ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a proton-dependent transporter involved in the transport of monocarboxylates, primarily L-lactate and pyruvate. Its functions include the efflux of L-lactate and the bidirectional transport of pyruvate in exchange for protons, as described in the annotated catalytic activities. However, the reaction provided (acetoacetate + L-lactate <=> acetoacetate + L-lactate) does not involve the transport of L-lactate or pyruvate across a membrane or involve proton exchange, which are the key functions of the encoded protein. Therefore, the gene ENSG00000141526 is not related to the provided reaction.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000155380 encodes a bidirectional proton-coupled monocarboxylate transporter (MCT1) that facilitates the transport of various monocarboxylates such as lactate, pyruvate, acetate, acetoacetate, and beta-hydroxybutyrate across the plasma membrane. The provided reaction, "acetoacetate + retinoate <=> acetoacetate + retinoate," does not involve the transport of any substrate across membranes or the involvement of protons in a manner described by the function and catalytic activities of MCT1. The gene's function is specifically related to proton-coupled monocarboxylate transport, whereas the reaction involves retinoate, which is not a monocarboxylate or related to the transport processes facilitated by MCT1.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000100156 encodes a protein that is a probable proton-coupled L-lactate transporter specific to the retinal pigment epithelium. Its function involves the transport of lactate and protons to help maintain pH and ion homeostasis in the retina. The catalytic activity described for this gene involves the movement of L-lactate and H+ ions in and out of the retina. However, the provided reaction involves 2-hydroxybutyrate and acetoacetate, which are not related to the gene¡¯s function or catalytic activity, indicating no connection between the gene and this specific reaction.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a protein that functions as a proton-dependent transporter for monocarboxylates, specifically L-lactate and pyruvate. It facilitates the efflux of L-lactate from glycolytic cells and the transport of pyruvate across membranes, as supported by multiple publications. The reactions it catalyzes involve the transport of these specific monocarboxylates in association with protons. However, the reaction provided involves the interconversion of 2-hydroxybutyrate and acetoacetate, which are not substrates handled by the transporter protein associated with the gene ENSG00000141526. Therefore, the gene is not relevant to the provided reaction.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000100156 is involved in the transport of (S)-lactate and H(+) ions across the retinal pigment epithelium, as evidenced by its catalytic activity. The reaction stated, involving 2-hydroxybutyrate and formate, does not correspond to the lactate transport function of the gene. Therefore, the gene and the reaction are not related.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 is annotated to code for a monocarboxylate transporter selective for taurine, mediating its transport across the plasma membrane. The catalytic activity described pertains to the transport of taurine, not to the chemical reaction involving 2-hydroxybutyrate and propanoate. Therefore, the gene does not have a functional role in the provided reaction.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate, which functions predominantly in the efflux of L-lactate from highly glycolytic cells. Its catalytic activities involve the transport of (S)-lactate and pyruvate across the cell membrane in the presence of protons. However, the provided reaction, "2-hydroxybutyrate + butyrate <=> 2-hydroxybutyrate + butyrate," does not involve the substrates (L-lactate or pyruvate) or the type of transport activity described for this gene. Therefore, there is no direct relationship between the gene and the provided reaction.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000118596 encodes for a proton-coupled monocarboxylate symporter involved in the transport of monocarboxylates like L-lactate, pyruvate, and ketone bodies across the plasma membrane. The reactions catalyzed by this symporter involve the transport of monocarboxylates coupled with protons. However, the reaction given, "2-hydroxybutyrate + retinoate <=> 2-hydroxybutyrate + retinoate," does not involve monocarboxylates nor proton coupling and thus is not related to the gene's function.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000100156 encodes a protein that functions as a proton-coupled L-lactate transporter involved in the transport of lactate and hydrogen ions in the retina. The annotated catalytic activity of this gene is the transport of (S)-lactate and H(+) across cell membranes. However, the reaction provided (acetate + pyruvate <=> acetate + pyruvate) does not involve L-lactate or hydrogen ions and does not match the function or catalytic activity of the gene product. Therefore, the gene is not related to the given reaction.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes for a monocarboxylate transporter selective for taurine, mediating its transport across the plasma membrane. The annotated catalytic activity specifically involves the transport of taurine, which is distinct from the reaction provided that involves pyruvate and retinoate. Therefore, the gene's function and catalytic activity do not relate to the reaction involving pyruvate and retinoate.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: Based on the annotation, the gene ENSG00000108932 encodes a monocarboxylate transporter selective for taurine and mediates taurine transport across the plasma membrane. The catalyzed reaction involves the movement of taurine, whereas the reaction provided (AKG + formate <=> AKG + formate) is unrelated to taurine transport and does not match the function or catalytic activity of the gene product.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes a monocarboxylate transporter specific for taurine, mediating its efflux and influx across the plasma membrane in a pH- and sodium-independent manner. The associated catalytic activity involves the transport of taurine but does not involve the reaction AKG + butyrate <=> AKG + butyrate. Thus, the gene and the provided reaction are not related.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The function of the gene ENSG00000100156 is to act as a probable retinal pigment epithelium-specific proton-coupled L-lactate transporter, which facilitates the transport of lactate and H(+) for pH and ion homeostasis in the retina. The catalytic activity described involves the transport of (S)-lactate and H(+), unrelated to the reaction involving AKG and retinoate. Therefore, the gene does not relate to the given reaction.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000118596 encodes a proton-coupled monocarboxylate symporter that catalyzes the transport of monocarboxylates like L-lactate, pyruvate, and ketone bodies across the plasma membrane. The specific catalytic activities mentioned involve substrates such as pyruvate, L-lactate, acetoacetate, and related compounds. However, the provided reaction "formate + propanoate <=> formate + propanoate" does not involve any of these substances nor does it describe a proton-coupled transport mechanism, making it unrelated to the described function of the gene.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000100156 encodes a protein that is a probable retinal pigment epithelium (RPE)-specific proton-coupled L-lactate transporter. Its function involves facilitating the transport of lactate and protons (H+) out of the retina, contributing to the pH and ion homeostasis of the outer retina. The catalytic activity associated with this gene involves the transport of (S)-lactate and H+ ions across membranes. In contrast, the reaction provided involves butyrate and formate, which is unrelated to the gene's annotated catalytic activity and function. Therefore, the gene and the reaction are not related.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000100156 is implicated in the transport of lactate and proton (H+), playing a role in pH and ion homeostasis in the retina, as evidenced by its catalytic activity involving the transport of (S)-lactate and H+. However, the reaction described involves the interchange of formate and retinoate, which is unrelated to the gene's function in lactate and proton transport.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The function of the gene ENSG00000118596 involves the transport of monocarboxylates such as L-lactate, pyruvate, and ketone bodies across the plasma membrane via proton-coupling. The listed catalytic activities describe reactions specifically involving the transport of various monocarboxylates and hydrogen ions. However, the reaction provided, "propanoate + retinoate <=> propanoate + retinoate", does not involve the transport of monocarboxylates or hydrogen ions and is not related to the catalytic activities performed by the gene. Therefore, the gene is not relevant to the reaction provided.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000100156 encodes a probable retinal pigment epithelium-specific proton-coupled L-lactate transporter, which is involved in the transport of L-lactate and H+ out of the retina. The provided reaction involves the interchange of (R)-3-hydroxybutanoate and propanoate, which does not align with the gene's annotated catalytic activity of transporting L-lactate and H+. Therefore, the gene and the reaction are not related.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000108932 encodes a monocarboxylate transporter that is specific for taurine, facilitating its transport across the plasma membrane. The annotated reactions involve taurine transport (taurine(out) = taurine(in)), while the provided reaction (acetoacetate + butyrate <=> acetoacetate + butyrate) involves the exchange between acetoacetate and butyrate, which is unrelated to taurine transport.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000155380 encodes a protein that functions primarily as a bidirectional proton-coupled monocarboxylate transporter, facilitating the transport of several monocarboxylates across the plasma membrane. The transport activities include lactate, pyruvate, acetate, acetoacetate, beta-hydroxybutyrate, succinate, 3-methyl-2-oxobutanoate, and 4-methyl-2-oxopentanoate, in association with protons. The reaction given, (R)-3-hydroxybutanoate + butyrate <=> (R)-3-hydroxybutanoate + butyrate, does not fall under the catalytic activities or physiological transport functions documented for this gene product. Hence, there is no relevant link between the gene's annotated functions and the provided reaction.
ENSG00000039123 or ENSG00000054148 or ENSG00000063601 or ENSG00000067113 or ENSG00000072756 or ENSG00000087053 or ENSG00000126821 or ENSG00000139505 or ENSG00000141934 or ENSG00000162407 or ENSG00000163082
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000126821 encodes an enzyme that specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P, but does not act on FAD, ceramide 1-phosphate, lysophosphatidic acid, or phosphatidic acid. The catalytic activities described for this gene involve the conversion of sphinganine 1-phosphate and sphing-4-enine 1-phosphate into their respective sphingoid bases and phosphates. In contrast, the reaction provided involves FAD, which is not a substrate of the enzyme encoded by this gene.
MAR07499: chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan --> chondroitin sulfate A (GalNAc4S-GlcA) proteoglycan
ENSG00000174669
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000174669 is involved in the transport of nucleosides and nucleobases, occurring as a bidirectional uniporter responsible for the facilitative transport of various nucleosides such as inosine, adenosine, uridine, thymidine, cytidine, and guanosine, as well as nucleobases including hypoxanthine, adenine, guanine, thymine, and uracil. The reaction described involves chondroitin sulfate A proteoglycans, which are not related to the transport functions or substrates of the gene ENSG00000174669, which deals strictly with nucleosides and nucleobases.
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000196517 encodes a sodium- and chloride-dependent glycine transporter, and its annotated catalytic activities involve transporting glycine along with chloride and sodium ions. However, the reaction provided involves lysine, not glycine, which is outside the functional scope of the glycine transporter described for the gene.
ENSG00000012660 or ENSG00000026652 or ENSG00000100344 or ENSG00000102125 or ENSG00000111684 or ENSG00000123684 or ENSG00000125505 or ENSG00000141446 or ENSG00000143797 or ENSG00000146648 or ENSG00000151093 or ENSG00000160216 or ENSG00000169359 or ENSG00000170522 or ENSG00000171320 or ENSG00000176454 or ENSG00000186792 or ENSG00000197977
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141446 encodes an acetyltransferase that is involved in the establishment of sister chromatid cohesion through the acetylation of the cohesin component SMC3. The catalytic activity described involves the acetylation of lysine residues on proteins, which is different from the reaction involving butyryl-CoA and L-carnitine. Therefore, the gene's function and catalytic activity are not related to the provided reaction.
ENSG00000012660 or ENSG00000026652 or ENSG00000100344 or ENSG00000102125 or ENSG00000111684 or ENSG00000123684 or ENSG00000125505 or ENSG00000141446 or ENSG00000143797 or ENSG00000146648 or ENSG00000151093 or ENSG00000160216 or ENSG00000169359 or ENSG00000170522 or ENSG00000171320 or ENSG00000176454 or ENSG00000186792 or ENSG00000197977
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000160216 encodes for an enzyme that is involved in the conversion of lysophosphatidic acid (LPA) into phosphatidic acid (PA) by incorporating acyl moieties at the sn-2 position of the glycerol backbone. It acts on various lysophospholipids using specific acyl-CoAs as donors. However, the reaction provided involves butyryl-CoA and L-carnitine, which is not related to the enzymatic functions or substrates described for the gene ENSG00000160216. Thus, the gene and the reaction are not related.
ENSG00000012660 or ENSG00000026652 or ENSG00000100344 or ENSG00000102125 or ENSG00000111684 or ENSG00000123684 or ENSG00000125505 or ENSG00000141446 or ENSG00000143797 or ENSG00000146648 or ENSG00000151093 or ENSG00000160216 or ENSG00000169359 or ENSG00000170522 or ENSG00000171320 or ENSG00000176454 or ENSG00000186792 or ENSG00000197977
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000012660 is involved in catalyzing the elongation of very-long-chain fatty acids through several specific catalytic activities involving CoA derivatives and malonyl-CoA as substrates. However, the reaction provided, "butyryl-CoA + L-carnitine <=> butyryl-CoA + L-carnitine," does not involve these substrates or products, nor does it pertain to the fatty acid elongation cycle. Therefore, there is no connection between the gene function and the provided reaction.
ENSG00000100156 or ENSG00000108932 or ENSG00000118596 or ENSG00000141526 or ENSG00000155380 or ENSG00000168679 or ENSG00000170190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000141526 encodes a proton-dependent transporter that primarily facilitates the transport of monocarboxylates such as L-lactate and pyruvate. The reactions catalyzed by this transporter involve the movement of lactate and pyruvate across membranes in a proton-dependent manner, as evidenced by multiple publications. However, the reaction provided involves the conversion of 2-oxobutyrate and a proton to the same products, which does not align with the transport functions described for the gene. Therefore, the gene does not have a direct role in the given reaction.
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 encodes a mitochondrial transporter responsible for the uptake of thiamine diphosphate into mitochondria, with its specific catalytic activity involving the exchange of thiamine diphosphate and thiamine phosphate. However, the reaction provided (ATP + dATP --> ATP + dATP) does not involve thiamine diphosphate or thiamine phosphate and thus is unrelated to the function of the gene.
MAR06389: Pi + sn-glycerol-3-phosphate --> Pi + sn-glycerol-3-phosphate
ENSG00000160190
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000160190 encodes an inorganic phosphate and glucose-6-phosphate antiporter, which transports glucose-6-phosphate and inorganic phosphate across the endoplasmic reticulum membrane. However, the reaction provided involves the interconversion of inorganic phosphate (Pi) and sn-glycerol-3-phosphate, which does not involve glucose-6-phosphate. Therefore, the function and catalytic activity of the gene do not match the provided reaction.
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000125454 encodes a mitochondrial transporter that mediates the uptake of thiamine diphosphate into mitochondria, and its catalytic activity involves the exchange of thiamine diphosphate and thiamine phosphate. However, the reaction described (dADP + dUTP --> dADP + dUTP) is unrelated to thiamine metabolism and involves nucleotide diphosphates, indicating that the gene does not play a role in this reaction.
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000125454 encodes a mitochondrial transporter mediating the uptake of thiamine diphosphate into mitochondria, facilitating a specific antiporter reaction involving thiamine diphosphate and thiamine phosphate. However, the reaction dATP + dTDP --> dATP + dTDP does not involve any substrates or products related to thiamine diphosphate or thiamine phosphate, indicating that the function of the gene is unrelated to the reaction provided.
MAR03008: ATP + H2O + propanoyl-CoA --> ADP + H+ + Pi + propanoyl-CoA
ENSG00000067829 or ENSG00000067840 or ENSG00000101986 or ENSG00000130821 or ENSG00000130822 or ENSG00000184343 or ENSG00000185825
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000130822 encodes a calcium/calmodulin-dependent protein kinase that phosphorylates proteins such as CREB1 and SYN1/synapsin I. The catalytic activities mentioned involve phosphorylation of L-seryl and L-threonyl residues on proteins using ATP. However, the provided reaction involves the hydrolysis of ATP with propanoyl-CoA, which does not align with the kinase activity of the protein encoded by the gene. Therefore, the gene and the provided reaction are not related.
MAR03017: (13Z)-eicosenoyl-CoA + ATP + H2O --> (13Z)-eicosenoyl-CoA + ADP + H+ + Pi
ENSG00000067829 or ENSG00000067840 or ENSG00000101986 or ENSG00000130821 or ENSG00000130822 or ENSG00000184343 or ENSG00000185825
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000184343 encodes a serine/arginine-rich protein-specific kinase which phosphorylates its substrates at serine and threonine residues in RS domains, a process involved in muscle development and splicing factor phosphorylation. However, the reaction (13Z)-eicosenoyl-CoA + ATP + H2O --> (13Z)-eicosenoyl-CoA + ADP + H+ + Pi describes the hydrolysis of ATP which is unrelated to the phosphorylation of serine or threonine residues in RS domains, indicating no connection between the gene function and the reaction.
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000123643's function involves electrogenic proton/amino acid symport, specifically for small apolar L-amino acids, their D-enantiomers, and certain amino acid derivatives, facilitating their movement across membranes. The catalytic activities described include transport of multiple amino acids (e.g., glycine, L-alanine, D-alanine, L-proline, D-proline, D-serine, L-serine, 4-aminobutanoate/GABA, and beta-alanine) across the membrane coupled with proton movement. However, the reaction "methionine --> methionine" does not involve any transportation process or changes in amino acid states that align with the gene¡¯s annotated functions. Thus, the gene is not relevant to the described reaction.
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000123643 encodes for a protein that functions as an electrogenic proton/amino acid symporter involved in the transport of various amino acids and their derivatives. This includes catalytic activities for glycine, L-alanine, D-alanine, L-proline, D-proline, D-serine, L-serine, 4-aminobutanoate, and beta-alanine. However, the provided reaction is a transformation of threonine to threonine, which does not involve any transport activity and is not related to the symporter functions described for the gene. Therefore, the gene does not have any relevance to the provided reaction.
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000197818 encodes for a Na(+)/H(+) antiporter which mediates the exchange of H(+) ions for Na(+) ions. However, the reaction provided involves the exchange of H+ and K+ ions, which does not align with the Na(+)/H(+) exchange function of the gene product. Therefore, based on the gene¡¯s function and the specific ions involved, the gene and the reaction are not related.
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000088386 encodes for an electrogenic proton-coupled amino-acid transporter responsible for the transmembrane transport of di- and tripeptides in combination with protons (H+). The reactions catalyzed by this gene involve the movement of various oligopeptides across membranes, as indicated by the specific substrate examples and literature references (PubMed). However, the reaction provided (H+ + D-alanyl-D-alanine --> H+ + D-alanyl-D-alanine) does not involve any transmembrane transport but rather suggests an equilibrium reaction not aligned with the known catalytic activities of the encoded transporter. Therefore, the gene is not relevant to the reaction provided.
MAR06864: ascorbate + ATP + H2O + 2.0 Na+ --> ADP + ascorbate + H+ + 2.0 Na+ + Pi
ENSG00000089057 or ENSG00000170482
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000170482 encodes a sodium:ascorbate cotransporter protein, which mediates the uptake of vitamin C and urate with sodium ions. The reactions catalyzed by this transporter involve the movement of ascorbate and urate across the cell membrane in exchange for sodium ions. However, the provided reaction describes ascorbate interacting with ATP, water, sodium ions, producing ADP, ascorbate, hydrogen ions, sodium ions, and inorganic phosphate. This reaction includes the hydrolysis of ATP, which is not a function of the sodium:ascorbate cotransporter. Therefore, the gene and the provided reaction are unrelated.
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000115902 encodes a sodium-dependent neutral amino-acid transporter that mediates the transport of specific amino acids¡ªnamely alanine, serine, cysteine, proline, hydroxyproline, and threonine¡ªacross the cell membrane. The reactions catalyzed by this transporter involve the exchange of these amino acids with sodium ions. However, the reaction provided (aspartate + Na+ + proline --> aspartate + Na+ + proline) does not pertain to the transport activities listed for the gene. The annotated functions and catalytic activities do not include aspartate, indicating that the gene does not facilitate the transport of aspartate, thus making it irrelevant to the given reaction.
ENSG00000137204 or ENSG00000149452 or ENSG00000168065
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000168065 functions as an antiporter mediating the transport of conjugated steroids, organic anions, prostaglandins, and some anionic drugs, but does not mention any activity involving folate or sulfate exchange, which is the reaction provided. Hence, the gene's annotated transport activities are unrelated to the specific reaction described.
MAR10155: 5beta-cholestane-3alpha,7alpha,12alpha,24s,25-pentol + ATP + H2O --> 5beta-cholestane-3alpha,7alpha,12alpha,24s,25-pentol + ADP + H+ + Pi
ENSG00000073734 or ENSG00000108846 or ENSG00000121270
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000121270 encodes an ATP-dependent transporter of the ATP-binding cassette (ABC) family that is involved in the active efflux of a wide variety of physiological compounds and xenobiotics, including bile acids, steroid sulfates, cyclic nucleotides, and various other substrates. The reactions it catalyzes typically involve the hydrolysis of ATP to provide the energy for transporting these compounds out of cells. However, the provided reaction involves 5beta-cholestane-3alpha,7alpha,12alpha,24s,25-pentol and does not align with any of the substrates or processes described in the gene's functions and catalytic activities, indicating that this gene does not mediate this specific reaction.
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000123643 encodes a protein that functions as an electrogenic proton/amino acid symporter specifically targeting small apolar L-amino acids, their D-enantiomers, and certain amino acid derivatives such as GABA. It facilitates the transport of these molecules across cellular compartments. The described reaction involving 5-aminolevulinate and a proton does not correspond to any of the catalytic activities or specific substrates listed for the enzyme associated with ENSG00000123643, indicating no direct relevance or involvement in this reaction.
Yes, 5-aminolevulinate belongs to a amino acid derivative.
MAR11380: 5beta-cholestane-3alpha,7alpha,26-triol + ATP + H2O --> 5beta-cholestane-3alpha,7alpha,26-triol + ADP + H+ + Pi
ENSG00000073734 or ENSG00000108846 or ENSG00000121270
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation: The gene ENSG00000108846 encodes an ATP-dependent transporter that facilitates the transport of various substrates, including drugs, toxicants, and endogenous compounds, across cell membranes by binding and hydrolyzing ATP. The gene-associated catalytic activities involve the transport of glucuronide conjugates, bile salts, S-substituted glutathione, xenobiotics, estradiol glucuronide, dehydroepiandrosterone sulfate, leukotriene C4, and bilirubin glucuronoside. The specific reaction provided (5beta-cholestane-3alpha,7alpha,26-triol + ATP + H2O --> 5beta-cholestane-3alpha,7alpha,26-triol + ADP + H+ + Pi) does not involve the transport activities or substrates mentioned for the gene product. Therefore, the gene is not relevant to the reaction provided.
ENSG00000111700 or ENSG00000134538 or ENSG00000163959 or ENSG00000186198
Pending No, the gene is not relevant to the reaction provided. Analysis and explanation. The gene ENSG00000163959 functions as part of the Ost-alpha/Ost-beta complex, which is involved in the transport of bile acids, steroids, eicosanoids, and other specific molecules across the basolateral membrane. The gene catalyzes multiple reactions involving various compounds such as taurocholate, estrone 3-sulfate, and prostaglandin E2. However, the reaction HCO3- + Coprostanol <=> HCO3- + Coprostanol does not involve any of the substrates or products associated with the catalytic activities of the gene. Therefore, the gene and the reaction are not related based on the provided annotation.
Current behavior:
44 genes are discovered to be uncorrelated with their corresponding reactions in Transport reactions.