You can use all of the .NET Standard based libraries with Full .NET framework too. If a library supports .NETStandard 1.3, it means it's usable in .NETFramework 4.5.1+ apps and if a library supports .NETStandard 2.0, it means it's usable in .NETFramework 4.6.1+ apps. EFSecondLevelCache.Core supports both of them. A Sample to demonstrate it.
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The documentation mentions the following:
Is anything like this implemented in any of the available EF6 libraries that you know of? I'm not using .NET Core unfortunately.