore, the gene and the reaction are not related. No
ENSG00000103064 Q92536 MAR05810: homoserine + Na+ + threonine --> homoserine + Na+ + threonine ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter exchanging cationic amino acids like L-arginine with neutral amino acids such as L-leucine, L-glutamine, and isoleucine, plus sodium ions. However, the provided reaction involves homoserine, Na+, and threonine, which are not substrates or products related to the catalytic activities documented for this gene. Therefore, there is no direct connection between the gene and the reaction specified. No
ENSG00000103064 Q92536 MAR05811: homoserine + isoleucine + Na+ --> homoserine + isoleucine + Na+ ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes for a protein that functions as an antiporter, primarily involved in the exchange of cationic and neutral amino acids such as L-arginine, L-leucine, and L-glutamine, along with sodium ions. However, the reaction provided involves the exchange of homoserine and isoleucine with sodium ions, which is not one of the reactions catalyzed by the protein encoded by this gene. Therefore, the gene does not have any relevance to the provided reaction. No
ENSG00000103064 Q92536 MAR05815: isoleucine + Na+ + serine --> isoleucine + Na+ + serine ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that catalyzes the exchange of L-arginine with other amino acids such as L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, often in the presence of Na+ ions. However, the provided reaction involves isoleucine and serine, which are not part of the catalytic activities listed for this gene. Therefore, the reaction is not related to the gene ENSG00000103064. No
ENSG00000103064 Q92536 MAR05825: isoleucine + Na+ + threonine --> isoleucine + Na+ + threonine ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions as an antiporter, facilitating the exchange of certain amino acids such as L-arginine, L-leucine, and L-glutamine, usually in the presence of sodium ions. However, the reaction provided involves isoleucine and threonine and does not align with any of the catalytic activities described for the gene product in the annotated functions. Therefore, the gene and the reaction are not related. No
ENSG00000103064 Q92536 MAR05827: glycine + lysine + Na+ --> glycine + lysine + Na+ ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENCODES a protein that functions mainly as an antiporter for cationic and neutral amino acids such as L-arginine, L-leucine, L-glutamine, and others, and can also transport L-arginine and L-lysine. However, the reaction provided involves the transport of glycine and lysine in association with Na+ ions. There is no evidence or annotation supporting that the antiporter involves glycine in its transport activity. Therefore, the gene does not relate to the reaction provided involving glycine. Yes
ENSG00000103064 Q92536 MAR05831: citrulline + glycine + Na+ --> citrulline + glycine + Na+ ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 encodes a protein that functions as an antiporter, exchanging L-arginine and other amino acids, sometimes in a sodium-dependent manner. The various catalytic activities mentioned involve the transportation of L-arginine in exchange for L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine. None of these activities involve the reaction "citrulline + glycine + Na+ --> citrulline + glycine + Na+." Therefore, the gene's function does not correspond to the reaction provided. No
ENSG00000103064 Q92536 MAR05856: citrulline + Na+ + tryptophan --> citrulline + Na+ + tryptophan ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, primarily facilitating the exchange of L-arginine with various neutral amino acids (such as leucine, glutamine, histidine, cysteine, and methionine) as well as L-lysine, in the presence of sodium ions. The annotated catalytic activities and the described functions do not involve the specific reaction provided, which is the conversion of citrulline and tryptophan in the presence of sodium. Therefore, the gene product does not participate in the given reaction involving citrulline and tryptophan. No
ENSG00000103064 Q92536 MAR05892: lysine + Na+ + threonine --> lysine + Na+ + threonine ENSG00000103064 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The catalytic activities associated with the gene ENSG00000103064 primarily involve the exchange of L-arginine with various other amino acids such as L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, typically in the presence of sodium ions. In contrast, the provided reaction (lysine + Na+ + threonine --> lysine + Na+ + threonine) does not align with any of these documented activities or exchanges, indicating that the gene does not pertain to this specific reaction. Yes
ENSG00000021488 P82251 MAR05920: lysine + threonine --> lysine + threonine ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes a transporter protein that mediates the exchange between cationic amino acids and neutral amino acids. It specifically catalyzes reactions involving amino acids such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The provided reaction involves lysine and threonine, which does not match any of the documented catalytic activities associated with the gene. Therefore, based on the gene's function and the specific reactions it catalyzes, there is no relevance to the reaction lysine + threonine --> lysine + threonine. Yes
ENSG00000021488 P82251 MAR05922: isoleucine + lysine --> isoleucine + lysine ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes a transporter complex that mediates the exchange of specific amino acids, primarily involving L-arginine with other amino acids like L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the reaction provided involves the exchange between isoleucine and lysine, which is not listed among the catalytic activities of the gene. Therefore, the gene ENSG00000021488 does not participate in the isoleucine and lysine exchange reaction. Yes
ENSG00000021488 P82251 MAR05925: arginine + glutamine --> arginine + glutamine ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes a transporter protein that mediates the exchange of cationic amino acids and neutral amino acids, specifically involving L-arginine and several other amino acids such as L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The provided reaction (arginine + glutamine --> arginine + glutamine) does not match the catalytic activities or specific amino acid exchanges associated with this gene's function, as it does not involve the exchange or transport of the mentioned amino acids. Yes
ENSG00000103064 Q92536 MAR05928: arginine + tryptophan --> arginine + tryptophan ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000103064 functions primarily as an antiporter for cationic and neutral amino acids, specifically exchanging L-arginine with other amino acids like L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, often in the presence of sodium ions. The reactions it catalyzes involve the exchange of L-arginine with these specific amino acids, but not with tryptophan. The provided reaction involves arginine and tryptophan, which is not listed among the substrates the gene's product exchanges. Therefore, based on the annotation of the gene, it is not related to the provided reaction. Yes
ENSG00000021488 P82251 MAR05950: asparagine + ornithine --> asparagine + ornithine ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 is involved in the exchange of cationic amino acids and neutral amino acids, specifically reactions involving L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The given reaction, asparagine + ornithine --> asparagine + ornithine, does not involve any of these amino acids or the specific transporter activity associated with the gene. Therefore, the gene's function and known catalytic activities do not relate to the provided reaction. Yes
ENSG00000103064 Q92536 MAR05950: asparagine + ornithine --> asparagine + ornithine ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions primarily as an antiporter for cationic and neutral amino acids, such as L-arginine, L-leucine, L-glutamine, and L-lysine, among others. The catalytic activities of this gene involve the exchange of L-arginine with other amino acids along with sodium ions. In contrast, the given reaction is an interconversion between asparagine and ornithine, which is not related to the amino acids or the exchange mechanisms described for the gene ENSG00000103064. Therefore, the gene and the reaction are not related. Yes
ENSG00000103064 Q92536 MAR05951: ornithine + valine --> ornithine + valine ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENCODES a protein that functions mainly as an antiporter for cationic and neutral amino acids, primarily exporting L-arginine in exchange for other amino acids like L-leucine, L-glutamine, and L-lysine. The annotated catalytic activities include several specific exchanges of L-arginine with various amino acids, but none of these reactions involve the transformation of ornithine and valine as described in the provided reaction. Therefore, the gene's function does not relate to the reaction of ornithine and valine. Yes
ENSG00000021488 P82251 MAR05952: ornithine + threonine --> ornithine + threonine ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes a transporter that mediates the exchange between cationic and neutral amino acids, specifically catalyzing the exchange of L-arginine with various amino acids such as L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the provided reaction involves the exchange between ornithine and threonine, which is not among the substrates mentioned for the gene's transporter activity. Therefore, based on the provided annotation, the gene is not related to the given reaction. Yes
ENSG00000021488 P82251 MAR05955: glycine + histidine --> glycine + histidine ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes a protein involved in the exchange of cationic amino acids and neutral amino acids, such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the reaction provided involves only the exchange between glycine and histidine. This specific exchange is not documented as a function or catalytic activity of the protein encoded by ENSG00000021488, indicating that the gene and the reaction are not related. Yes
ENSG00000103064 Q92536 MAR05955: glycine + histidine --> glycine + histidine ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter involved in the exchange of cationic and neutral amino acids such as L-arginine, L-lysine, L-leucine, L-glutamine, L-histidine, L-cysteine, and L-methionine, with a specific role in processes like nitric oxide synthesis and transport mechanisms in various cells. However, the provided reaction involves glycine and histidine, which does not match the catalytic activities described for the gene product. Therefore, there is no relevance between the gene's function and the provided reaction. Yes
ENSG00000021488 P82251 MAR05960: histidine + tryptophan --> histidine + tryptophan ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes for a transporter complex that mediates the exchange of cationic amino acids and neutral amino acids. The documented catalytic activities involve exchanging L-arginine with other amino acids such as L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. The provided reaction, "histidine + tryptophan --> histidine + tryptophan," does not align with any of the catalytic activities associated with the gene. Therefore, based on the gene's annotation, the gene and the reaction are not related. Yes
ENSG00000103064 Q92536 MAR05964: histidine + leucine --> histidine + leucine ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The annotated gene ENSG00000103064 encodes a protein that primarily functions as an antiporter, exchanging L-arginine with other amino acids such as L-leucine, L-glutamine, L-lysine, L-histidine, L-cysteine, and L-methionine, typically in the presence of sodium ions. The documented catalytic activities do not include the direct involvement in a reaction that converts histidine and leucine into histidine and leucine. Therefore, the specific reaction detailed is not related to the gene's known functions or catalytic activities. Yes
ENSG00000021488 P82251 MAR05970: histidine + isoleucine --> histidine + isoleucine ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 encodes a transporter that specifically mediates the exchange of cationic and neutral amino acids, such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine, as stated in the catalytic activity annotations. However, the reaction provided involves histidine and isoleucine, which is not one of the substrates documented in the gene's function or catalytic activities. Therefore, based on the annotations, the gene is not related to the specified reaction. Yes
ENSG00000021488 P82251 MAR05971: citrulline + glycine --> citrulline + glycine ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000021488 functions by forming a transporter complex that mediates the exchange between cationic amino acids and neutral amino acids, specifically facilitating the transport of various amino acids such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine through electrogenic exchange. However, the provided reaction, which involves the transformation of citrulline and glycine into citrulline and glycine, does not involve cationic or neutral amino acid exchange or the specific transport activities described for the gene ENSG00000021488. Therefore, the gene is not relevant to the provided reaction. No
ENSG00000021488 P82251 MAR05974: citrulline + serine --> citrulline + serine ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000021488 encodes a transporter that mediates the electrogenic exchange between cationic and neutral amino acids, such as L-arginine, L-leucine, L-histidine, L-phenylalanine, L-cysteine, L-cystine, and L-lysine. However, the reaction citrulline + serine --> citrulline + serine does not involve any of these substrates or the type of exchange activity associated with the gene. Therefore, based on the function and catalytic activities annotated for the gene, it is not relevant to the specified reaction. No
ENSG00000103064 Q92536 MAR05974: citrulline + serine --> citrulline + serine ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes for a protein that functions primarily as an antiporter involved in the exchange of amino acids such as L-arginine with other amino acids like L-leucine, L-lysine, L-glutamine, and several others. This gene's function involves various catalytic activities related to amino acid transport, which are all different from the reaction mentioned (citrulline + serine --> citrulline + serine). The reaction provided does not involve the amino acid exchanges or transport functions associated with this gene, thus making the gene irrelevant to the specified reaction. No
ENSG00000103064 Q92536 MAR05977: citrulline + phenylalanine --> citrulline + phenylalanine ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an antiporter, specifically involved in the exchange of cationic amino acids (such as L-arginine) with neutral amino acids (like L-leucine, L-glutamine, and others), often in conjunction with sodium ions. Its annotated catalytic activities involve the exchange of L-arginine with various other amino acids or sodium, but it does not mention or imply any role in the reaction between citrulline and phenylalanine. Therefore, there is no evidence linking the gene ENSG00000103064 to the reaction citrulline + phenylalanine ¡ú citrulline + phenylalanine. No
ENSG00000103064 Q92536 MAR05979: citrulline + cysteine --> citrulline + cysteine ENSG00000021488 and ENSG00000103064 and ENSG00000138079 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000103064 encodes a protein that functions as an amino acid transporter, involved in the exchange of L-arginine with various amino acids such as L-leucine, L-glutamine, L-lysine, and others, often in a sodium-dependent manner. The reaction provided, "citrulline + cysteine --> citrulline + cysteine," does not involve any of the transport activities or amino acid exchanges mentioned for this gene. Therefore, the gene does not participate in or relate to the given reaction. No
ENSG00000108932 O15403 MAR05998: H+ + L-lactate <=> H+ + L-lactate ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108932 encodes a monocarboxylate transporter selective for taurine, facilitating its transport across the plasma membrane. This activity is pH- and sodium-independent and focuses on taurine movement. However, the given reaction involves the exchange of hydrogen ion (H+) and L-lactate, which is unrelated to taurine. Therefore, the gene's function does not correspond to the reaction provided. No
ENSG00000141526 O15427 MAR06003: acetoacetate + propanoate <=> acetoacetate + propanoate ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 is annotated to function as a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate. It is involved in L-lactate efflux and has catalytic activities specific to the transport of (S)-lactate and pyruvate along with protons. The reaction provided involves acetoacetate and propanoate, which are not related to the substrates or products transported by the gene ENSG00000141526. Therefore, the gene and the reaction are not related. No
ENSG00000108932 O15403 MAR06004: acetoacetate + L-lactate <=> acetoacetate + L-lactate ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190 Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes a monocarboxylate transporter specific for taurine, which facilitates the efflux or influx of taurine across the plasma membrane. The transporter function described is specific to taurine transport and is pH- and sodium-independent. However, the reaction provided involves the interconversion of acetoacetate and L-lactate, which is unrelated to taurine transport. Therefore, the gene product does not catalyze the reaction involving acetoacetate and L-lactate. No