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Teichlab / cellphonedb

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ligand_receptor or receptor_ligand? #265

Closed chrsyl closed 3 years ago

chrsyl commented 3 years ago

While ligand_receptor annotation is the norm, why does cellphonedb also annotate as receptor_ligand? For example if I plot celltype A|celltype B & celltype B|celltype A, there can be FLT1_VEGFB for A|B BUT NOT VEGFB_FLT1 FOR B|A.

luzgaral commented 3 years ago

CellphoneDB also includes other cell-cell interactions other than Ligand/Receptors, such as integrins, which do not have a direction in the signalling. That is why the order (ligand_receptor or receptor_ligand) is ignored.

Hope it makes sense.