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TobiasHeOl / kasearch

KA-Search: Rapid and exhaustive sequence identity search of known antibodies
BSD 3-Clause "New" or "Revised" License
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wifi traffic #6

Closed QUEST2179 closed 7 months ago

QUEST2179 commented 7 months ago

Dear Developer,

I downloaded oasdb_small to my computer and tried to run search locally, but noticed there is a heavy wifi traffic. Is it normal? the search is done in a remote server or in a local computer? Thanks!

TobiasHeOl commented 7 months ago

Hello! The actual search is done locally against the used pre-processed dataset (in your case oasdb_small), however; to extract the metadata for the N sequences with highest identity, the default is to extract it from the online OAS version hosted by OPIG (in order to keep the pre-processed datasets small, they do not include metadata). If you are returning a lot of sequences (large "keep_best_n"), this step might cause some heavy wifi traffic.

We understand that you might want to perform this search fully locally, so you also have the option of downloading OAS (currently ~1.3T) and extracting metadata from this local version. This allows you to run kasearch offline and most likely also speed up the meta extraction part. To use a local OAS, you need to set the argument "local_oas_path='/path/to/local/oas/'" (please see example 4 in README).

I hope this answered your question! All the best, Tobias

QUEST2179 commented 7 months ago

Very helpful, thank you so much for explanation, Tobias.