There is a risk of serotonin syndrome when combining Lithium with DXM.
Lenox, R. H., & Hahn, C. G. (2000). Overview of the mechanism of action of lithium in the brain: fifty-year update. The Journal of clinical psychiatry, 61 Suppl 9, 5–15. - https://pubmed.ncbi.nlm.nih.gov/10826655/
Shahani, L. (2012). Venlafaxine Augmentation With Lithium Leading to Serotonin Syndrome. The Journal of Neuropsychiatry and Clinical Neurosciences, 24(3), E47–E47. https://doi.org/10.1176/appi.neuropsych.11080196
DeBattista, C., Sofuoglu, M., & Schatzberg, A. F. (1998). Serotonergic synergism: the risks and benefits of combining the selective serotonin reuptake inhibitors with other serotonergic drugs. Biological psychiatry, 44(5), 341–347. https://doi.org/10.1016/s0006-3223(98)00161-9
Massot, O. (1999). 5-HT1B Receptors: A Novel Target for Lithium Possible Involvement in Mood Disorders. Neuropsychopharmacology, 21(4), 530–541. https://doi.org/10.1016/S0893-133X(99)00042-1
Navarro, A., Perry, C., & Bobo, W. V. (2006). A case of serotonin syndrome precipitated by abuse of the anticough remedy dextromethorphan in a bipolar patient treated with fluoxetine and lithium. General Hospital Psychiatry, 28(1), 78–80. https://doi.org/10.1016/j.genhosppsych.2005.06.008
Henderson, M. G., & Fuller, R. W. (1992). Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Research, 594(2), 323–326. https://doi.org/10.1016/0006-8993(92)91144-4
Navarro, A., Perry, C., & Bobo, W. V. (2006). A case of serotonin syndrome precipitated by abuse of the anticough remedy dextromethorphan in a bipolar patient treated with fluoxetine and lithium. General Hospital Psychiatry, 28(1), 78–80. https://doi.org/10.1016/j.genhosppsych.2005.06.008
Lithium + DXM = Dangerous
There is a risk of serotonin syndrome when combining Lithium with DXM.
Lenox, R. H., & Hahn, C. G. (2000). Overview of the mechanism of action of lithium in the brain: fifty-year update. The Journal of clinical psychiatry, 61 Suppl 9, 5–15. - https://pubmed.ncbi.nlm.nih.gov/10826655/
Shahani, L. (2012). Venlafaxine Augmentation With Lithium Leading to Serotonin Syndrome. The Journal of Neuropsychiatry and Clinical Neurosciences, 24(3), E47–E47. https://doi.org/10.1176/appi.neuropsych.11080196
DeBattista, C., Sofuoglu, M., & Schatzberg, A. F. (1998). Serotonergic synergism: the risks and benefits of combining the selective serotonin reuptake inhibitors with other serotonergic drugs. Biological psychiatry, 44(5), 341–347. https://doi.org/10.1016/s0006-3223(98)00161-9
Massot, O. (1999). 5-HT1B Receptors: A Novel Target for Lithium Possible Involvement in Mood Disorders. Neuropsychopharmacology, 21(4), 530–541. https://doi.org/10.1016/S0893-133X(99)00042-1
Navarro, A., Perry, C., & Bobo, W. V. (2006). A case of serotonin syndrome precipitated by abuse of the anticough remedy dextromethorphan in a bipolar patient treated with fluoxetine and lithium. General Hospital Psychiatry, 28(1), 78–80. https://doi.org/10.1016/j.genhosppsych.2005.06.008
Henderson, M. G., & Fuller, R. W. (1992). Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Research, 594(2), 323–326. https://doi.org/10.1016/0006-8993(92)91144-4
Navarro, A., Perry, C., & Bobo, W. V. (2006). A case of serotonin syndrome precipitated by abuse of the anticough remedy dextromethorphan in a bipolar patient treated with fluoxetine and lithium. General Hospital Psychiatry, 28(1), 78–80. https://doi.org/10.1016/j.genhosppsych.2005.06.008