There is a high risk of serotonin syndrome from this combination.
Hondebrink, L., Kasteel, E. E. J., Tukker, A. M., Wijnolts, F. M. J., Verboven, A. H. A., & Westerink, R. H. S. (2017). Neuropharmacological characterization of the new psychoactive substance methoxetamine. Neuropharmacology, 123, 1–9. https://doi.org/10.1016/j.neuropharm.2017.04.035
Marti, M., Talani, G., Miliano, C., Bilel, S., Biggio, F., Bratzu, J., Diana, M., De Luca, M. A., & Fattore, L. (2021). New insights into methoxetamine mechanisms of action: Focus on serotonergic 5-HT2 receptors in pharmacological and behavioral effects in the rat. Experimental Neurology, 345, 113836. https://doi.org/10.1016/j.expneurol.2021.113836
Roth, B. L., Gibbons, S., Arunotayanun, W., Huang, X.-P., Setola, V., Treble, R., & Iversen, L. (2013). The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor. PLOS ONE, 8(3), e59334. https://doi.org/10.1371/journal.pone.0059334
DeLarge, A. F., Erwin, L. L., & Winsauer, P. J. (2017). Atypical binding at dopamine and serotonin transporters contribute to the discriminative stimulus effects of mephedrone. Neuropharmacology, 119, 62–75. https://doi.org/10.1016/j.neuropharm.2017.04.006
Kehr, J., Ichinose, F., Yoshitake, S., Goiny, M., Sievertsson, T., Nyberg, F., & Yoshitake, T. (2011). Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats: Mephedrone increases both DA and 5-HT in rat brain. British Journal of Pharmacology, 164(8), 1949–1958. https://doi.org/10.1111/j.1476-5381.2011.01499.x
4mmc + MXE Dangerous
There is a high risk of serotonin syndrome from this combination.
Hondebrink, L., Kasteel, E. E. J., Tukker, A. M., Wijnolts, F. M. J., Verboven, A. H. A., & Westerink, R. H. S. (2017). Neuropharmacological characterization of the new psychoactive substance methoxetamine. Neuropharmacology, 123, 1–9. https://doi.org/10.1016/j.neuropharm.2017.04.035 Marti, M., Talani, G., Miliano, C., Bilel, S., Biggio, F., Bratzu, J., Diana, M., De Luca, M. A., & Fattore, L. (2021). New insights into methoxetamine mechanisms of action: Focus on serotonergic 5-HT2 receptors in pharmacological and behavioral effects in the rat. Experimental Neurology, 345, 113836. https://doi.org/10.1016/j.expneurol.2021.113836 Roth, B. L., Gibbons, S., Arunotayanun, W., Huang, X.-P., Setola, V., Treble, R., & Iversen, L. (2013). The Ketamine Analogue Methoxetamine and 3- and 4-Methoxy Analogues of Phencyclidine Are High Affinity and Selective Ligands for the Glutamate NMDA Receptor. PLOS ONE, 8(3), e59334. https://doi.org/10.1371/journal.pone.0059334 DeLarge, A. F., Erwin, L. L., & Winsauer, P. J. (2017). Atypical binding at dopamine and serotonin transporters contribute to the discriminative stimulus effects of mephedrone. Neuropharmacology, 119, 62–75. https://doi.org/10.1016/j.neuropharm.2017.04.006 Kehr, J., Ichinose, F., Yoshitake, S., Goiny, M., Sievertsson, T., Nyberg, F., & Yoshitake, T. (2011). Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats: Mephedrone increases both DA and 5-HT in rat brain. British Journal of Pharmacology, 164(8), 1949–1958. https://doi.org/10.1111/j.1476-5381.2011.01499.x