While this combination may be tolerated by those who are using these drugs as prescribed, recreational use of pregabalin and opioids increases risk of fatal overdose. Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Memory blackouts are likely.
Evoy, K. E., Sadrameli, S., Contreras, J., Covvey, J. R., Peckham, A. M., & Morrison, M. D. (2021). Abuse and misuse of pregabalin and gabapentin: A systematic review update. Drugs, 81(1), 125–156. https://doi.org/10.1007/s40265-020-01432-7
Lyndon, A., Audrey, S., Wells, C., Burnell, E. S., Ingle, S., Hill, R., Hickman, M., & Henderson, G. (2017). Risk to heroin users of polydrug use of pregabalin or gabapentin. Addiction, 112(9), 1580–1589. https://doi.org/10.1111/add.13843
Elliott, Simon P., et al. “Determining the Toxicological Significance of Pregabalin in Fatalities.” Journal of Forensic Sciences, vol. 62, no. 1, 2017, pp. 169–73, https://doi.org/10.1111/1556-4029.13263.
Opioids + Pregabalin
Dangerous
While this combination may be tolerated by those who are using these drugs as prescribed, recreational use of pregabalin and opioids increases risk of fatal overdose. Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Memory blackouts are likely.
Evoy, K. E., Sadrameli, S., Contreras, J., Covvey, J. R., Peckham, A. M., & Morrison, M. D. (2021). Abuse and misuse of pregabalin and gabapentin: A systematic review update. Drugs, 81(1), 125–156. https://doi.org/10.1007/s40265-020-01432-7
Lyndon, A., Audrey, S., Wells, C., Burnell, E. S., Ingle, S., Hill, R., Hickman, M., & Henderson, G. (2017). Risk to heroin users of polydrug use of pregabalin or gabapentin. Addiction, 112(9), 1580–1589. https://doi.org/10.1111/add.13843
Elliott, Simon P., et al. “Determining the Toxicological Significance of Pregabalin in Fatalities.” Journal of Forensic Sciences, vol. 62, no. 1, 2017, pp. 169–73, https://doi.org/10.1111/1556-4029.13263.
credit to @zelixir25