search

Teichlab / cellphonedb

MIT License
340 stars 105 forks source link

question for results file #192

Closed MMriran closed 3 years ago

MMriran commented 4 years ago

Hi, Thank you for your great tools！ I had a question for results files. What is the numerical value means in "means.txt"?（means.txt） Thank you!

Daliya-K commented 4 years ago

According to the documentation: the mean values in the "means.txt" output refers to the total mean of the individual partner average expression values in the corresponding interacting pairs of cell types. If one of the mean values is 0, then the total mean is set to 0.

MMriran commented 4 years ago

Thank you for your reply. So is the numerical value in "means.txt" stand for the strength of interactions between cells? And what files （means.txt? or significant means.txt） should I used to draw a cell-cell communications？

mief commented 3 years ago

Hi, The means file shows the mean of the average receptor and average ligand expression level in the corresponding clusters. Or if you have a column X|Y for a specific interaction R1-L1, then the mean would be mean(mean(R1 in cluster X), mean(L1 in cluster Y)). The significant means table shows the means of only the significant interactions, and all others are set to 0. If you want to draw the significant interactions, you should use the significant means file.