edit definition for "insulator"

The-Sequence-Ontology / SO-Ontologies

Collect of SO Ontologies

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edit definition for "insulator" #311

Open srynobio opened 9 years ago

srynobio commented 9 years ago

proposed definition: A transcriptional cis regulatory region (ranges from 0.5kb to 3kbp) that when located between an enhancer and a promoter, the insulator prevents the enhancer from modulating expression of that gene.

srynobio commented 9 years ago

Question from @keilbeck DO you have a reference for this?

srynobio commented 9 years ago

Question from @keilbeck

I think this may need to also include chromatin. Insulators prevent interactions between promoters and enhancers in a position-dependent manner due to their ability to influence higher order chromatin structure I'm setting this to pending and will talk to you when you get back in town