Open Feat-FeAR opened 3 months ago
Importantly, this really happens even within the restricted geneset of ion channels, as of org.Hs.eg.db
v.3.18.0 (Bioconductor version 3.18 - BiocManager 1.30.23):
KCNMB2
ENSG00000197584 KCNMB2 potassium calcium-activated channel subfamily M regulatory beta subunit 2
ENSG00000275163 KCNMB2 potassium calcium-activated channel subfamily M regulatory beta subunit 2
AQP12
ENSG00000184945 AQP12A aquaporin 12A protein-coding
ENSG00000185176 AQP12A,AQP12B aquaporin 12A,aquaporin 12B protein-coding
In
subsetGenes.xSeries
, when, for a given key value (e.g., gene symbol), more than one occurrence is found in the annotation table of the xSeries (i.e., the same duplicated SYMBOL for multiple ENSG IDs) no action is taken and each entry is assigned to a different bar in the final chart, even if its name is not unique. It should be better to provide a rule to collapse statistics of genes with the same key value (e.g., keeping only the most expressed or their sum...), provided that user's "subsetting intention" is based on geneset key, rather than on (unique) ENSG IDs... See the same problem in GOZER