Closed hongzhonglu closed 6 years ago
Excellent. RAVEN 2.0 also supports confidenceScores as a field.
@hongzhonglu I like the idea! How did you come up with the score system? Something that is not clear to me is if the confidence scores are cumulative, e.g. what happens if we have genetic data but no physiological data?
@hongzhonglu, to my knowledge COBRA 3 developers now re-scaled confidence score system from 0 (worst) to 5 (the highest). So I suggest that we incorporate confidence scores compliant with COBRA 3 as well. I got such information from [COBRA directory]/docs/source/notes/COBRA_structure_fields.xlsx.
@simas232 Good! @BenjaSanchez The original scores system is from "A protocol for generating a high-quality genome-scale metabolic reconstruction". For “ what happens if we have genetic data but no physiological data?”, The genetic data can be more valuable, so it can be 3 even there are no physiological data ?
@simas232 Do you find how to define 0-5 for reactions? I only find the definitions in the above table.
@hongzhonglu, no I didn't find the definitions for the new grade scale. The COBRA 3.0 manuscript is available online, but they didn't include the table with descriptions.
@simas232, Thanks! I also checked the scores in latest E.coli model. Also 4 is highest scores for all reactions. So let us just use the score system in above table.
the confidence scores have been added in commit f787058
using an automatic function. Some manual curation remains, but for now this issue will be closed
Based on the confidence scores of reactions, we can add scores for reactions yeast model.
Based on the confidence scores, it can be more clear for us to improve the model quality consistently, how do you think of it ? @all.