TheJacksonLaboratory / diachromatic

Diachromatic is a Java application for preprocessing and quality control of Hi-C and CHi-C data.
https://diachromatic.readthedocs.io/en/latest/
GNU General Public License v3.0
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Cross-linked chromatin is digested using one or more restriction enzymes, which results in restriction fragments whose ends re-ligate thereby forming ligation junctions. #126

Closed pnrobinson closed 5 years ago

pnrobinson commented 5 years ago

This is not entirely accurate -- at least with some protocols, the ends are filled in with biotinylated nucleotides before blunt-end religation

hansenp commented 5 years ago

This is from mapping.rst in section Formation of Hi-C fragments.

I skipped this detail (and many others) in order to put the focus on concept with the three categories.