In-silico method written in Python and R to determine HLA genotypes of a sample. seq2HLA takes standard RNA-Seq sequence reads in fastq format as input, uses a bowtie index comprising all HLA alleles and outputs the most likely HLA class I and class II genotypes (in 4 digit resolution), a p-value for each call, and the expression of each class.
I am currently analyzing the seq2HLA outputs, and I have a question about the definition of the confidence scores. Are they equal to Pvalues or 1 - Pvalues? Is this value the higher the better?
Hi,
I am currently analyzing the seq2HLA outputs, and I have a question about the definition of the confidence scores. Are they equal to Pvalues or 1 - Pvalues? Is this value the higher the better?
I really appreciate your help!!
Yuan