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WangX-Lab / DEPTH

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Work on scRNAseq #2

Open CathyXD opened 1 year ago

CathyXD commented 1 year ago

Hi, team I wondering how does this tool work on scRNAseq? Does it require pseudo-bulk? If so, what metadata is recommended to be used as pseudo group? If not, how to interpret sample heterogeneity with cell level ITH returned by DEPTH? Appreciate your response.

Regards Cathy

WangX-Lab commented 1 year ago

Thanks for the excellent question. DEPTH was originally designed for analyzing bulk data. Yes, pseudo-bulk is required if analyzing scRNA-Seq data. In analyzing scRNA-Seq data, metadata should be individual patients.

Best,

Xiaosheng

发件人: @. @.> 代表 Cathyyy0_0 发送时间: Monday, May 15, 2023 11:07 AM 收件人: WangX-Lab/DEPTH @.> 抄送: Subscribed @.> 主题: [WangX-Lab/DEPTH] Work on scRNAseq (Issue #2)

Hi, team I wondering how does this tool work on scRNAseq? Does it require pseudo-bulk? If so, what metadata is recommended to be used as pseudo group? If not, how to interpret sample heterogeneity with cell level ITH returned by DEPTH? Appreciate your response.

Regards Cathy

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