Not a bridge issue. Turned out to be an interaction between when the bridge looked for aXiom's I2C address that affected all bridges. Bridge logic changed to wait for ~10 seconds for aXiom to ACK an address, and to only check for addresses 0x66 and 0x67 rather than sweeping through all 7-bit I2C addresses.
[x] Bridge sometimes doesn't reconnect to Windows after a reset
It is not 100% known why this is happening. When the bridge gets into this state, not even a manual reset (NRESET pin) recovers the device. Adding a delay between disconnecting from the USB and performing the reset seems to improve the issue.
[x] I2C not functioning
[x] Bridge sometimes doesn't reconnect to Windows after a reset