coagulation assays

[kingmanzhang]

@nicolevasilevsky @LCCarmody Are you familiar with this topic? There are a ten of assays for them.

[nicolevasilevsky]

I'll look into it.

[LCCarmody]

I know a little about platelet activation but not too much. What are the assays?

[nicolevasilevsky]

I'll list some examples below:

• [x] Loinc: 12185-5 [aPTT in Control Blood by Coagulation assay]
• [x] Loinc: 13050-0 [Protein C/Coagulation factor IX [Mass Ratio] in Platelet poor plasma]
• [ ] Loinc: 13058-3 [aPTT in Platelet poor plasma by Coagulation assay --2nd specimen]
• [ ] Loinc: 3173-2 [aPTT in Blood by Coagulation assay]
• [ ] Loinc: 13591-3 [Factor inhibitor XXX [Units/volume] in Platelet poor plasma by Coagulation assay]
• [ ] Loinc: 27815-0 [Coagulation factor XIII activity actual/normal in Platelet poor
• [ ] Loinc: 29016-3 [Argon laser coagulation treatment effects [#] Left eye] (I'm pretty sure this should be 'do not annotate')
• [ ] Loinc: 30086-3 [Coagulation factor IX inhibitor [Presence] in Platelet poor plasma by Coagulation assay]
• [ ] Loinc: 3188-0 [Coagulation factor IX activity [Units/volume] in Platelet poor plasma by Chromogenic method]
• [ ] Loinc: 3289-6 [Prothrombin activity actual/normal in Platelet poor plasma by Coagulation assay]

(these are some examples, there are more codes)

[LCCarmody]

This article seems helpful, but I will have to read closer: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417204/

[LCCarmody]

For that test, Wikipedia is helpful: "The typical reference range is between 30 seconds and 50 s (depending on laboratory). Shortening of the PTT is considered to have little clinical relevance, but some research indicates that it might increase risk of thromboembolism.[3]"

We have the term HP:0003645-prolonged partial thrombinplastin time. I don't know if we want a shortened PPT based on this.