The two substances potentiate each other strongly and unpredictably, and may rapidly lead to unconsciousness. They both increase each other's side effects such as ataxia, sedation, and CNS depression. Blackouts and memory loss are significantly increased. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. Alcohol may also increase the deliriant effects of diphenhydramine. It should also be noted if the individual consuming alcohol typically has a flushing response to alcohol, diphenhydramine may reduce the reaction and mask some of the effects of the alcohol.
Dipenhydramine + Alcohol = Dangerous
The two substances potentiate each other strongly and unpredictably, and may rapidly lead to unconsciousness. They both increase each other's side effects such as ataxia, sedation, and CNS depression. Blackouts and memory loss are significantly increased. If the user falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position. Alcohol may also increase the deliriant effects of diphenhydramine. It should also be noted if the individual consuming alcohol typically has a flushing response to alcohol, diphenhydramine may reduce the reaction and mask some of the effects of the alcohol.
Diphenhydramine - an overview | ScienceDirect Topics. (n.d.). Retrieved September 4, 2024, from https://www.sciencedirect.com/topics/chemistry/diphenhydramine Ethanol - an overview | ScienceDirect Topics. (n.d.). Retrieved September 4, 2024, from https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/ethanol Miller, N. S., Goodwin, D. W., Jones, F. C., Gabrielli, W. F., Pardo, M. P., Anand, M. M., & Hall, T. B. (1988). Antihistamine blockade of alcohol-induced flushing in orientals. Journal of Studies on Alcohol, 49(1), 16–20. https://doi.org/10.15288/jsa.1988.49.16 Sicari, V., & Zabbo, C. P. (2024). Diphenhydramine. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK526010/ Weathermon, R., & Crabb, D. W. (1999). Alcohol and Medication Interactions. Alcohol Research & Health, 23(1), 40–54. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761694/
https://www.ncbi.nlm.nih.gov/books/NBK526010/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761694/ https://pubmed.ncbi.nlm.nih.gov/3347071/ https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/ethanol https://www.sciencedirect.com/topics/chemistry/diphenhydramine