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TangSoftwareLab / SynergyFinderR

SynergyFinder R package development
https://www.bioconductor.org/packages/release/bioc/html/synergyfinder.html
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Question regarding SynergyFinder R package #5

Open ernieiraniliu opened 1 year ago

ernieiraniliu commented 1 year ago

Hi, I am recently using the synergyfinder package to calculate Loewe synergy scores for a set of data. I have been facing this issue recently and hope you can assist me. I have noticed that when using reshape data and CalculateSynergy functions of the package, respectively, to calculate synergy scores, I get very different outputs when inputting data with different numbers of blocks. For example, if I enter data with only block 1, the synergy score output is different with, say, data with blocks 1 to 10. From my understanding, there should be no connection between different blocks as they each identify different drug combination response data on different cell lines. Thus, I am confused about why the synergy score of a block would depend on other blocks. Furthermore, the same situation occurs with the online tool http://www.synergyfinder.org/ .

shuyuzheng commented 1 year ago

Hi, thank you for report. I have tested this issue on the latest version (V3.6.2) of R package and web app (http://www.synergyfinder.org/). It seems this issue has been solved. If it is still there, please let me know.