Closed edkerk closed 1 year ago
I reorganized the curation code and data files (and will write clearer instructions for future curations), correct some identifiers and made some further modifications.
Two open questions:
[ ] There are 2-methylbutyrate and isobutyrate assigned to the extracellular compartment, but there is no transport reaction across the cytoplasmic membrane, nor an exchange reaction that would allow for its net production. Is this intentional, or should such reactions be added?
[ ] I now assigned the volatile ester reactions to the subsystem "Other", is there another one from this list that is more suitable?
Alanine, aspartate and glutamate metabolism
Alternate carbon metabolism
Amino sugar and nucleotide sugar metabolism
Arachidonic acid metabolism
Arginine and proline metabolism
Arginine biosynthesis
Ascorbate and aldarate metabolism
Ascospore biosynthesis
Beta-alanine metabolism
Biosynthesis of unsaturated fatty acids
Biotin metabolism
Butanoate metabolism
C5-branched dibasic acid metabolism
Carnitine metabolism
Cellular response to anaerobic conditions
Citrate cycle (TCA cycle)
Complex alcohol metabolism
Cyclic nucleotide metabolism
Cysteine and methionine metabolism
DNA repair
Dipeptidases
Exchange reaction
Fatty acid biosynthesis
Fatty acid degradation
Fatty acid ester pathway
Folate biosynthesis
Fructose and mannose metabolism
Galactose metabolism
Glutathione metabolism
Glycerolipid metabolism
Glycerophospholipid metabolism
Glycine, serine and threonine metabolism
Glycolysis / gluconeogenesis
Glycosylphosphatidylinositol (gpi)-anchor biosynthesis
Glyoxylate and dicarboxylate metabolism
Growth
Histidine metabolism
Inositol phosphate metabolism
Insect hormone biosynthesis
Lipoic acid metabolism
Lysine metabolism
Methylglyoxal metabolism
N-glycan biosynthesis
Nicotinate and nicotinamide metabolism
Nitrogen metabolism
One carbon pool by folate
Other
Oxidative phosphorylation
Pantothenate and coa biosynthesis
Pentose and glucuronate interconversions
Pentose phosphate pathway
Peptidyl-diphthamide biosynthetic process
Phenylalanine metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Phosphatidylinositol signaling system
Porphyrin and chlorophyll metabolism
Propanoate metabolism
Purine metabolism
Pyrimidine metabolism
Pyruvate metabolism
Riboflavin metabolism
SLIME reaction
Sphingoglycolipid metabolism
Sphingolipid metabolism
Starch and sucrose metabolism
Steroid biosynthesis
Sulfur metabolism
Superoxide metabolism
Taurine and hypotaurine metabolism
Terpenoid backbone biosynthesis
Thiamine metabolism
Threonylcarbamoyladenosine metabolism
Transport [c, ce]
Transport [c, e]
Transport [c, er]
Transport [c, erm]
Transport [c, g]
Transport [c, gm]
Transport [c, lp]
Transport [c, m]
Transport [c, mm]
Transport [c, n]
Transport [c, p]
Transport [c, v]
Transport [c, vm]
Transport [ce, erm]
Transport [e, ce]
Transport [er, g]
Transport [erm, er]
Transport [erm, gm]
Transport [erm, lp]
Transport [erm, mm]
Transport [erm, n]
Transport [erm, vm]
Transport [m, mm]
Transport [m, v]
Transport [p, m]
Transport [vm, ce]
Transport [vm, gm]
Transport[c, e]
Tryptophan metabolism
Tyrosine metabolism
Ubiquinone and other terpenoid-quinone biosynthesis
Valine, leucine and isoleucine metabolism
Vitamin b6 metabolism
tRNA metabolism
thanks a lot for the improvements and adaptations!
2-methylbutyrate and isobutyrate need no extracellular association. They suffice as cytoplasmic intermediates for the ester synthesis.
The volatile ester reactions fit better to the subsystem 'Fatty acid ester pathway' than 'Other'
On 04/06/2023 22:21, Eduard Kerkhoven wrote:
I reorganized the curation code and data files (and will write clearer instructions for future curations), correct some identifiers and made some further modifications.
Two open questions:
- There are 2-methylbutyrate and isobutyrate assigned to the extracellular compartment, but there is no transport reaction across the cytoplasmic membrane, nor an exchange reaction that would allow for its net production. Is this intentional, or should such reactions be added?
- I now assigned the volatile ester reactions to the subsystem "Other", is there another one from this list that is more suitable?
Click to show list of subsystems
- Alanine, aspartate and glutamate metabolism
- Alternate carbon metabolism
- Amino sugar and nucleotide sugar metabolism
- Arachidonic acid metabolism
- Arginine and proline metabolism
- Arginine biosynthesis
- Ascorbate and aldarate metabolism
- Ascospore biosynthesis
- Beta-alanine metabolism
- Biosynthesis of unsaturated fatty acids
- Biotin metabolism
- Butanoate metabolism
- C5-branched dibasic acid metabolism
- Carnitine metabolism
- Cellular response to anaerobic conditions
- Citrate cycle (TCA cycle)
- Complex alcohol metabolism
- Cyclic nucleotide metabolism
- Cysteine and methionine metabolism
- DNA repair
- Dipeptidases
- Exchange reaction
- Fatty acid biosynthesis
- Fatty acid degradation
- Fatty acid ester pathway
- Folate biosynthesis
- Fructose and mannose metabolism
- Galactose metabolism
- Glutathione metabolism
- Glycerolipid metabolism
- Glycerophospholipid metabolism
- Glycine, serine and threonine metabolism
- Glycolysis / gluconeogenesis
- Glycosylphosphatidylinositol (gpi)-anchor biosynthesis
- Glyoxylate and dicarboxylate metabolism
- Growth
- Histidine metabolism
- Inositol phosphate metabolism
- Insect hormone biosynthesis
- Lipoic acid metabolism
- Lysine metabolism
- Methylglyoxal metabolism
- N-glycan biosynthesis
- Nicotinate and nicotinamide metabolism
- Nitrogen metabolism
- One carbon pool by folate
- Other
- Oxidative phosphorylation
- Pantothenate and coa biosynthesis
- Pentose and glucuronate interconversions
- Pentose phosphate pathway
- Peptidyl-diphthamide biosynthetic process
- Phenylalanine metabolism
- Phenylalanine, tyrosine and tryptophan biosynthesis
- Phosphatidylinositol signaling system
- Porphyrin and chlorophyll metabolism
- Propanoate metabolism
- Purine metabolism
- Pyrimidine metabolism
- Pyruvate metabolism
- Riboflavin metabolism
- SLIME reaction
- Sphingoglycolipid metabolism
- Sphingolipid metabolism
- Starch and sucrose metabolism
- Steroid biosynthesis
- Sulfur metabolism
- Superoxide metabolism
- Taurine and hypotaurine metabolism
- Terpenoid backbone biosynthesis
- Thiamine metabolism
- Threonylcarbamoyladenosine metabolism
- Transport [c, ce]
- Transport [c, e]
- Transport [c, er]
- Transport [c, erm]
- Transport [c, g]
- Transport [c, gm]
- Transport [c, lp]
- Transport [c, m]
- Transport [c, mm]
- Transport [c, n]
- Transport [c, p]
- Transport [c, v]
- Transport [c, vm]
- Transport [ce, erm]
- Transport [e, ce]
- Transport [er, g]
- Transport [erm, er]
- Transport [erm, gm]
- Transport [erm, lp]
- Transport [erm, mm]
- Transport [erm, n]
- Transport [erm, vm]
- Transport [m, mm]
- Transport [m, v]
- Transport [p, m]
- Transport [vm, ce]
- Transport [vm, gm]
- Transport[c, e]
- Tryptophan metabolism
- Tyrosine metabolism
- Ubiquinone and other terpenoid-quinone biosynthesis
- Valine, leucine and isoleucine metabolism
- Vitamin b6 metabolism
- tRNA metabolism
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Seeing these new contributions, I'm wondering if yeast-GEM wouldn't also benefit from allcontributors.org setup, see https://github.com/SysBioChalmers/Human-GEM#contributors - what do others think?
@mihai-sysbio I'm not sure why the memote-run
GitHub Action fails, especially as memote-history
succeeds?
Anyway, I've reviewed the changes in this PR (but cannot post a review on my own PR), while the changes were originally committed as #336. I'll therefore force merge without review.
@edkerk thanks for pinging about this. It was a good call to proceed without investigating.
The workflow runs a Python line before running Memote, to make the model Bigg compliant. This is achieved with a file code/io.py
which looks like is missing from this PR but exists in branch develop
. As a one-time workflow failure this is acceptable (although I don't know how this happened), but there shouldn't be failures like this in the future.
This PR replaces #336, as the previous PR does not allow for additional commits by the maintainers (reason). The text below is copy-pasted from #336, authored by @uliebal.
Main improvements in this PR:
Addition of in total 1 gene.
Volatile esters
Polyphosphate reactions
Developers
I hereby confirm that I have:
develop
as a target branch (top left drop-down menu)