WGLab / CancerVar

Clinical interpretation of somatic mutations in cancer
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Issue about the VAF and Germline Variants (CBP5 and CBP6). #11

Closed lincj1994 closed 3 years ago

lincj1994 commented 3 years ago

Hi. In your CancerVar article in bioRxiv, you stated that CancerVar contains all the above 12 evidence, among which 10 of them are automatically generated and the other two, including variant allele fraction and potential germline, require user input for manual adjustment The EVS5 and EVS6 of all variants were 0 if I didnt provide the corresponding evidence file. But if I have performed data pre-processing step to filter out possible germline variants and only kept predicted somatic mutations in the input, can the EVS5 of all variants be assigned a score of 1 or 2 and EVS6 be assigned 1 or 2 manually in the output of command-line CancerVar (in Excel)?