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MDMA + SSRIs source addition #94

Closed utaninja closed 3 months ago

utaninja commented 5 months ago

Discussed in https://github.com/TripSit/drugs/discussions/82

Originally posted by **zelixir25** February 28, 2024 I think this is classified correctly in the current chart but it can be a bit controversial so I think it's important for us to provide a source. Sarparast, et al. (2022) is fairly recent and is a systematic review that covers all literature on the subject that was available at the time of its writing. Feduccia, et al., (2021) focuses more on efficacy of MDMA-AT but does provide the same conclusion which is that SSRIs inhibit the effects of MDMA but do not pose an increased risk of serotonin syndrome as some believe. Feduccia, A. A., Jerome, L., Mithoefer, M. C., & Holland, J. (2021). Discontinuation of medications classified as reuptake inhibitors affects treatment response of MDMA-assisted psychotherapy. Psychopharmacology, 238(2), 581–588. https://doi.org/10.1007/s00213-020-05710-w Sarparast, A., Thomas, K., Malcolm, B., & Stauffer, C. S. (2022). Drug-drug interactions between psychiatric medications and MDMA or psilocybin: a systematic review. Psychopharmacology, 239(6), 1945–1976. https://doi.org/10.1007/s00213-022-06083-y another source Malcolm, B., & Thomas, K. (2022). Serotonin toxicity of serotonergic psychedelics. Psychopharmacology, 239(6), 1881–1891. https://doi.org/10.1007/s00213-021-05876-x

These are sources suggested by @zelixir25 which I agree should be added for MDMA + SSRI's

utaninja commented 4 months ago

To clarify the issue- sources for MDMA + SSRI-

Feduccia, A. A., Jerome, L., Mithoefer, M. C., & Holland, J. (2021). Discontinuation of medications classified as reuptake inhibitors affects treatment response of MDMA-assisted psychotherapy. Psychopharmacology, 238(2), 581–588. https://doi.org/10.1007/s00213-020-05710-w

Sarparast, A., Thomas, K., Malcolm, B., & Stauffer, C. S. (2022). Drug-drug interactions between psychiatric medications and MDMA or psilocybin: a systematic review. Psychopharmacology, 239(6), 1945–1976. https://doi.org/10.1007/s00213-022-06083-y

Malcolm, B., & Thomas, K. (2022). Serotonin toxicity of serotonergic psychedelics. Psychopharmacology, 239(6), 1881–1891. https://doi.org/10.1007/s00213-021-05876-x