Originally posted by **zelixir25** March 1, 2024
Latest research shows no interaction.
Finley, P. R. (2016). Drug Interactions with Lithium: An Update. Clinical Pharmacokinetics, 55(8), 925–941. https://doi.org/10.1007/s40262-016-0370-y
Lithium + SSRIs
Safe
This interaction is used in medical settings without reported issues. If this combination is taken, caution would be recommended if any other drugs are planned to be taken on top of these that may have serotonergic activity.
Hawley CJ, Loughlin PJ, Quick SJ, Gale TM, Sivakumaran T, Hayes J, McPhee S. Efficacy, safety and tolerability of combined administration of lithium and selective serotonin reuptake inhibitors: a review of the current evidence. Hertfordshire Neuroscience Research Group. Int Clin Psychopharmacol. 2000 Jul;15(4):197-206. doi: 10.1097/00004850-200015040-00002. PMID: 10954059.
Müller-Oerlinghausen, B. Drug Interactions with Lithium. Mol Diag Ther 11, 41–48 (1999). https://doi.org/10.2165/00023210-199911010-00004
Bauer, Michael PhD, MD; Linden, Michael MD; Schaaf, Berthold; Weber, Hans J. MD. Adverse Events and Tolerability of the Combination of Fluoxetine/Lithium Compared With Fluoxetine. Journal of Clinical Psychopharmacology 16(2):p 130-134, April 1996.
Finley, P. R. (2016). Drug Interactions with Lithium: An Update. Clinical Pharmacokinetics, 55(8), 925–941. https://doi.org/10.1007/s40262-016-0370-y
Discussed in https://github.com/TripSit/drugs/discussions/85
Lithium + SSRIs Safe
This interaction is used in medical settings without reported issues. If this combination is taken, caution would be recommended if any other drugs are planned to be taken on top of these that may have serotonergic activity.
Hawley CJ, Loughlin PJ, Quick SJ, Gale TM, Sivakumaran T, Hayes J, McPhee S. Efficacy, safety and tolerability of combined administration of lithium and selective serotonin reuptake inhibitors: a review of the current evidence. Hertfordshire Neuroscience Research Group. Int Clin Psychopharmacol. 2000 Jul;15(4):197-206. doi: 10.1097/00004850-200015040-00002. PMID: 10954059. Müller-Oerlinghausen, B. Drug Interactions with Lithium. Mol Diag Ther 11, 41–48 (1999). https://doi.org/10.2165/00023210-199911010-00004 Bauer, Michael PhD, MD; Linden, Michael MD; Schaaf, Berthold; Weber, Hans J. MD. Adverse Events and Tolerability of the Combination of Fluoxetine/Lithium Compared With Fluoxetine. Journal of Clinical Psychopharmacology 16(2):p 130-134, April 1996. Finley, P. R. (2016). Drug Interactions with Lithium: An Update. Clinical Pharmacokinetics, 55(8), 925–941. https://doi.org/10.1007/s40262-016-0370-y