MDMA can inhibit alcohol's intoxicating effects leading to increased drinking, which may put individuals at risk for adverse physical effects and poorer decision making. Alcohol may also reduce some of the cognitive and stimulant effects of MDMA. In addition, this combination carries an increased risk of hyperthermia and dehydration and places increased strain on the cardiovascular system. Approach this combination with caution, moderation, and sufficient hydration.
Originally posted by **zelixir25** February 26, 2024
The combination of MDMA and alcohol may increase strain on the cardiovascular system and lead to increased alcohol consumption. MDMA may also impair one's ability to recognize their level of drunkenness, leading to increased alcohol consumption and poor decision-making. Alcohol may also increase the risk of dehydration and hyperthermia (increased body temperature) when combined with MDMA.
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Hernández-López, C., Farré, M., Roset, P. N., Menoyo, E., Pizarro, N., Ortuño, J., Torrens, M., Camı́, J., & Torre, R. de la. (2002). 3,4-Methylenedioxymethamphetamine (Ecstasy) and Alcohol Interactions in Humans: Psychomotor Performance, Subjective Effects, and Pharmacokinetics. Journal of Pharmacology and Experimental Therapeutics, 300(1), 236–244. https://doi.org/10.1124/jpet.300.1.236
Ramaekers, J. G., & Kuypers, K. P. C. (2006). Acute Effects of 3,4-Methylenedioxymethamphetamine (MDMA) on Behavioral Measures of Impulsivity: Alone and in Combination with Alcohol. Neuropsychopharmacology, 31(5), 1048–1055. https://doi.org/10.1038/sj.npp.1300894
van Amsterdam, J., Brunt, T. M., Pierce, M., & van den Brink, W. (2021). Hard Boiled: Alcohol Use as a Risk Factor for MDMA-Induced Hyperthermia: a Systematic Review. Neurotoxicity Research, 39(6), 2120–2133. https://doi.org/10.1007/s12640-021-00416-z
credit to @zelixir25
thanks to immr.sun for the wording help
MDMA + Alcohol Caution
MDMA can inhibit alcohol's intoxicating effects leading to increased drinking, which may put individuals at risk for adverse physical effects and poorer decision making. Alcohol may also reduce some of the cognitive and stimulant effects of MDMA. In addition, this combination carries an increased risk of hyperthermia and dehydration and places increased strain on the cardiovascular system. Approach this combination with caution, moderation, and sufficient hydration.
Discussed in https://github.com/TripSit/drugs/discussions/76
credit to @zelixir25 thanks to immr.sun for the wording help